Levomefolate Calcium CAS 151533-22-1
Factory Supply Levomefolate Calcium CAS 151533-22-1 with Best Price
- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Levomefolate Calcium Supplement
Levomefolate Calcium: The Complete Guide
Index of Levomefolate Calcium Contents
Levomefolate Calcium for Sale
Basic Info of Levomefolate Calcium
Calcium L-5-Methyltetrahydrofolate; L-5-Methyltetrahydrofolate calcium; levomefolate; Levomefolic acid; L-5-methyltetrahydrofolate calcium salt
Pharmaceutical intermediates; Pharmaceutical raw materials
What is Levomefolate Calcium?
Calcium levofolate is an organic calcium salt of (6S) -5-methyltetrahydrofolate. It has the effect of antidepressants. It contains (6S) -5-methyltetrahydrofolate (2-).
L-folic acid (inn, also called l-5-mthf, l-methylfolic acid as well as l-5-methyltetrahydrofolate as well as (6 s) -5-methyltetrahydrofolate and (6 s) -5-mthf) is the main bioactive type of folic acid, which is utilized at the mobile level for DNA reproduction, cysteine cycle and also homocysteine policy. It is likewise discovered in circulation and also is delivered to tissues via membrane layers and throughout the blood-brain barrier.
In the cells, l-methylfolate is made use of for homocysteine methylation to create methionine and tetrahydrofolate (THF). THF is a straight receptor for a carbon device and also is made use of to manufacture thymidine DNA, purine (RNA and also DNA) as well as methionine. Unmethylated kind of folic acid (vitamin B 9) is an artificial kind of folic acid, which must be lowered by dihydrofolate reductase (DHFR) to have biological task. It is manufactured from polyglutamylated dietary folic acid in the absorbing cells of the small intestine. It is a methylated by-product of tetrahydrofolate.
Levomefolate Calcium Uses
- Absence of folic acid minimizes the capability of cells to synthesize as well as repair DNA, and also folic acid supplementation might be a much more beneficial approach.
- Biochemical paths for bioactivity of folic acid entail a collection of chemical reactions as well as cofactors. Taken in folic acid is lowered and also methylated to 5-MTHF during intestinal tract mucosal cell metabolic process. This conversion is limited and also does not alter the visibility of folic acid in the blood circulation, tyrosine is consequently transformed to s-adenosylmethionine (SAMe), a methyl contributor associated with a variety of biochemical procedures.
- Levomefolate calcium can additionally be made use of as a benefactor to participate in the synthesis of nucleotides to sustain the biosynthesis of DNA.
- Deficiency of folic acid is typically as a result of insufficient absorption due to vitamin shortage. While pregnant and also breastfeeding, the requirement for folic acid is raised throughout the development of kids. Under the influence of absorption or metabolic rate, or under the influence of drugs, intake of folic acid-rich foods can not assure the offered dosage, so it requires to be offered.
- Levomefolate calcium belongs to folic acid vitamins (vitamin B9, fol AcIn). It is a coenzyme type of folic acid and also a much more bioavailability substitute in nutritional supplements.
- Levomefolate calcium is involved in many essential processes in vivo, consisting of DNA replication, cysteine cycle and also homocysteine guideline. It is also discovered in the flow as well as crosses the membrane layer right into the tissue and throughout the blood-brain barrier. It can be used to deal with extreme depression, heart disease and also cancer cells. It can be utilized to deal with typical hyperhomocysteinemia in hemodialysis individuals.
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Application of Levomefolate Calcium
Levomefolate calcium is primarily an antidote to folic acid antagonists (such as methotrexate, pyrimidine, benzylcephalexin and methoxybenzyl) and is generally utilized to stop severe poisonous as well as negative effects brought on by excessive or too much methotrexate.
- Folic acid is made use of to treat the following conditions, such as inflammatory looseness of the bowels as well as healthy protein energy poor nutrition (lack of nutrition), megaloblastic anemia caused by pregnancy or early stage.
- As an adjuvant treatment for colon as well as anal cancer.
- Combined with 5-FU to treat digestive system tumors or various other 5-FU delicate growths. High dosage CF is utilized in combination with 5-FU (LF). Presently, the standard scheme is to treat colon and also rectal cancer.
- For youth leukemia, lymphoma and osteosarcoma, if saved, high-dose methotrexate should be made use of.
Clinical Use of Levomefolate Calcium
Folic acid is a kind of water-soluble compound, belonging to vitamin B complex, which is essential for many metabolic functions, including the process of CNS development and metabolism and DNA and RNA production, mainly in infancy, adolescence and pregnancy.
Calcium levoflonate is an active metabolic form of folic acid in the body.
The consequences of folic acid deficiency can be as severe as birth defects (“spina bifida”), megaloblastic anemia, and certain types of depression.
Calcium levofolate may be the most effective treatment for these defects.
Calcium levofolate is developed in numerous clinical supplements for folic acid deficiency or boosted intake; It is suggested while pregnant to avoid birth defects connected with CNS formation as well as feature.
It is likewise an active ingredient in pharmaceutical products prescribed for certain types of clinical depression, behavior conditions as well as mild cognitive problems (MCI).
- “5-methyltetrahydrofolate – Compound Summary”, PubChem, NCBI
- “CerefolinNAC Caplets Package Insert” (PDF).
- Sussman, Norman (1 March 2009). “Selecting a First-line Antidepressant: New Analysis”. Primary Psychiatry. 16: 19–22.