Lidocaine HCl CAS 6108-05-0 Linocaine Hydrochloride
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Lidocaine HCl Suppiler&Manufacturer
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Lidocaine HCl: The Complete Guide
Lidocaine HCl for Sale
Basic Info of Lidocaine HCl
Basic Info
Chemical Properties
Other Info
Basic Info
Chemical Name: | Lidocaine HCl |
Other Name: | Linocaine hydrochloride; Lidocaine HCl powder |
CAS: | 6108-05-0 |
EINECS: | 612-079-4 |
Type: | Pharmaceutical raw materials |
Molecular Formula: | C14H25ClN2O2 |
Molecular Weight: | 288.81 |
Chemical Properties
Melting point | 75-79℃ |
storage temp. | 2-8°C |
solubility | H2O: soluble |
form | solid |
color | white |
Water Solubility | Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether. |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Lidocaine HCl MSDS; Lidocaine HCl COA |
What is Lidocaine HCl?
The chemical name of lidocaine hydrochloride is N-(2,6-xylyl)-2-(diethylamino)acetamide hydrochloride-hydrate, which is a common amide local anesthetic. The patch can be used as a topical anesthetic, has analgesic effect, can be absorbed through the skin or mucous membranes, and is clinically used for local infiltration anesthesia before superficial surgery on the skin or mucous membranes; it can also relieve post-herpetic neuralgia, like other local anesthetics , Topical application has a certain antipruritic effect, and also has an antiarrhythmic effect.
Lidocaine hydrochloride is an intermediate-acting amide local anesthetic. For local anesthetics and also antiarrhythmic drugs. Generally made use of for:
- Infiltration anesthetic, epidural anesthesia, topical anesthesia (including mucosal anesthetic during thoracoscopy or stomach surgical treatment) and nerve transmission block.
- Treat ventricular early beats as well as ventricular tachycardia after acute myocardial infarction (AMI), and ventricular arrhythmia brought on by digitalis poisoning, heart surgical treatment, and also cardiac catheterization, however it is normally ineffective for supraventricular arrhythmias.
Lidocaine HCl Uses
Linocaine hydrochloride is a fast voltage gated sodium channel blocker.
Lidocaine hydrochloride is an amide type local anesthetic. After blood absorption or intravenous administration, the drug has evident biphasic effects of excitation and restraint on the main nervous system, and also there can be no forerunner excitation. When the blood focus is low, analgesia, sleepiness, and the discomfort limit are raised; With the boost of the dose, the effect or toxicity increases, and also the sub poisonous blood focus has an anticonvulsant result.
Lidocaine hydrochloride has the characteristics of strong penetrability, solid diffusion and also fast beginning. Its anesthetic efficiency is two times that of procaine, while its toxicity is 1. Anesthetic can occur 5 mins after management, as well as the anesthetic impact lasts for 1 to 1.5 hours, 50% longer than that of procaine. After absorption, it can inhibit the main nerve system, prevent the ventricular automaticity, shorten the refractory period, and can be made use of to regulate ventricular tachycardia as well as treat ventricular early beats, ventricular tachycardia, ventricular fibrillation and also various other arrhythmic symptoms. It is effective for heart disease or arrhythmia triggered by heart glycosides, but not for supraventricular tachycardia. This product has quickly action, brief period and also is inefficient after oral management. It is commonly made use of as an intravenous shot.
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Preparation of Lidocaine HCl
Report one
Report two
Report one
Preparation of intermediate 2,6-dimethylaniline
24.43 g (0.2 mol) of 2,6-xylenol, 63.1 g (0.6 mol) of ammonia water, 1.06 g of 5% Pd/C, and 2.52 g (0.02 g of 2,6-dimethylcyclohexanone) were successively added to the reaction vessel. mol), reacted at 185 °C for 6 h, cooled to room temperature, filtered, recovered Pd/C and applied; the filtrate was distilled under reduced pressure, recovered 2,6-dimethylcyclohexanone and applied next time, the residue was washed with water once, and left to stand for stratification. , the oil layer is the intermediate 2,6-dimethylaniline 23.35g, the HPLC purity is 98.32%, and the yield is 94.73%.Preparation of lidocaine hydrochloride
To the there-necked flask with the distillation device, add 15.12g (0.28mol) of sodium methoxide, 24.24g (0.2mol) of the intermediate 2,6-dimethylaniline and 31.9g (0.22g) of N,N-diethylaminoacetate methyl ester successively. mol), heated to 95°C, and the methanol generated by the reaction was distilled off while reacting, until no methanol was evaporated, continued the reaction for 30 min, cooled to room temperature, added dichloroethane to dissolve, washed twice with water, and allowed to stand for stratification. The organic layer is the dichloroethane solution of lidocaine base.In the dichloroethane solution of above-mentioned lidocaine base, add hydrochloric acid 2.56g, then adjust the pH to 3.5 with hydrogen chloride, add activated carbon to reflux for 20min, filter, concentrate the filtrate, crystallize by cooling, dry to obtain lidocaine hydrochloride 48.28g, HPLC purity was 99.52%, the yield was 88.72%, and the total yield was 84.04%.
Report two
- Add acetone 200L, 2,6-dimethylaniline 50.0kg (412.6mol), potassium carbonate 142.6kg (1031.5mol) to the 500L enamel reaction kettle, stir and adjust the temperature of the material to 20±5°C, keep at Within this temperature range, 48.9 kg (433.2 mol) of chloroacetyl chloride was added dropwise at a high position, and the reaction was stirred at this temperature for 0.5 h after the dropping. Add 33.2kg (453.9mol) of diethylamine, heat to 60±5°C for 8h, filter, add hydrochloric acid to the filtrate with stirring, and adjust the pH of the filtrate to below 4.
- Concentrate the above reaction solution under reduced pressure at 50±5°C until no liquid is evaporated, add 200L acetone, heat and dissolve completely, add 2kg activated carbon, stir and decolorize at 55～65°C for 0.5h, press filter to clean area Crystallization kettle, stirring and cooling for crystallization, cooling to below -5°C for 3h, shaking off for filtration, and vacuum drying at 40-50°C in double cones for 4h to obtain 93.4kg of white crystalline powder, yield: 78.38%, HPLC normalized purity: 99.84 %.
Others
Medicine Interactions
Precautions
Medicine Interactions
- Cimetidine as well as β-blockers can prevent the metabolic process of lidocaine in the liver and enhance the blood focus, which can cause adverse reactions of the heart as well as nervous system. The dose of lidocaine hydrochloride need to be adjusted.
- Barbiturates can advertise the metabolism of lidocaine hydrochloride, and also the combination of the two medications can cause bradycardia and sinus apprehension.
- Combination with procainamide can create transient ecstasy and also hallucinations, but does not influence the plasma concentration of this item.
- Isoproterenol increases hepatic blood circulation, which can increase the total clearance price of this product; norepinephrine reduces hepatic blood flow, which can reduce the total clearance price of lidocaine hydrochloride.
- Conflict with the adhering to drugs: phenobarbital, thiopental sodium, sodium nitroprusside, mannitol, amphotericin B, ampicillin, sulfadiazine.
Precautions
- Those who are allergic to other local anesthetics may also be allergic to lidocaine hydrochloride.
- Use with caution in the following situations: pregnancy, neonates, especially premature infants, patients with reduced hepatic blood flow, liver and kidney insufficiency, congestive heart failure, severe myocardial damage, hypovolemia and shock.
- Strictly control the concentration and the total amount of medication, overdose can cause convulsions and cardiac arrest; its metabolism in the body is slower than that of procaine, and it has an accumulation effect, which can cause poisoning and convulsions.
- The dose for the elderly should be adjusted according to the needs and tolerance, and the dose should be halved for those over 70 years old.
- Prevent accidental entry into blood vessels during anesthesia and prevent local anesthetic poisoning.
- When treating arrhythmia, attention should be paid to monitoring blood pressure, electrocardiogram, and rescue equipment; if the P-R interval of electrocardiogram is prolonged or the QRS wave is widened, and other arrhythmias occur or the original arrhythmia is aggravated, the drug should be discontinued immediately.
- During anesthesia, the P-R interval of the electrocardiogram is prolonged or the QRS wave is widened, and the drug should be discontinued immediately if other arrhythmias occur or the original arrhythmia is aggravated.
Reference
- Lidocaine hydrochloride monohydrate – PubChem
- [Chinese invention, Chinese invention authorization] CN201510738390.7 A preparation method of lidocaine hydrochloride
Lidocaine HCl Suppliers and Manufacturers
As a lidocaine hcl supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best lidocaine hcl raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have demand for lidocaine hcl and related products, please contact our service staff Zhishang Chemical – White directly, we will provide you with high-quality products at the best price.
Quality Control of Lidocaine HCl
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