Huperzine A CAS 102518-79-6

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  • Appearance: Yellow-brown powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Huperzine A Supplier & Manufacturer

Basic Info of Huperzine A

What is Huperzine A?

Huperzine A is a natural plant extract. Compared with similar AD treatment drugs approved by the US FDA, Huperzine A has a unique chemical structure and has extremely high selectivity to inhibit acetylcholinesterase in the brain and enhance cholinergic in the brain. function of neurons. In addition, Huperzine A has obvious effects on improving memory and improving cognitive ability.

Huperzine A has a small relative molecular weight, high lipid solubility, and is easy to pass through the blood-brain barrier. After entering the central nervous system, it is mostly distributed in the frontal lobe, temporal lobe, hippocampus and other parts of the brain. Its pharmacological effects have multiple targets. In addition to inhibiting the activity of acetylcholinesterase, it can also antagonize oxidative stress and apoptosis induced by β-amyloid peptide (Aβ), hydrogen peroxide and other neurotoxins, by activating the protein kinase C (PKC) signal transduction pathway. Activation of α-secretase promotes the decomposition of β-amyloid precursor protein (APP) in a non-amyloidogenic manner to produce sAPPα, reducing Aβ-mediated toxicity, while sAPPα can effectively promote cell proliferation, axonal growth, and protect nerves. cell.


Huperzine A Uses

Neuroprotective Effects of Huperzine A

Huperzine A (Hup A), in addition to its significant cholinesterase inhibitory effect, also has extensive neuroprotective effects. Its protective effect also plays an important role in the treatment of AD and against the damage of neurotoxic substances.

The ratio of pro-apoptotic and anti-apoptotic proteins in the Bcl-2 protein family determines whether cells undergo apoptosis after being stimulated by apoptotic signals. When the Bcl-2/Bax value decreases, Bax forms homodimers to induce cell apoptosis; when the Bcl-2/Bax value increases, Bax and Bcl-2 form heterodimers, causing Bcl-2 to inhibit cells. Apoptotic function. Zhu Ning et al.¹ found in rat experiments that when neural stem cells were stimulated by Aβ1-42-mediated inflammatory response, the expression of Bcl-2 and Bax was the highest in each group, and the Bcl-2/Bax value was the highest in each group. lowest. After pretreating microglia with Hup A, liquid phase chip detection found that the secretion of inflammatory factors was reduced. At the same time, the Bcl-2/Bax value was significantly higher than that in the Aβ group, which inhibited the apoptosis of neural stem cells. Both Western blotting and flow cytometry results indicate that Hup A can inhibit the apoptosis of neural stem cells.

The main mechanism of Hup A against organophosphorus poisoning is: Hup A reversibly binds to acetylcholinesterase when administered in advance, thereby preventing the irreversible combination of organophosphorus compounds and acetylcholinesterase. Compared with other reversible cholinesterase inhibitors such as pyridostigmine bromide, Hup A has two major advantages: On the one hand, Hup A can pass the blood-brain barrier, thereby protecting acetylcholinesterase in the brain. On the other hand, butyrylcholinesterase and carboxylesterase may be endogenous organophosphorus scavengers. Hup A can selectively inhibit plasma erythrocyte acetylcholinesterase but has no inhibitory effect on butyrylcholinesterase. Therefore, the selectivity of Hup A contributes to the prevention of organophosphorus poisoning.

Glutamate is an agonist of N-methyl-D-aspartate (NMDA) receptors. Excitation of NMDA receptors can increase the influx of calcium ions into neurons, and excessive calcium ion concentration can lead to cell death. . Hup A can reduce the toxicity of glutamate to nerve cells and improve cell survival rate. It has the strongest protective effect on mature neuron cells, because mature neuron cells have a larger number of NMDA receptors. The mechanism of antagonizing glutamate may be that after NMDA receptor stimulation, Hup A blocks its signal transduction channel somewhere downstream, thereby preventing cell death caused by glutamate. In addition, Hup A’s protective effect on nerve cells may also be There is glutamate receptor-mediated involvement.

Hup A protects neuronal cells against the toxicity produced by beta-amyloid and increases superoxide dismutase (SOD) production. Rat primary cortical cells cultured in vitro were incubated under the conditions of Aβ25-35 (amino acid residues 25-35 of β-amyloid protein fragments). Cell apoptosis can be observed, cell viability is significantly reduced, and neuronal cell morphology changes. changes and fragments of its DNA. Early administration of Hup A can significantly improve cell survival rate and prevent nuclear fragmentation. The mechanism is that Hup A inhibits the formation of reactive oxygen species (ROS reactive oxygen species) and the activity of caspase-3 enzyme.

Studies have shown that NO can inhibit the growth of human neurocytoma SK-N-SH line cells and induce cell apoptosis. Hup A, ginkgolactone A and B can block the apoptosis and growth inhibitory effects of sodium nitroprusside (NO donor) on SK-N-SH cells. In addition, Hup A and ginkgolactone A and B can also inhibit the production of NO in mouse glial cells and the production of NO in human and mouse astrocytes.


  1. Huperzine A – WikiPedia
  2. Zhang Lei et al. Research progress of huperzine A. Chinese Herbal Medicine. 2005, 36(9):1422-1426.
  3. Lim WH, Goodger JQ, Field AR, Holtum JA, Woodrow IE (September 2010). “Huperzine alkaloids from Australasian and southeast Asian Huperzia”Pharmaceutical Biology

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Huperzine A for Sale

This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Huperzine A Supplier and Manufacturer

As a Huperzine A supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best Huperzine A raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for Huperzine A and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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Chancelle Makongo
Chancelle MakongoReland
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Its been an absolute pleasure working with this supplier they offered me kindness, support, kept in contact with right up util receive the product the quality is excellent and shipping was fast. overall | am happy and will be returning back for more.
Lio Lechat
Lio LechatSwitzerland
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I can only advise to do business with because the service is excellent!
Thomas Rsel
Thomas RselAustralia
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Great company! thanks from Australia for good product quality, correct product, good customer service using chat.. delivery speed was ok, via FedEx. the Alibaba App finally makes it safer, so good companies like Shandong Zhi Shang can do business with us, I don't have to worry now with Alipay. Everything is safe for me now, I can't go wrong. frst time payments can just use card, the seller never knows your details, only Alibaba does the payment, so the risk is gone, delivery on time is guaranteed, and because the seller can't see your card details, scammers can't use this system, only good companies that do the right thing can make money here. it really is a much better system now.
Daniel Simonson
Daniel SimonsonUnited States
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Great service - the order arrived sealed in a metal can, perfect for shipping. The can was dented but intact.Shipping from China is rough!
rintero ariura
rintero ariuraJapan
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The product was good and the person who dealt with it was kind!
Rene van Buuren
Rene van BuurenJnited Kingdom
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Mary once again exceeded expectations with her friendly, helpful, professional service. I feel very confdent in this company and its products and will definitely be placing further orders in the future.
Barbara Mohar
Barbara MoharSlovenia
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I general, was very satisfied with the supplier. Basic analyzes (m.p.. FTIR) of the product in our facility confirmed its high quality. Further analyzes are planned, but due to the COVID-19 pandemic, most laboratories in Slovenia are closed.
Sergio Masala
Sergio MasalaSpain
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At this moment I did two mini batches of soap with a very good result. But Ihave to improve my procedure in this techinc. Thank you.
Bassam Zaidan
Bassam ZaidanSaudi Arabia
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The product has a very good quality and it was what we were looking for. shipping was on-time even due COVID-19. the supplier was very responsive and with us all the way.

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