L-Methionine CAS 63-68-3
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- Appearance: White powder
- Assay: 99. 0%min
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L-Methionine: The Complete Guide
L-Methionine for Sale
Basic Info of L-Methionine
Food additives; Pharmaceutical raw materials; Organic raw materials; Agricultural raw materials; Plant extracts; Daily chemicals; Pharmaceuticals, pesticides, dye intermediates
What is L-Methionine?
The molecular formula of methionine is C5H11NO2S, and also the molecular weight is 149.21. The taxonomic name is methylthiobutanine. It is normally L-form and is a component of healthy protein. White flake crystal or crystalline powder. The melting point of L-body is 280 ～ 281 ℃ (disintegration), soluble in water, insoluble in absolute ethanol, ether, benzene, petroleum ether and also acetone. The melting point of the racemate is 281 ° C (decay), soluble in weaken services of water, acid as well as antacids, quickly soluble in 95% ethanol, insoluble in ether.
Both L-type and also D-type methionine have the same organic activity. In healthy protein synthesis, methionine is the first step in the “translation” of message RNA right into healthy protein. Without the visibility of methionine, protein biosynthesis can not start. It appropriates for the prevention as well as treatment of liver disease and arsenic poisoning, and is also made use of as an artificial additive. Methionine is widely used in the fields of medicine, food, feed as well as cosmetics, amongst which the amount of feed additives is the biggest. As the first limiting necessary amino acid for chicken, methionine is an essential additive in pet feed. Pet feed with methionine can help pets grow rapidly in a short time, boost lean meat and also reduce the feeding cycle, saving concerning 40 % feed. In the pharmaceutical industry, methionine is one of the major parts of amino acid mixture and also compound amino acids.
Along with taking part in the transfer of methyl groups in animals, the metabolic process of phosphorus as well as the synthesis of epinephrine, choline as well as creatine, methionine is additionally the raw material for the synthesis of protein and also cystine. With the continual rise of the worldwide population as well as living criteria, the need for methionine in the international market has actually preserved a quick growth trend for a long time. Today, there are four major varieties of methionine marketed in the market, particularly strong methionine, fluid hydroxymethionine, and also fluid methionine. Sodium salt and strong hydroxymethionine calcium salt. In the last few years, the global demand for methionine has expanded at a yearly price of 4% to 5%. In 2010, the annual production capacity of global methionine surpassed 1 million bunches, as well as the output had to do with 900,000 bunches.
- Non-specific resistance
Research studies have actually reported that critical methionine deficiency can minimize the phagocytosis of outer lymphocytes in griddles. The examination revealed that the lotion globulin web content of griddles increased linearly with the boost of nutritional liquid methionine hydroxyl analog (LMA) level, and also peripheral lymphocytes enhanced linearly. The phagocytic task and also product lysozyme activity boosted initially and afterwards decreased with the boost of LMA supplements degree, suggesting that LMA supplementation in the diet regimen can improve the feed utilization rate as well as non-specific immune feature of griddles.
- Specific resistance
Humoral resistance Many research studies have actually revealed that dietary methionine levels can affect the humoral immunity of animals. When feeding 0-21-day-old broilers with 6 different degrees of methionine in a diet plan containing 21% crude healthy protein, it was located that when the level of methionine was 0.60%, the titer of sheep erythrocyte antibody increased, but when the degree of methionine was 0.60% 0.70% does not influence the product antibody titer after inoculation. Appropriate enhancement of methionine in the diet regimen of mobile immune chicken can advertise the spreading and change ability of T lymphocytes in outer blood, thymus as well as spleen, while the lack of methionine decreases the proliferation and also change ability of T lymphocytes.
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Application of L-Methionine
Methionine is an essential amino acid and has important nutritional value to the human body. Methionine can maintain the growth and development of the body and nitrogen balance. In the process of animal metabolism, it has a certain effect on the synthesis of choline and liver fat from adrenaline. Methionine can promote the metabolism of fat in the liver. It is clinically used for chronic hepatitis, cirrhosis and fatty liver. etc. prevention and treatment.
It can also be used in the adjuvant treatment of sulfonamides, arsenic or benzene poisoning, and can also be used as a choleretic drug to adjust the pH value of urine and reduce the accumulation of fat. Methionine is an important component of medical amino acid infusion, and one of the main components of 11, 14, 17, 18, and 20 amino acid infusions.
Preparation of L-Methionine
The production methods of methionine are divided into two categories: chemical methods and biological methods; chemical methods are divided into acrolein method, amino lactone method, malonate method, casein hydrolysis method, solid-liquid phase transfer catalysis method, etc. The world’s major methionine production companies have developed their own methionine production processes based on the acrolein method. The rest of the chemical methods are far behind the acrolein method in terms of process route and product yield, and are now basically abandoned.
- Acrolein method: The acrolein method is a methionine production process developed in the 1960s. The acrolein method is further divided into the hydantoin method and the cyanohydrin method.
- Hydantoin method: acrolein and methyl mercaptan undergo an addition reaction under the action of a catalyst to form methylthiopropionaldehyde; methylthiopropionaldehyde undergoes condensation reaction with NaCN or HCN, NH4HCO3 to obtain methylthioethylacetate. urea (hydantoin); then methylthioethyl hydantoin is hydrolyzed under the action of NaOH or K2CO3 to generate methionine sodium/potassium salt; further use H2SO4, HCl or CO2 acidification to obtain DL-methionine, and finally concentrate, crystallize, The methionine product was obtained by separation.
- Cyanohydrin method: The products of the cyanohydrin process are mainly liquid DL-methionine hydroxy analogs or solid DL-methionine hydroxy analogs calcium salts. Acrolein and methyl mercaptan undergo addition reaction under the action of catalyst to generate methylthiopropionaldehyde; methylthiopropionaldehyde reacts with NaCN or HCN to generate 2-hydroxy-4-methylthiobutyronitrile; hydrolyzed with concentrated sulfuric acid 2 -Hydroxy-4-methylthiobutyronitrile can obtain methionine hydroxyl analog (MHA); 2-hydroxy-4-methylthiobutyric acid can be further reacted with Ca(OH)2 or CaO to obtain methionine hydroxyl analog ( MHA-Ca).
- Aminolactone method
The amino lactone method, also known as the γ-butyrolactone method, mainly uses γ-butyl lactone as the raw material to synthesize methionine.
- Malonate method
The malonate method mainly uses 2-methylthio ethane chloride and phthalimidoethyl malonate sodium salt, ethylacetamidocyanoacetate, diethylacetamidopropyl One of the diacid salts and ethyl acetoacetate was used as the raw material to prepare methionine, and the yields were 58%, 48%, 60.5%, and 70%, respectively. ester was reacted to obtain β-methylthioethyl acetoacetate, which was then reacted with NH3, followed by hydrolysis with NaOH to obtain methionine sulfoxide. The reduction of methionine sulfoxide with calcium sulfate was equivalent to DL-methionine, and the yield reached 70%.
- Solid-liquid phase transfer catalysis
The catalyst triethylamine was added dropwise to the mixture of glycine ethyl ester hydrochloride, benzaldehyde, anhydrous magnesium sulfate and dichloromethane to prepare ethyl benzylideneaminoacetate, ethyl benzylideneaminoacetate and 2-chloroethyl acetate Ethyl methyl sulfide was synthesized under the saponification of potassium hydroxide and anhydrous potassium carbonate to synthesize benzylidene aminomethyl ethyl sulfide ethyl acetate, and finally methionine was obtained by hydrolysis with concentrated hydrochloric acid, and the yield reached 59%.
- Methionine – PubChem
- Tan Shengjun, Shao Youyuan, Li Wei. Research status and application prospect of methionine[J]. Journal of Hubei University of Technology, 2006, 21(6): 66-71.
- Yang Zhi, Yang Haiming, Wang Zhiyue, et al. The physiological function of methionine and its research and application in poultry production [J]. China Feed, 2014 (12): 21-24.