Levodopa CAS 59-92-7 L-dopa
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Factory Supply Levodopa CAS 59-92-7 L-dopa with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Levodopa Supplier & Manufacturer
Levodopa: The Complete Guide
- Item 1: Basic Info
- Item 2: What is Levodopa?
- Item 3: Levodopa Uses
- Item 4: The Manager has Something to Say
- Item 5: The Past and Present of Levodopa
- Item 6: Precautions for levodopa in the treatment of Parkinson's disease
- Item 7: Quality Control of Levodopa
- Item 8: Hot Sale Products
- Item 9: Get Levodopa Quotation
Levodopa for Sale
Basic Info
Basic Info
| Chemical Name: | Levodopa |
| Other Name: | L-dopa; 2-Amino-3-(3,4-dihydroxyphenyl)propanoicacid |
| CAS: | 59-92-7 |
| EINECS: | 200-445-2 |
| Type: | Plant extracts; Pharmaceuticals, pesticides, dye intermediates; Pharmaceutical raw materials |
| Molecular Formula: | C9H11NO4 |
| Molecular Weight: | 197.19 |
Chemical Properties
Melting point | 276-278 °C (lit.) |
alpha | -11.7 º (c=5.3, 1N HCl) |
Boiling point | 334.28°C (rough estimate) |
density | 1.3075 (rough estimate) |
refractive index | -12 ° (C=5, 1mol/L HCl) |
storage temp. | 2-8°C |
solubility | Slightly soluble in water, practically insoluble in ethanol (96 per cent). It is freely soluble in 1 M hydrochloric acid and sparingly soluble in 0.1 M hydrochloric acid . |
form | Crystalline Powder |
pka | 2.32(at 25℃) |
color | White to creamy |
Water Solubility | Slightly soluble in water, dilute hydrochloric acid and formic acid. Insoluble in ethanol. |
Stability: | Stable. Incompatible with strong oxidizing agents. Light and air sensitive. |
Other Info
| Brand Name: | Zhishang Chemical |
| Provide: | Levodopa MSDS; Levodopa COA |
What is Levodopa?
Levodopa is the precursor of dopamine, as well as it is a typically made use of medication name worldwide. Different manufacturers have various trade names when the drugs get on the market. Dental levodopa tablets normally degenerate and liquify in the belly, then release into the duodenum, after that reach the small intestine, and absorb right into the blood at the top end of the small intestine. A tiny part of levodopa can lastly go through the “blood-brain obstacle” and go into the mind.
The essence of Parkinson’s disease is the death of dopamine-secreting neurons in the midbrain of the patient, resulting in a lack of dopamine in the brain, causing patients to experience a series of symptoms such as tremor, stiffness, and slow movement. Dopamine is a neurotransmitter that acts as a trigger for the brain to direct the rest of the body to move. However, it is ineffective to take dopamine directly or inject dopamine into the patient, because dopamine cannot enter the brain tissue through the blood-brain barrier blood vessels. In addition, many peripheral tissues and organs have dopamine receptors. If dopamine is directly administered orally or intramuscularly, it will cause side effects that many patients cannot tolerate.
Levodopa Uses
Levodopa can deal with Parkinson’s illness and also Parkinson’s syndrome; Deal with liver coma, enhance main feature, make the individual awake, and also improve signs. Advertise sleep as well as minimize fat; Increase bone thickness and also reverse weakening of bones; Rise muscle strength as well as sexual capability.
- Levodopa is the direct precursor of dopamine as well as the product of tyrosine hydroxylase. It originates from vanillin and also is extensively made use of in the therapy of Parkinson’s disease. It is most generally utilized in mix with outer decarboxylase inhibitors such as benzylhydrazine and carbidopa.
- 3,4-Dihydroxy-L-phenylalanine or L-DOPA is an all-natural isomer of the direct precursor of dopamine that crosses the blood-brain barrier. It is used to deal with Parkinson’s illness as well as is the product of tyrosine hydroxylase.
- Levodopa is one of the reliable medicines for the therapy of shake paralysis currently. It is among the forerunners for the synthesis of norepinephrine and also dopamine in the body and also belongs to catecholamine. Levodopa can enter the brain with the blood-brain obstacle, as well as play a role by decarboxylation of Doma decarboxylase into dopamine.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
Contact Us
- Email: sales002@sdzschem.com
- Phone: +86 176 5311 3209
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The Past and Present of Levodopa
1913
Swiss biochemist Marcus Guggenheim isolated levodopa from Windsor beans. In order to explore its effectiveness, he tried 2.5 g himself, which caused severe nausea and vomiting.
1957
Arvid Carlsson discovered that dopamine is an important neurotransmitter in the brain, and at the same time, reserpine can reduce the concentration of dopamine, resulting in Parkinson-like symptoms, and found that Parkinson’s syndrome is mainly caused by the lack of dopamine. In addition, levodopa has also been found to be useful in the treatment of Parkinson’s disease. Therefore, in 2000, he was awarded the Nobel Prize in Physiology or Medicine.
1961
Birkmayer and Hornykiewicz conducted the first clinical trials of levodopa. They gave patients with Parkinson’s disease intravenous levodopa, and the patients’ symptoms improved miraculously. Since then, doctors throughout Europe and the United States have been testing the efficacy of levodopa. However, perhaps due to insufficient dosage, the number of effective patients was limited, which once caused the academic community to give up the research on levodopa treatment of Parkinson’s disease.
1968
Cotzias et al. reported that patients with Parkinson’s disease after oral administration of levodopa had significantly improved symptoms of dyskinesia, and the effect was remarkable. The era of levodopa is officially announced. At the same time, levodopa was approved by the US Food and Drug Administration (FDA) and officially used in clinical practice.
1960s
And levodopa was finally able to be commercially produced thanks to American chemist William Knowles. He produced a catalyst that, when added to the catalyst, produced almost 100 percent pure levodopa. Asymmetric hydrogenation reaction has been widely used in the industrial synthesis of pharmaceutical industry, including antibiotics, anti-infective drugs and heart disease drugs. For this reason, William Knowles won the Nobel Prize in Chemistry in 2001.
1973
The compound preparation of benserazide, carbidopa and levodopa is approved by FDA. Concomitant administration of levodopa with a dopa decarboxylase inhibitor may improve bioavailability and tolerability by reducing peripheral metabolism of levodopa. This is also the type of preparation that most Parkinson’s patients are currently taking, including Madopar (Dopaserazide Tablets), Xining (Carbidopa Sustained Release Tablets) and Xilaimei (Carbidopa Levodopa Tablets) ). Since then, it has been the prelude to the gold standard of anti-Parkinson treatment for decades.
1989-2010
Dopamine receptor agonists, monoamine oxidase inhibitors, catechol-O-methyltransferase inhibitors, etc. have come out one after another, and combined with levodopa can further improve the bioavailability of levodopa and reduce motor complications (symptom fluctuations and dyskinesias) occur.
Precautions for levodopa in the treatment of Parkinson's disease
Medications should be taken on time and in doses as directed by your doctor. Because it is necessary to maintain a relatively stable blood concentration to control the occurrence of the disease well, the time and dose of medication should not be changed arbitrarily to avoid missed doses.
A small number of patients will show some serious adverse reactions in the early stage of medication. At this time, the dosage should not be increased, and the dosage should be reduced, but complete withdrawal of the drug should be avoided, so that the patients themselves can go through a certain process of adaptation to the drug. When the adverse reactions disappear or can be tolerated, the daily dose can be slowly increased gradually.
- Blood and Lymphatic System
Including hemolytic anemia, transient leukopenia and thrombocytopenia, blood cells, liver and kidney function should be checked regularly. - Digestive system
Some patients have nausea, vomiting, slow digestion, anorexia and so on. - Nervous system
Individual patients experience loss of taste or disturbance, and can cause drowsiness and so on. - Vascular system
Orthostatic hypotension is common in patients, and the dosage should be appropriately reduced. - Skin and subcutaneous tissue
Occasional allergic symptoms such as itching and rash.
For patients with drug allergies, it should not be used
It should be prohibited for patients with liver and kidney insufficiency, heart disease, angle-closure glaucoma, and mental illness.
For women who are pregnant or breastfeeding, it should be prohibited to use.
It should be contraindicated in patients with incomplete skeletal development.
Under normal circumstances, patients should take the medicine before meals to reduce the influence of food on drug absorption.
If patients need to take iron medicines, they should take iron medicines 2 hours after taking levodopa medicines, because iron medicines will affect the absorption of levodopa medicines.
Avoid high-fat, high-protein diets, which can reduce the effectiveness of levodopa drugs.
Levodopa should not be used simultaneously with sympathomimetic drugs (epinephrine, norepinephrine, isoproterenol, or amphetamine, etc.), because levodopa can enhance the effects of these drugs.
It cannot be taken together with neuroleptics, opioids and antihypertensive drugs containing reserpine, because the above drugs will inhibit the therapeutic effect of levodopa drugs.
Reference
- Levodopa – PubChem
- Levodopa: Uses, Interactions, Mechanism of Action – DrugBank
Levodopa Supplier and Manufacturer
As a levodopa supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best levodopa raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for levodopa and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Levodopa
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