(-)-Huperzine A CAS 102518-79-6
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- Appearance: Yellow-brown powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
(-)-Huperzine A: The Complete Guide
Index of (-)-Huperzine A Contents
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Basic Info of (-)-Huperzine A
Huperzine Potassium A; Huperzine A;-Huperzine A A, Selaginella pine test, Haberine; Huperzine A, derived from Huperzine serrata; Huperzine A extract; Perzine A; Perrinthine A ((±)-Huperzine A, Selaginella, Haberine); (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10- Tetrahydro-7-methyl-5,9-methylenecyclooctano(B)pyridin-2(1H)one
What is (-)-Huperzine A?
Huperzine A is a natural plant extract. Compared with similar AD treatment drugs approved by the US FDA, Huperzine A has a unique chemical structure and has extremely high selectivity to inhibit acetylcholinesterase in the brain and enhance cholinergic in the brain. function of neurons. In addition, Huperzine A has obvious effects on improving memory and improving cognitive ability.
Huperzine A has a small relative molecular weight, high lipid solubility, and is easy to pass through the blood-brain barrier. After entering the central nervous system, it is mostly distributed in the frontal lobe, temporal lobe, hippocampus and other parts of the brain. Its pharmacological effects have multiple targets. In addition to inhibiting the activity of acetylcholinesterase, it can also antagonize oxidative stress and apoptosis induced by β-amyloid peptide (Aβ), hydrogen peroxide and other neurotoxins, by activating the protein kinase C (PKC) signal transduction pathway. Activation of α-secretase promotes the decomposition of β-amyloid precursor protein (APP) in a non-amyloidogenic manner to produce sAPPα, reducing Aβ-mediated toxicity, while sAPPα can effectively promote cell proliferation, axonal growth, and protect nerves. cell.
(-)-Huperzine A Uses
Huperzine A has a highly selective inhibitory effect on acetylcholinesterase, thereby reducing the hydrolysis of acetylcholine, and by activating N receptors or M receptors on presynaptic membranes and antagonizing M receptors on postsynaptic membranes, choline Enhanced functionality. In addition, by supplementing acetylcholine precursors, the synthesis of acetylcholine is increased, and the cholinergic neurons are excited, thereby enhancing the learning and memory ability of AD patients and improving the cognitive and behavioral function. There are various molecular subtypes of acetylcholinesterase. There are G4 and G1 types in the mammalian brain. G4 type is the main type, and about 60% to 90% are distributed in the extracellular fluid of nerves, especially in the synaptic space.
Zhao et al. compared the inhibitory effects of huperzine A, tacrine, donepezil, rivastigmine and physostigmine on different subtypes of AChE in rat intracranial cortex, hippocampus and striatum. The inhibitory effect of A on G4-type acetylcholinesterase is significantly stronger than that of G1-type, that is, Huperzine A has a higher affinity for G4-type. It can be seen that Huperzine A can fully inhibit acetylcholinesterase in the synaptic cleft of acetylcholinergic neurons, increase the concentration of acetylcholine, and has a more obvious improvement effect on cognitive impairment and memory loss in AD patients.
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