L-Hydroxyproline CAS 51-35-4
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Factory Supply L-Hydroxyproline CAS 51-35-4 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: L-Hydroxyproline Supplier & Manufacturer
L-Hydroxyproline: The Complete Guide
- Item 1: Basic Info of L-Hydroxyproline
- Item 2: What is L-Hydroxyproline?
- Item 3: L-Hydroxyproline Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of L-Hydroxyproline
- Item 6: Preparation of L-Hydroxyproline
- Item 7: Quality Control of L-Hydroxyproline
- Item 8: Hot Sale Products
- Item 9: Get L-Hydroxyproline Quotation
L-Hydroxyproline for Sale
Basic Info of L-Hydroxyproline
Basic Info
Chemical Properties
Other Info
Basic Info
Chemical Name: | L-Hydroxyproline |
Other Name: | Trans-4-Hydroxy-L-proline; (2 S ,4 R )-4-Hydroxyproline |
CAS: | 51-35-4 |
EINECS: | 200-091-9 |
Type: | Food additives; Pharmaceutical raw materials; Pharmaceutical intermediates |
Molecular Formula: | C5H9NO3 |
Molecular Weight: | 131.13 |
Chemical Properties
Melting point | 273 °C (dec.)(lit.) |
alpha | -75.5 º (c=5, H2O) |
Boiling point | 242.42°C (rough estimate) |
density | 1.3121 (rough estimate) |
vapor density | 4.5 (vs air) |
refractive index | -75.5 ° (C=4, H2O) |
storage temp. | Store below +30°C. |
solubility | H2O: 50 mg/mL |
form | Crystals or Crystalline Powder |
pka | 1.82, 9.66(at 25℃) |
color | White |
PH | 5.5-6.5 (50g/l, H2O, 20℃) |
Odor | Odorless |
optical activity | [α]25/D 75.6°, c = 1 in H2O |
Water Solubility | 357.8 g/L (20 º C) |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | L-Hydroxyproline MSDS; L-Hydroxyproline COA |
What is L-Hydroxyproline?
Hydroxyproline is a non-essential amino acid divided from another amino acid called proline. It is created by the communication of proline with ascorbic acid vitamin C. This process produces a hydroxyl team bound to a hydrogen-oxygen particle, which is affixed to a carbon particle of proline as well as converted to hydroxyproline.Trans-4-hydroxy-l-proline is an optically energetic form of 4-hydroxyproline with l-trans setup. It can be used as human metabolite, plant metabolite and also computer mouse metabolite. It is an tautomer of trans-4-hydroxy-l-proline zwitterions.
Hydroxyproline is one of the 22 amino acids called for to compose human protein and also belongs to the common human hereditary code. Hydroxyproline is created in the intestinal system. Hydroxyproline can not be generated without vitamin C. Without it, it can also trigger severe issues because the body additionally can not produce collagen, the most essential protein framework. Both proline as well as hydroxyproline are very important for the development of this crucial compound, and also an absence of either can cause serious instability of collagen in the body.
L-Hydroxyproline is a typical non-standard protein amino acid, which has high application value as the primary resources of the antiviral medication atazanavir. L-Hydroxyproline is usually made use of as a food additive (made use of as a sweetener with a fairly percentage), as well as a reasonably huge quantity of intermediates utilized as penem side chains in medication.
L-Hydroxyproline Uses
- L-Hydroxyproline is produced by hydroxylation of amino acid proline by prolyl hydroxylase after protein synthesis (as post-translational alteration). Although it is not straight incorporated right into protein, hydroxyproline make up about 4% of all amino acids found in animal cells, and also its amount is higher than that of the various other 7 translation integrated amino acids.
- Flavour Enhancer; Nutritional Enhancer. fragrance. Mainly made use of for fruit juices, revitalizing beverages, nutritional beverages, etc as biochemical reagent.
- The most fundamental cause of scurvy is a lack of vitamin C, but it is manifested through a lack of collagen, which is directly related to insufficient hydroxyproline secretion. Without it, human collagen becomes unstable and excreted in urine. A lack of collagen can lead to easy bruising of the skin, damage to connective tissue, and the potential for internal bleeding. Additionally, a lack of this amino acid can cause hair loss and gum recession.
- The body does not cause deformities during stress and movement. But a lack of hydroxyproline can also cause this protein deficiency, but not as quickly or dramatically as collagen.
- Hydroxyproline is a neutral heterocyclic protein amino acid. It is present in collagen and is as a result common in many gelatin items. Hydroxyproline is mainly utilized as a diagnostic marker for bone turnover and also liver fibrosis. In terms of therapy, hydroxyproline is being examined as an experimental medication, but it has actually been accepted in France as a mixed local gel product called ciccative to treat little and also shallow injuries.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Application of L-Hydroxyproline
Application 1
Application 2
Application 1
CN201910830617.9 discloses a method for synthesizing (4S)-N-Boc-4–methoxymethyl-L-proline, comprising using L-hydroxyproline as a starting material, and obtaining through Boc protection the step of N-Boc-L-hydroxyproline;
(2S)-N-Boc-4-oxopyrrolidine-2-carboxylic acid was obtained by dissolving N-Boc-L-hydroxyproline in a solvent and oxidizing it with TEMPO (tetramethylpiperidine nitrogen oxide). Step; Dissolve (2S)-N-Boc-4-oxopyrrolidine-2-carboxylic acid and methoxymethyltriphenylphosphonium chloride in a solvent to carry out wittig reaction to obtain (2S)-N-Boc -The step of 4-methoxymethylidene pyrrolidine-2-carboxylic acid; (2S)-N-Boc-4-methoxymethylidene pyrrolidine-2-carboxylic acid and tert-butylamine are dissolved in water and subjected to hydrogenation reaction to prepare Get (4S)-N-Boc-4–methoxymethyl-L-proline;
The reaction shortens the reaction steps; avoids the use of highly toxic cyanide, increases safety and reduces environmental protection pressure; improves atom economy and reduces waste discharge; and the cost of raw materials is greatly reduced.
Application 2
CN201810996468.9 discloses a preparation method of N-(O,O-diisopropylphosphoryl)-trans-4-hydroxy-L-proline.
Add L-Hydroxyproline to the purified water, cool down, start to add 25% sodium hydroxide solution dropwise under stirring, adjust pH=9.0-10, stir until it is clear, and stand by; dropwise into diisopropyl phosphite at low temperature Add sodium hypochlorite, rapidly stir and keep the reaction, gas-phase detection, after the DIPP reaction is complete, add sodium bisulfite; add the prepared L-hydroxyproline solution, control the pH of the reaction system to keep alkaline, and keep the reaction until the pH of the reaction solution no longer changes after the addition washed with halogenated alkane, separated into layers, the aqueous phase was made acidic with hydrochloric acid, extracted with an ester organic solvent, the organic phase was concentrated under reduced pressure, cooled and suction filtered, and dried under vacuum at 40°C to obtain a white powdery solid.
The preparation method of the invention has few side reactions, high yield, high purity and mild reaction conditions.
Preparation of L-Hydroxyproline
A preparation method of L-hydroxyproline, specifically comprising the steps:
- Add 100 g of pyroglutamic acid alcohol, 16.5 g of p-toluenesulfonic acid monohydrate, 130 g of benzaldehyde, and 350 g of toluene into a 2L reaction flask in turn, heat it to 70-120 °C for 4-6 hours, and evaporate under reduced pressure to evaporate the solvent toluene. The obtained oil was purified by column chromatography to obtain 40.5g of TSSA0200-A, HPLC: 95%, yield 23%;
- Take 30g of TSSA0200-A, add 900ml of tetrahydrofuran, add 90g of MoOPH to a 2L reaction flask, under nitrogen protection, warm to -40～-50℃, add 240g of LiHMDS dropwise, react for 6～10h, quench the reaction, and obtain 9.7 by column chromatography g TSSA0200-B, HPLC: 94.2%, yield: 30%;
- Add 5g of TSSA0200-B into a 100ml three-necked flask, add 50ml of tetrahydrofuran under nitrogen protection, cool down to -15～-20°C, add 0.8g of tetrahydroaluminum lithium, warm up to room temperature and react for 6～8h, quench the reaction, and perform column chromatography 1.5g of TSSA0200-C was obtained, HPLC: 97%, yield: 31.7%;
- Dissolve 1.5 g of TSSA0200-C with 30 ml of ethanol, add it to an autoclave, add 0.015 g of palladium carbon, pass hydrogen to 1 MPa, react for 3 h, and remove the palladium carbon by filtration to obtain 0.82 g of TSSA0200-D, yield: 96.5%;
- 0.082g of TEMPO was prepared into a 20wt% solution, 0.82g of TSSA0200-D was prepared into a 10wt% solution, pumped into a silica gel column to react for 5-10min to obtain a solution of TSSA0200-D, and 0.6g L- Hydroxyproline, yield 65.4%.
Reference
- L-Hydroxyproline – PubChem
- Gorres, Kelly L.; Raines, Ronald T. (April 2010). “Prolyl 4-hydroxylase”. Critical Reviews in Biochemistry and Molecular Biology.
- [Chinese invention, Chinese invention authorization] CN201510895948.2 A preparation method of L-hydroxyproline [public]/a preparation method of L-hydroxyproline [authorization]
L-Hydroxyproline Supplier and Manufacturer
As a l-hydroxyproline supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best l-hydroxyproline raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for l-hydroxyproline and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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* Every batch of products will be tested to ensure its quality.
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* Any inquiries will be replied to within 24 hours.
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After-Sales Service
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* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of L-Hydroxyproline
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