Lidocaine Hydrochloride CAS 73-78-9

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  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Lidocaine Hydrochloride Supplier & Manufacturer

Basic Info

What is Lidocaine Hydrochloride?

Lidocaine hydrochloride is an anesthetic as well as an antiarrhythmic drug. Clinically, it is mainly used for infiltration anesthetic, epidural anesthetic, topical anesthesia (consisting of mucosal anesthetic throughout thoracoscopic examination or abdominal surgical treatment) as well as nerve conduction block. It can additionally be used for early ventricular tightenings and also ventricular tachycardia after acute myocardial infarction, and also for ventricular arrhythmias triggered by digitalis poisoning, cardiac surgery as well as cardiac catheterization. But it is usually inadequate for supraventricular arrhythmias.

Lidocaine hydrochloride is an amide local anesthetic. After blood absorption or intravenous administration, it has noticeable excitatory and also inhibitory biphasic impacts on the main nerves, as well as there may be no forerunner exhilaration. When the blood drug concentration is reduced, analgesia, drowsiness, and also discomfort threshold rise; Huge, improved result or poisoning, anticonvulsant effect at subtoxic blood focus; convulsions might take place when the blood focus surpasses 5 μg · ml-1. At low doses, lidocaine hydrochloride can promote the outflow of K+ in myocardial cells, lower the self-discipline of the myocardium, and have anti-ventricular arrhythmia effects; There is no apparent result on tightening; more rise in blood medication concentration can create slowing down of cardiac transmission rate, atrioventricular block, restraint of myocardial contractility as well as decline of heart result.

Lidocaine Hydrochloride Uses

Lidocaine hydrochloride has the characteristics of strong penetrability, solid dispersibility, and also quick onset of action. Its anesthetic effectiveness is twice that of procaine, as well as its toxicity is 1. The anesthesia impact can appear within 5 minutes after administration, and also the anesthesia effect can last for 1 to 1.5 hours, which is 50% longer than that of procaine. After absorption, it can prevent the main nervous system, hinder ventricular self-control, shorten the refractory period, and can be utilized to regulate ventricular tachycardia as well as treat arrhythmia symptoms such as ventricular early beats, ventricular tachycardia and also ventricular fibrillation. It is effective for arrhythmia caused by cardiovascular disease or cardiac glycosides, however ineffective for supraventricular tachycardia. This item acts quickly, lasts momentarily, is ineffective when taken by mouth, as well as is usually administered as an intravenous shot.

Lidocaine hydrochloride is a local anesthetic as well as an antiarrhythmic medication. Mostly utilized for infiltration anesthesia, epidural anesthetic, topical anesthesia (including mucosal anesthetic throughout thoracoscopy or stomach surgical procedure) as well as nerve transmission block.

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Indications of Lidocaine Hydrochloride

Lidocaine hydrochloride is a medium-acting amide anesthetic. For local anesthetics and antiarrhythmic drugs. Primarily used:

  • Seepage anesthetic, epidural anesthesia, topical anesthetic (including mucosal anesthetic during thoracoscopy or abdominal surgical procedure) and also nerve transmission block.
  • Treat early ventricular contractions as well as ventricular tachycardias after acute myocardial infarction (AMI), as well as ventricular arrhythmias caused by digitalis poisoning, heart surgery, as well as cardiac catheterization, however it is normally inadequate for supraventricular arrhythmias.

Medicine Interactions

  1. Integrated with cimetidine as well as β-receptor blockers such as propranolol, metoprolol, as well as nadolol, the metabolic process of lidocaine with the liver is hindered, as well as the blood concentration of lidocaine boosts, which can create Heart and also nerve system negative responses happened. The dosage of lidocaine should be changed, as well as the electrocardiogram needs to be monitored and the plasma focus of lidocaine need to be checked.
  2. Barbiturates can promote the metabolism of lidocaine, as well as the combination of the two drugs can trigger bradycardia as well as sinus apprehension.
  3. Incorporated with procainamide, it can produce short-term ecstasy and also hallucinations, however it does not impact the plasma concentration of lidocaine hydrochloride.
  4. Isoproterenol boosts the hepatic blood flow, which can enhance the complete clearance price of lidocaine hydrochloride; norepinephrine minimizes the hepatic blood flow, which can decrease the complete clearance price of lidocaine hydrochloride.
  5. Compatibility with the following drugs: phenobarbital, thiopental sodium, nitroprusside, mannitol, amphotericin B, ampicillin, mesobital, sulfadiazine salt.


  • Lidocaine hydrochloride – PubChem
  • Wu Zhonghua; Zhang Xiaopeng; Chen Guicai; Xu Tianhua; He Qilei; Wen Ming. A preparation method of lidocaine hydrochloride. CN201510738390.7

Lidocaine Hydrochloride Supplier and Manufacturer

As a lidocaine hydrochloride supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best lidocaine hydrochloride raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for lidocaine hydrochloride and related products, please contact our service staff Zhishang Chemical directly, and we will provide you with high-quality products at the best price.

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