Isonicotinic acid CAS 55-22-1

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  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Isonicotinic acid Supplier & Manufacturer

Basic Info of Isonicotinic acid

What is Isonicotinic acid?

4-Picolinic acid, also known as isonicotinic acid, chemical name pyridine-4-carboxylic acid, molecular formula is C6H5NO2, structural formula is: white needle-like crystalline powder, odorless; melting point 319 ° C, 260 ° C (2kPa) sublimation; soluble in hot water , slightly soluble in cold water, almost insoluble in benzene, ether, etc. The substance is an amphoteric compound, soluble in both acid and base, reacts with acid to form pyridinium salt, and reacts with base to form carboxylate. Pyridinecarboxylic acids are all internal salts in aqueous solution, that is, exist in the form of zwitterions. Isonicotinic acid is a widely used intermediate.

Isonicotinic acid can be used as a pharmaceutical intermediate. There are many methods for synthesizing isonicotinic acid, which are mainly divided into oxidation method, hydrolysis method and biocatalysis method. The oxidation method is divided into potassium permanganate oxidation method, nitric acid oxidation method, catalytic air oxidation method, ozone oxidation method and other traditional chemical oxidation methods and electrochemical oxidation methods.

Isonicotinic acid Uses

  1. Isnicotinic acid is a widely used intermediate. Mainly used as isoniazid (ramiphen), terfenadine, isoniacic acid and other first-line anti-tuberculosis drugs raw materials, can also be used as preservatives, electroplating additives, photosensitizers. Resin stabilizer, PVC heat stabilizer, non-ferrous metal flotation agent, etc.
  2. Isoniazid can be obtained by condensation and melting dehydration of isoniazid and hydrazine hydrate. Isoniazid has good antibacterial effect on mycobacterium tuberculosis, good efficacy, small dosage, relatively low toxicity. It is used to treat all forms of tuberculosis. It can also be used for advanced tuberculous meningitis and other extrapulmonary tuberculosis, during the period of dissolution and spread, and during the period of improved absorption. These preparations include tablets and injections.
  3. It is used as a pharmaceutical intermediate, mainly for the production of anti-tuberculosis drug isoniazid, and also for the synthesis of derivatives such as amides, hydrazides, and esters.
  4. Isonicotinic acid, also known as pyridine 4-carboxylate, is an intermediate of the plant growth regulator Trexamine, as well as an intermediate of isoniazid, a medicinal anti-tuberculosis drug.
  5. In addition, isonicotinic acid can also be used to synthesize other organic compounds or prepare chemical materials. Examples of its applications are as follows:

The method includes the following steps:

  • Take 4-picoline as raw material, use water as solvent, and oxidize it to 4-picolinic acid with potassium permanganate, wherein the molar ratio of 4-picoline to potassium permanganate is 1:2.1 -2.3, the oxidation temperature is 75-80 ℃, heating for 35min, the reaction is completely adjusted to the acidity of the reaction solution, and then cooled and filtered to obtain 4-picolinic acid;
  • 4-picolinic acid and methanol generate methyl 4-picolinate under acidic conditions, wherein the molar ratio of 4-picolinic acid and methanol is 1:1.3;
  • reducing methyl 4-picolinate is 4-pyridinemethanol;
  • 4-pyridinemethanol reacts with thionyl chloride to obtain the target product 4-chloromethylpyridine hydrochloride, and the molar ratio of 4-pyridinemethanol to thionyl chloride is 1:1.1-1.3.

Include the following components by weight:
20-35 parts of cis-isoprene rubber, 10-13 parts of carbon black, 8-12 parts of polyoxypropylene glyceryl ether, 7-10 parts of potassium tetraborate, 9-14 parts of polyisobutylene, dimethylaminoethanol dianisole 10-15 parts, 6-10 parts of petroleum resin, 3-8 parts of tetraethylammonium iodide, 7-16 parts of methylprednisolone acetate, 2-6 parts of zinc molybdate, 5 parts of tetraethyl silicate -9 parts, 1-3 parts of expanded perlite, 2-4 parts of manganese antimonide, 9-12 parts of polyethylene wax, 12-15 parts of 4-picolinic acid.
The waterproof material can meet the needs of waterproof operation in a high temperature environment, and has wide application prospects.

Each substance containing the following weight components:
50-70 parts of base oil, 10-15 parts of 2-decen-2-ol, 5-9 parts of chloroform, 3-7 parts of 2-amino-2-methylpropane, 1H-imidazole-4-ethylamine 6-10 parts, 12-16 parts phthalimide, 4-8 parts calcium lignosulfonate, 2-5 parts zinc dibutyl dithiocarbamate, 10-ethylene glycol monomethyl ether 15 parts, 8-13 parts of propylparaben, 7-13 parts of dicyclopentadiene, 4-9 parts of 4-picolinic acid, 3-8 parts of 2,4-dinitrophenol.
By using a variety of chemical substances to modify the base oil, it can adapt to the harsh environment of severe cold and meet the requirements of lubricating use in this environment.

Include the following components by weight:
40-80 parts of fiber material, 10-20 parts of polyisoprene, 15-22 parts of silicone rubber, 8-15 parts of folin isobutyrate, 10-18 parts of polybrene, 7-4-picolinic acid 14 parts, 2-6 parts of hexamethylcyclotrisiloxane, 4-8 parts of urea, 1-4 parts of calcium chloride, 6-12 parts of isocyanate.
The textile fibers have good electrical conductivity, and people can directly control smart devices through the textiles prepared from the textile fibers, and have strong practical performance.

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This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

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  1. CN201310004545.5 Isonicotinate ester and its preparation method
  2. Isonicotinic+Acids at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Isonicotinic acid Supplier and Manufacturer

As a isonicotinic acid supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best isonicotinic acid raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for isonicotinic acid and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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Chancelle Makongo
Chancelle MakongoReland
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Its been an absolute pleasure working with this supplier they offered me kindness, support, kept in contact with right up util receive the product the quality is excellent and shipping was fast. overall | am happy and will be returning back for more.
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Lio LechatSwitzerland
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I can only advise to do business with because the service is excellent!
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Thomas RselAustralia
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Great service - the order arrived sealed in a metal can, perfect for shipping. The can was dented but intact.Shipping from China is rough!
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rintero ariuraJapan
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The product was good and the person who dealt with it was kind!
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Mary once again exceeded expectations with her friendly, helpful, professional service. I feel very confdent in this company and its products and will definitely be placing further orders in the future.
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I general, was very satisfied with the supplier. Basic analyzes (m.p.. FTIR) of the product in our facility confirmed its high quality. Further analyzes are planned, but due to the COVID-19 pandemic, most laboratories in Slovenia are closed.
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Sergio MasalaSpain
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At this moment I did two mini batches of soap with a very good result. But Ihave to improve my procedure in this techinc. Thank you.
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Bassam ZaidanSaudi Arabia
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The product has a very good quality and it was what we were looking for. shipping was on-time even due COVID-19. the supplier was very responsive and with us all the way.

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