Itaconic acid CAS 97-65-4

Factory Supply Itaconic acid CAS 97-65-4 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Itaconic acid Supplier & Manufacturer

Basic Info of Itaconic acid

What is Itaconic acid?

Itaconic acid is a five-carbon dicarboxylic acid, also known as methylene succinic acid and methylene succinic acid. It is one of three products when citric acid is distilled, the other two being citraconic acid and mesaconic acid. The word Itaconic is a translocation of the word aconitic.

Itaconic acid (itaconate) is one of the best examples of metabolic reprogramming during immunity. It is synthesized in macrophages by cis-aconitate in the tricarboxylic acid cycle (TCA cycle), which are activated by a variety of factors, especially lipopolysaccharide (LPS), and other Toll Like receptor (TLR) ligands and cytokines, such as type I and type II interferons, these stimuli increase aconitate decarboxylase 1 (ACOD1; also known as CAD), originally called the immune response Gene 1 protein (IRG1), cis-aconitic acid is diverted from the TCA cycle, repurposed to produce itaconic acid). The current study shows that itaconic acid is an important immune metabolite with profound effects on immunity, host defense and tumorigenesis.

Itaconic acid Uses

  1. As a copolymer of polyacrylonitrile fiber, it can also be used to prepare plasticizer, lubricating oil additive and so on.
  2. Itaconic acid can be used as a chemical reagent, a monomer for synthetic fibers and synthetic resins, a binder, and the like.
  3. Polyvalent metal oxides can be used as dental adhesive, which has good extrusion performance, strong adhesion and good physiological adaptability. 
  4. Itaconic acid has an inhibitory effect on isocitrate lyase, which is a key part of glyoxylate shunt, so itaconic acid can be used as an antibacterial agent.
  5. Itaconic acid inhibits fructose-6-phosphate 2-kinase and has a direct effect on central carbon metabolism. In rats, an itaconate diet resulted in decreased visceral fat accumulation due to inhibition of glycolytic flux.
  6. Itaconic acid can be an inhibitor of metabolic pathway.

If you want to buy Itaconic acid, pls contact us to get a free quote.

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This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

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  1. Steiger, Matthias Georg; Blumhoff, Marzena Lidia; Mattanovich, Diethard; Sauer, Michael (2013-01-01). “Biochemistry of microbial itaconic acid production”Frontiers in Microbiology.
  2. Cordes, Thekla; Michelucci, Alessandro; Hiller, Karsten (2015). “Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite”Annual Review of Nutrition.

Itaconic acid Supplier and Manufacturer

As a Itaconic acid supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best Itaconic acid raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for Itaconic acid and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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Comments from Customers

Chancelle Makongo
Chancelle MakongoReland
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Its been an absolute pleasure working with this supplier they offered me kindness, support, kept in contact with right up util receive the product the quality is excellent and shipping was fast. overall | am happy and will be returning back for more.
Lio Lechat
Lio LechatSwitzerland
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I can only advise to do business with because the service is excellent!
Thomas Rsel
Thomas RselAustralia
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Great company! thanks from Australia for good product quality, correct product, good customer service using chat.. delivery speed was ok, via FedEx. the Alibaba App finally makes it safer, so good companies like Shandong Zhi Shang can do business with us, I don't have to worry now with Alipay. Everything is safe for me now, I can't go wrong. frst time payments can just use card, the seller never knows your details, only Alibaba does the payment, so the risk is gone, delivery on time is guaranteed, and because the seller can't see your card details, scammers can't use this system, only good companies that do the right thing can make money here. it really is a much better system now.
Daniel Simonson
Daniel SimonsonUnited States
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Great service - the order arrived sealed in a metal can, perfect for shipping. The can was dented but intact.Shipping from China is rough!
rintero ariura
rintero ariuraJapan
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The product was good and the person who dealt with it was kind!
Rene van Buuren
Rene van BuurenJnited Kingdom
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Mary once again exceeded expectations with her friendly, helpful, professional service. I feel very confdent in this company and its products and will definitely be placing further orders in the future.
Barbara Mohar
Barbara MoharSlovenia
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I general, was very satisfied with the supplier. Basic analyzes (m.p.. FTIR) of the product in our facility confirmed its high quality. Further analyzes are planned, but due to the COVID-19 pandemic, most laboratories in Slovenia are closed.
Sergio Masala
Sergio MasalaSpain
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At this moment I did two mini batches of soap with a very good result. But Ihave to improve my procedure in this techinc. Thank you.
Bassam Zaidan
Bassam ZaidanSaudi Arabia
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The product has a very good quality and it was what we were looking for. shipping was on-time even due COVID-19. the supplier was very responsive and with us all the way.

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