Levomefolate Calcium CAS 151533-22-1
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Factory Supply Levomefolate Calcium CAS 151533-22-1 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Levomefolate Calcium Supplier & Manufacturer
Levomefolate Calcium: The Complete Guide
- Item 1: Basic Info of Levomefolate Calcium
- Item 2: What is Levomefolate Calcium?
- Item 3: Levomefolate Calcium Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Levomefolate Calcium
- Item 6: Clinical Use of Levomefolate Calcium
- Item 7: Quality Control of Levomefolate Calcium
- Item 8: Hot Sale Products
- Item 9: Get Levomefolate Calcium Quotation
Levomefolate Calcium for Sale
Basic Info of Levomefolate Calcium
Basic Info
Chemical Properties
Other Info
Basic Info
Chemical Name: | Levomefolate Calcium |
Other Name: | Calcium L-5-Methyltetrahydrofolate; L-5-Methyltetrahydrofolate calcium; levomefolate; Levomefolic acid; L-5-methyltetrahydrofolate calcium salt |
CAS: | 151533-22-1 |
EINECS: | 691-636-3 |
Type: | Pharmaceutical intermediates; Pharmaceutical raw materials |
Molecular Formula: | C20H27CaN7O6 |
Molecular Weight: | 501.56 |
Chemical Properties
Melting point | >300°C |
storage temp. | Inert atmosphere,2-8°C |
CAS | 151533-22-1 |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Levomefolate Calcium MSDS; Levomefolate Calcium COA |
What is Levomefolate Calcium?
Calcium levofolate is an organic calcium salt of (6S) -5-methyltetrahydrofolate. It has the effect of antidepressants. It contains (6S) -5-methyltetrahydrofolate (2-).
L-folic acid (inn, also called l-5-mthf, l-methylfolic acid as well as l-5-methyltetrahydrofolate as well as (6 s) -5-methyltetrahydrofolate and (6 s) -5-mthf) is the main bioactive type of folic acid, which is utilized at the mobile level for DNA reproduction, cysteine cycle and also homocysteine policy. It is likewise discovered in circulation and also is delivered to tissues via membrane layers and throughout the blood-brain barrier.
In the cells, l-methylfolate is made use of for homocysteine methylation to create methionine and tetrahydrofolate (THF). THF is a straight receptor for a carbon device and also is made use of to manufacture thymidine DNA, purine (RNA and also DNA) as well as methionine. Unmethylated kind of folic acid (vitamin B 9) is an artificial kind of folic acid, which must be lowered by dihydrofolate reductase (DHFR) to have biological task. It is manufactured from polyglutamylated dietary folic acid in the absorbing cells of the small intestine. It is a methylated by-product of tetrahydrofolate.
Levomefolate Calcium Uses
- Absence of folic acid minimizes the capability of cells to synthesize as well as repair DNA, and also folic acid supplementation might be a much more beneficial approach.
- Biochemical paths for bioactivity of folic acid entail a collection of chemical reactions as well as cofactors. Taken in folic acid is lowered and also methylated to 5-MTHF during intestinal tract mucosal cell metabolic process. This conversion is limited and also does not alter the visibility of folic acid in the blood circulation, tyrosine is consequently transformed to s-adenosylmethionine (SAMe), a methyl contributor associated with a variety of biochemical procedures.
- Levomefolate calcium can additionally be made use of as a benefactor to participate in the synthesis of nucleotides to sustain the biosynthesis of DNA.
- Deficiency of folic acid is typically as a result of insufficient absorption due to vitamin shortage. While pregnant and also breastfeeding, the requirement for folic acid is raised throughout the development of kids. Under the influence of absorption or metabolic rate, or under the influence of drugs, intake of folic acid-rich foods can not assure the offered dosage, so it requires to be offered.
- Levomefolate calcium belongs to folic acid vitamins (vitamin B9, fol AcIn). It is a coenzyme type of folic acid and also a much more bioavailability substitute in nutritional supplements.
- Levomefolate calcium is involved in many essential processes in vivo, consisting of DNA replication, cysteine cycle and also homocysteine guideline. It is also discovered in the flow as well as crosses the membrane layer right into the tissue and throughout the blood-brain barrier. It can be used to deal with extreme depression, heart disease and also cancer cells. It can be utilized to deal with typical hyperhomocysteinemia in hemodialysis individuals.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
Contact Us
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- Phone: +86 176 5311 3209
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If you want to buy levomefolate calcium, pls contact us to get a free quote.
Application of Levomefolate Calcium
Levomefolate calcium is primarily an antidote to folic acid antagonists (such as methotrexate, pyrimidine, benzylcephalexin and methoxybenzyl) and is generally utilized to stop severe poisonous as well as negative effects brought on by excessive or too much methotrexate.
- Folic acid is made use of to treat the following conditions, such as inflammatory looseness of the bowels as well as healthy protein energy poor nutrition (lack of nutrition), megaloblastic anemia caused by pregnancy or early stage.
- As an adjuvant treatment for colon as well as anal cancer.
- Combined with 5-FU to treat digestive system tumors or various other 5-FU delicate growths. High dosage CF is utilized in combination with 5-FU (LF). Presently, the standard scheme is to treat colon and also rectal cancer.
- For youth leukemia, lymphoma and osteosarcoma, if saved, high-dose methotrexate should be made use of.
Clinical Use of Levomefolate Calcium
Folic acid is a kind of water-soluble compound, belonging to vitamin B complex, which is essential for many metabolic functions, including the process of CNS development and metabolism and DNA and RNA production, mainly in infancy, adolescence and pregnancy.
Calcium levoflonate is an active metabolic form of folic acid in the body.
The consequences of folic acid deficiency can be as severe as birth defects (“spina bifida”), megaloblastic anemia, and certain types of depression.
Calcium levofolate may be the most effective treatment for these defects.
Calcium levofolate is developed in numerous clinical supplements for folic acid deficiency or boosted intake; It is suggested while pregnant to avoid birth defects connected with CNS formation as well as feature.
It is likewise an active ingredient in pharmaceutical products prescribed for certain types of clinical depression, behavior conditions as well as mild cognitive problems (MCI).
Reference
- “5-methyltetrahydrofolate – Compound Summary”, PubChem, NCBI
- “CerefolinNAC Caplets Package Insert” (PDF).
- Sussman, Norman (1 March 2009). “Selecting a First-line Antidepressant: New Analysis”. Primary Psychiatry. 16: 19–22.
Levomefolate Calcium Supplier and Manufacturer
As a levomefolate calcium supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best levomefolate calcium raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for levomefolate calcium and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Service
FAQ
Shipping
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Levomefolate Calcium
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