Isopropyl Nitrite CAS 541-42-4

In a reaction flask equipped with a stirrer, a thermometer and a dropping funnel, add 227.7g (3.3mol) sodium nitrite and 1L water, stir to dissolve, cool to -5°C in an ice-salt bath, and slowly add dropwise to 0. A solution of 147 g of concentrated sulfuric acid, 60 mL of water, and 180 g (3.0 mol) of isopropanol (2) at a temperature of ℃. The dropping rate was controlled at the temperature of the reaction solution at -2 to 0°C, and the addition was completed in about 2 hours. Low temperature reaction 1.5h.

The organic layer was separated, washed with saturated brine containing a small amount of sodium bicarbonate, dried over anhydrous magnesium sulfate, distilled under reduced pressure, and the fractions at 39-40°C/99.08kPa were collected to obtain 190 g of isopropyl nitrite (1), which was collected rate of 71%.