High quality 3-Chloro-2-methylaniline cas 87-60-5

High quality 3-Chloro-2-methylaniline cas 87-60-5

3-Chloro-2-methylaniline, is a versatile organic building block, used for the synthesis of various pharmaceutical compounds, and therapeutic agents. For instance, it is used for the synthesis of 1-[2-(10-dihydroartemisininoxy) ethyl]-3-phenylurea derivatives as potential agents against cancer.

Production method
O-nitrotoluene by chlorination, reduction derived.
1. Chlorination In o-nitrotoluene, add 2% ferric chloride as a catalyst, pass chlorine gas at 50-60°C, until the relative density of the reaction solution reaches 1.27-1.29 (50°C), use 5% It was washed with hydrochloric acid, washed with water, and finally adjusted to pH 7 with a caustic soda. Divide the water layer and evaporate the water, then vacuum distillation, collecting 120-150 ° C (5.33-8.0kPa) fractions, cooling and crystallization, filtration, 2-chloro-6-nitrotoluene.
2. Reduction Add hydrochloric acid and iron powder to the reaction kettle with stirring and heating until 90°C. Slowly add the melted 2-chloro-6-nitrotoluene, complete the addition, and reflux for 3 hours. Cool, add alkali to adjust the pH to 8, steam distillation to give 3-chloro-o-toluidine.
use
It is an important raw material for synthetic dyes and pesticides. It can synthesize dye DB-50, and can produce herbicides for paddy fields to kill crickets.

Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.

3> Fragrance And Spices: Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, resins, additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion.

6> Pharmaceutical Intermediates: The so-called pharmaceutical intermediates, refers to the production of pharmaceutical products in the process, the use of raw materials, materials, accessories and other intermediate products.

7> Agricultural Chemicals: Research and agriculture related chemical, including pesticide, plant growth regulator, fertilizer, compound fertilizer, herbicide etc.