L-Fucose CAS 2438-80-4
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Factory Supply L-Fucose CAS 2438-80-4 with Best Price
- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: L-Fucose Supplier & Manufacturer
L-Fucose for Sale
Basic Info
Basic Info
Chemical Name: | L-Fucose |
Other Name: | Fucose; L-(-)-Fucose; 6-DEOXY-BETA-GALACTOSE; 6-DEOXY-L-GALACTOSE |
CAS: | 2438-80-4 |
EINECS: | 219-452-7 |
Type: | Plant Extracts; Sweeteners; Pharmaceuticals, Intermediates for Synthetic Materials |
Molecular Formula: | C6H12O5 |
Molecular Weight: | 164.16 |
Chemical Properties
Melting point | 150-153 °C(lit.) |
alpha | -73～-77°(D/20℃)(c=4,H2O,24hr) |
Boiling point | 211.61°C (rough estimate) |
density | 1.1738 (rough estimate) |
refractive index | -75.5 ° (C=10, H2O) |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | H2O: 0.1 g/mL, clear, colorless |
form | Powder |
pka | 12.50±0.20(Predicted) |
color | Beige to light brown to purple-grayish |
Water Solubility | Soluble in water. |
Sensitive | Hygroscopic |
Merck | 14,4279 |
BRN | 1723321 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | L-Fucose MSDS; L-Fucose COA |
What is L-Fucose?
Fucose is a hexose deoxygenase with the chemical formula of C6H12O5. It feeds on N-linked glycans on the surface of mammalian, insect and also plant cells. Fucose is the basic subunit of fucoidan. Fucose α (1 → 3) The junction core is the believed carbohydrate antigen of IgE moderated allergic reaction.
Two structural features differentiate fucose from various other six carbon sugars existing in mammals: the lack of hydroxyl teams on the 6-position (C-6) carbon (thus making it a deoxygenate) and also the L-configuration. It amounts 6-deoxy-l-galactose.
In the fucose having glycan framework, fucosylated glycans and fucose can exist as end modifications or as accessory factors for adding other sugars. Amongst human N-linked glycans, fucose is the most often associated with the lowering end β- N-acetylglucosamine α- 1,6 Connection. However, the non lowering end fucose is connected to galactose α- 1. 2 It creates H antigen, particularly the foundation of An as well as B blood group antigen.
Fucose travels through a lysosome called α- The enzyme of fucosidase is released from the polymer having fucose.
L-fucose has several possible applications in cosmetics, medicine as well as nutritional supplements
It has actually been identified that fucosylation of antibodies can minimize the binding to Fc receptors of natural killer cells, thereby minimizing antigen dependent cytotoxicity. For that reason, the fucosylated cost-free monoclonal antibody is designed to hire the body immune system to cancer cells produced in the core fucosylase (FUT8) defective cell line, therefore enhancing the cell killing power in vivo.
L-Fucose Uses
L-fucose likewise has a variety of uses in the cosmetics area, such as skin moisturizer, skin regrowth agent and anti-aging representative, or for stopping epidermal (skin) swelling.
L-fucose is one of hexoses, which plays a role in the determination of the structure of AB blood group antigen subtype, selectin mediated leukocyte endothelial adhesion and host microorganism interaction.
L-fucose is separated from seaweed. It can be used in cosmetics, medicines and dietary supplements. It is used for the determination of A and B blood antigens. It is also used to selectively mediate leukocyte endothelial adhesion and host microbial interactions. L-Fucose is also used as an anti-aging cream to accelerate wound healing and reduce allergies.
A sort of six carbon sugar. It can additionally be regarded as a methyl pentose. Most of fucose in nature is L-fucose. D-fucose is just a rare sugar, which is located in some glycoglycerides. L-fucose is mostly found in algae and also periodontal, as well as also in polysaccharides of some bacteria. The fucose has one hydroxyl group much less on the sixth carbon atom than the ordinary 6 carbon sugar, so the fucose is less hydrophilic than various other monosaccharides, however extra hydrophobic. Fucose in some blood group particles is a pen of particular blood groups. Usually, fucose is extracted from algae, initial treated with acid, neutralized, and after that separated out in the form of phenylhydrazone to get rid of phenylhydrazine α- L-fucose crystallization.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Application of L-Fucose
L-fucose regulates the activation of digestive tract Treg cells as well as bile acid manufacturing of intestinal plants by managing the immune feedback of DC cells in the body. At the same time, L-fucose can hinder digestive contraction and convulsion by regulating nNOS.
L-fucose can incorporate with viruses, microorganisms as well as contaminants to prevent them from contaminating cells, thus boosting the body’s resistance. In the research and development of new anti-cancer targeted drugs, antibody drug conjugates (ADCs) and also extracellular drug coupling systems (EDCs), which are proactively looked into as well as have made major innovations globally, all utilize CarboConnect innovation, that is, L-fucose plus amino is used to link antibodies and also medications together for screening different medication activities.
L-fucose is just one of the eight necessary sugars for human body as well as one of the oligosaccharides in human mommy’s milk (human milk likewise includes sialic acid, N-acetylglucosamine, D-glucose and also D-galactose). It is an ideal dietary supplement as well as a dietary supplement as well as immune improvement factor for infant food.
L-fucose exists in various biological niches in nature. The main natural source of L-fucose is fucoidan, a brown polysaccharide. It also exists in the polysaccharides of Astragalus, potato, kiwi, soybean, various winged peas, rape and other plants. L-fucose is a secondary component of plant cell wall polysaccharides, especially rhamnogalacturonic acid glycan, xyloglucan and arabinogalactan protein involved in it in plant cell elongation.
Response of L-Fucose
In the presence of nicotinamide adenine dinucleotide phosphate (NADP+), L-fucose is oxidized to L-fucose-1,5-lactone by L-fucose dehydrogenase, and reduced nicotinamide adenine dinucleotide phosphate (NADPH) is formed at the same time.
(L-fucose dehydrogenase)
L-fucose+NADP+–>L-fucose-1,5-lactone+NADPH+H+
The amount of NADPH formed in this reaction and the amount of L-fucose are stoichiometric. NADPH is measured by increasing the absorbance at 340 nm.
Reference
- Fucose – WikiPedia
- Roca, C (2015). “Exopolysaccharides enriched in rare sugars: bacterial sources, production, and applications”. Front Microbiol.
L-Fucose Supplier and Manufacturer
As a fucose supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best fucose raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for fucose and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of L-Fucose
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