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L-Carnosine CAS 305-84-0

Factory Supply L-Carnosine CAS 305-84-0 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: L-Carnosine Supplier & Manufacturer

Basic Info

What is L-Carnosine?

Carnosine was discovered together with carnitine by the Russian chemist Gurevitch. Studies in the UK, South Korea, Russia and other countries have shown that carnosine has strong antioxidant capacity and is beneficial to the human body. Carnosine has been shown to scavenge reactive oxygen species (ROS) and α-β unsaturated aldehydes formed during oxidative stress by excessive oxidation of fatty acids in cell membranes.

L-Carnosine is a small molecule with a left-handed structure of a natural dipeptide that is ubiquitous in nature. It is a dipeptide composed of β-alanine and L-histidine. Carnosine has cellular antioxidant, anti-aging and various physiological health functions and medical effects. It has therapeutic effects on hypertension, heart disease, senile cataracts, ulcer healing, etc. It also has anti-tumor, immune model tests, and anti-stress effects. stimulating factors and other effects.

L-Carnosine is an ingredient commonly used in health care products that seek to fight fatigue. L-carnosine has been used in Europe and the United States for many years. Experiments have found that L-carnosine can provide appropriate nutrients and energy to skin with declining functions before and after menopause. , to extend the vitality of cells. L-carnosine not only has the effect of delaying aging, but also has a powerful effect in reversing the aging pattern of cells. L-carnosine is an antioxidant that can capture oxygen free radicals. The inhibitory effect of L-carnosine on glycosylation and the protective effect of L-carnosine on normal proteins may be one of the main reasons why L-carnosine delays aging.

The Efficacy of L-Carnosine

  1. Anti-glycation
    The saccharification reaction was discovered by French chemist L.C. Maillard in 1912 and is also known as the Maillard reaction. As age increases, the body’s energy consumption slows down, and excessive intake of sugar. High-concentration sugar will accelerate the reaction with protein in the body to generate AGEs (end products of glycation), leading to skin aging and dull complexion. Research has found that L-carnosine can replace the reaction between protein and sugar, thereby restoring skin elasticity and brightening skin tone.
  2. Anti-blue light
    Blue light has stronger penetration into the skin than ultraviolet rays and can penetrate the surface and dermis of the skin, causing serious damage to the mitochondria in epithelial cells. During the continuous proliferation of aerobic free radicals, a large amount of matrix metalloproteinases will be released, which is the main culprit of the loss of collagen in the human body and the fundamental cause of skin aging and wrinkles. Researchers have used visible light (480J/cm2) to irradiate human epidermal melanocytes to verify the efficacy of L-carnosine. The results show that L-carnosine has an inhibitory effect on pigmentation caused by visible light.
  3. Antioxidant
    When oxygen participates in the respiratory chain of organisms, it also produces oxygen free radicals. As the body’s antioxidant enzyme activity weakens, oxygen free radicals increase excessively in the body, which can attack cell membranes, proteins and nucleic acids, leading to skin aging. In 2002, scientists verified the antioxidant effect of L-carnosine on lecithin liposomes through an orthogonal experimental method. The results showed that L-carnosine enhanced the antioxidant effect of lecithin liposomes. After in-depth research at a later stage, it was further confirmed that L-carnosine can increase the collagen content and collagen fibers of the skin and improve the skin environment.

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This is William, CEO of Zhishang Chemical Co., Ltd.

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The Role of Carnosine

Partial Relationship between Carnosine and Anti-aging

  1. Carnosine and aging
    Previous reports have suggested that carnosine may be an anti-aging agent (Boldyrev et al., 1999a; Hipkiss, 1998; Hipkiss et al., 2001). This idea is based on: (i) An observation report completed in Australia around 1990 but finally published in 1994, in which it was believed that carnosine can not only delay the aging of cultured human fibroblasts, but also reverse it by promoting rejuvenation. phenotype of aging (McFarland and Holliday, 1994, 1999), and (ii) a substantial study conducted by Russian laboratories in the 1980s and 1990s on the antioxidant activity of dipeptides and their protective function against ischemic lesions of the heart and kidneys Research (see Boldyrev, 1993; Boldyrev et al., 1993, 1995, 1997; Quinn et al., 1992; and references therein). A later study showed that fibroblasts containing carnosine protected telomeres from shortening (Shao et al., 2004). The anti-aging effects of carnosine were later observed in accelerated aging mice and fruit flies (Yuneva et al., 1999, 2002). Carnosine appears to be specifically associated with long-lived, postmitotic tissues such as muscle and nerves, which is at least consistent with the idea that the dipeptide does not compromise cell survival and helps ensure its longevity.
  2. Carnosine and causes of aging
    Explanations for the causes of aging remain somewhat controversial. First, biogerontologists reject the idea that aging is a genetically programmed process with growth and development, since most wild animals die from predation, starvation, or disease before becoming noticeably older. Genetic selection specifically to program aging would therefore have no evolutionary advantage. The more common view is that aging is the result of a breakdown in molecular homeostasis due to the chronic effects of destabilizing forces (endogenous or exogenous) to which all cells and organisms are continuously subjected. In other words, organisms evolve to survive long enough to replicate their genes, and during this time entropy must be controlled or its effects must be eliminated. Therefore, the changes we call aging are not thought to have evolutionary significance, but are the result of the eventual failure of longevity genes, which ensure long enough survival for the organism to replicate successfully. Consistent with this idea, there is often a correlation between the longevity of an organism and its ability to withstand certain external stresses, such as heat or radiation.

    Several possible mechanisms have been proposed to explain the cause of aging. These mechanisms include environmental and endogenous factors that affect an organism’s ability to survive by causing genetic changes (e.g., DNA damage and telomere shortening), modifying gene expression, increasing oxidative stress, impairing energy supply, and promoting differential protein accumulation. There is evidence that carnosine may, at least to some extent, ameliorate these possible causes of aging (Hipkiss, 1998).

References

  1. Alan R. Hipkiss (2009). “Chapter 3: Carnosine and Its Possible Roles in Nutrition and Health”. Advances in Food and Nutrition Research.
  2. Bate-Smith, EC (1938). “The buffering of muscle in rigor: protein, phosphate and carnosine”Journal of Physiology

L-Carnosine Supplier and Manufacturer

As a l-carnosine supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best l-carnosine raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for l-carnosine and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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