High quality CAS:1397-89-3.Amphotericin B

Basic Info

Model No.: LYN-1397-89-3

CAS: 1397-89-3

Name:: Amphotericin B

Shelf Life: 2 Years

Sample: Available

Additional Info

Packaging:  25kg/Drum

Productivity: 10000kg

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

HS Code: 1060.24000

Port: Shanghai,Tianjin,Qingdao

Product Description

High quality CAS:1397-89-3.Amphotericin B 

Product Introduction

Product Name Amphotericin B

Molecular Formula C47H73NO17

Molecular Weight 924.079

CAS Registry Number 1397-89-3

EINECS 215-742-2

Density 1.34g/cm3

Melting point >170°C

Boiling point 1140.365°C at 760 mmHg

Refractive index 1.614

Flash point 643.47°C

Water solubility <0.1 g/100 mL at 21°C

Vapour Pressur 0mmHg at 25°C


Amphotericin B (FungilinFungizoneAbelcetAmBisomeFungisomeAmphocilAmphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentousbacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical’s amphoteric properties. Two amphotericins, amphotericin A and amphotericin B are known, but only B is used clinically, because it is significantly more activein vivo. Amphotericin A is almost identical to amphotericin B (having a double C=C bond between the 27th and 28th carbons), but has little antifungal activity.

Currently, the drug is available as plain amphotericin B, as a cholesteryl sulfate complex (ABCD), as a lipid complex (ABLC), and as a liposomal formulation (LAmB). The latter formulations have been developed to improve tolerability for the patient, but may show considerably different pharmacokinetic characteristics compared to plain amphotericin B.







Yellow to orange powder, odorless or practically so.

Yellow powder


Insoluble in water and in ether,slightly soluble in methanol


Identification A: (UV)

Conforms to standard; absorbance in the range of 240nm to 320nm


Identification B: (UV/Vis )

Conforms to standard; absorbance in the range of 320nm to 400nm


Loss on drying

Not more than 5.0%


Residue on Ignition

Not more than 3.0%


Limit amphotericin A

Not more than 15.0%

Not detected

Assay (microbial)

Not less than 750 μg/mg calculated on the dried basis

894 μg/mg

Residual Solvents


Not more than 5000 ppm



Not more than 5000 ppm



Complies with USP34



Oral preparations of amphotericin B are used to treat thrush; these are virtually nontoxic, in contrast to typical intravenous therapy (IV) doses.

One of the main intravenous uses is in treating various systemic fungal infections (e.g., in critically ill, comorbidly infected or immunocompromised patients), including cryptococcal meningitis.

Amphotericin B is also commonly used in tissue culture to prevent fungi from contaminating cell cultures. It is usually sold in a concentrated solution, either on its own or in combination with the antibiotics penicillin and streptomycin.


Another IV use is as a drug of last resort in otherwise-untreatable parasitic protozoan infections such as visceral leishmaniasis and primary amoebic meningoencephalitis.                


0.5kgs/Al-foil bag 

1.0kgs/Al-foil bag 

2.0kgs/Al-foil bag 

5.0 kgs/Al-foil bag

25.0 kgs/drum

or upon customers’ request

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