Itaconic acid CAS 97-65-4

Factory Supply Itaconic acid CAS 97-65-4 with Best Price

  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available

Basic Info of Itaconic acid

What is Itaconic acid?

Itaconic acid is a five-carbon dicarboxylic acid, also known as methylene succinic acid and methylene succinic acid. It is one of three products when citric acid is distilled, the other two being citraconic acid and mesaconic acid. The word Itaconic is a translocation of the word aconitic.

Itaconic acid (itaconate) is one of the best examples of metabolic reprogramming during immunity. It is synthesized in macrophages by cis-aconitate in the tricarboxylic acid cycle (TCA cycle), which are activated by a variety of factors, especially lipopolysaccharide (LPS), and other Toll Like receptor (TLR) ligands and cytokines, such as type I and type II interferons, these stimuli increase aconitate decarboxylase 1 (ACOD1; also known as CAD), originally called the immune response Gene 1 protein (IRG1), cis-aconitic acid is diverted from the TCA cycle, repurposed to produce itaconic acid). The current study shows that itaconic acid is an important immune metabolite with profound effects on immunity, host defense and tumorigenesis.

Itaconic acid Uses

  1. As a copolymer of polyacrylonitrile fiber, it can also be used to prepare plasticizer, lubricating oil additive and so on.
  2. Itaconic acid can be used as a chemical reagent, a monomer for synthetic fibers and synthetic resins, a binder, and the like.
  3. Polyvalent metal oxides can be used as dental adhesive, which has good extrusion performance, strong adhesion and good physiological adaptability. 
  4. Itaconic acid has an inhibitory effect on isocitrate lyase, which is a key part of glyoxylate shunt, so itaconic acid can be used as an antibacterial agent.
  5. Itaconic acid inhibits fructose-6-phosphate 2-kinase and has a direct effect on central carbon metabolism. In rats, an itaconate diet resulted in decreased visceral fat accumulation due to inhibition of glycolytic flux.
  6. Itaconic acid can be an inhibitor of metabolic pathway.

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Chancelle MakongoReland
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Its been an absolute pleasure working with this supplier they offered me kindness, support, kept in contact with right up util receive the product the quality is excellent and shipping was fast. overall | am happy and will be returning back for more.
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Great company! thanks from Australia for good product quality, correct product, good customer service using chat.. delivery speed was ok, via FedEx. the Alibaba App finally makes it safer, so good companies like Shandong Zhi Shang can do business with us, I don't have to worry now with Alipay. Everything is safe for me now, I can't go wrong. frst time payments can just use card, the seller never knows your details, only Alibaba does the payment, so the risk is gone, delivery on time is guaranteed, and because the seller can't see your card details, scammers can't use this system, only good companies that do the right thing can make money here. it really is a much better system now.
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At this moment I did two mini batches of soap with a very good result. But Ihave to improve my procedure in this techinc. Thank you.
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