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Heptafluorobutyric Acid CAS 375-22-4

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  • Appearance: Yellow liquid
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Heptafluorobutyric Acid Supplier & Manufacturer

Basic Info

What is Heptafluorobutyric Acid?

Perfluorobutyric acid is also known as heptafluorobutyric acid, its molecular formula is: C4HF7O2, its melting point is -17.5°C, its boiling point is 120°C, its relative density is 1.651, and its refractive index is 1.3032. It is a colorless liquid at room temperature, with an odor like butyric acid and strong acidity. Perfluorobutyric acid is stable in nature and can undergo salt-forming reactions, esterification reactions, substitution reactions, dehydration reactions and reduction reactions of alcoholic hydroxyl groups. Perfluorobutyric acid can be regarded as the product obtained by replacing all the hydrogen atoms in the butyric acid molecule with fluorine atoms. The industrial preparation of perfluorobutyric acid adopts the electrochemical fluorination method, using butyryl chloride as the starting material. Water hydrogen fluoride undergoes electrolytic fluorination reaction, and the anode product is neutralized and acidified to obtain the product. It is mainly used as a surface active agent, but also as an insecticide, ester catalyst, acidifying agent, organic intermediate and synthetic rubber.

Perfluorobutyric acid and also its derivatives are a course of chemical intermediates, which can be used as intermediates for new medicines, gunpowder, as well as flavors, as well as can likewise be utilized as resources pol or ingredients for the synthesis of tural-new brand materials. At the same time, they can additionally be used as natural solvents. As an example, after perfluorooctanoic acid is contributed to polymer molecules as a reagent giving fluorine-containing teams, fiber textiles with water resistant and dustproof generated by homes can be the polymer.

Heptafluorobutyric Acid Uses

  1. Heptafluorobutyric acid (HBFA) is commonly utilized to detoxify neuropeptides because of its superb resolution. Application of Heptafluorobutyric Acid as a Volatile Ion Pair Reagent in the Splitting Up of SB-223070 by High Performance Liquid Chromatography John K.
  2. Heptafluorobutyric acid is a strong acid as well as ion set reagent used in logical chemistry in a similar fashion to trifluoroacetic acid (TFA), specifically by HPLC and also gas chromatography/mass spectrometry (GC/MS). The solid acidity of HFBA makes sure that other acidic groups on biomolecules, such as carboxylic acid, remain protonated, so biomolecular samples can connect with organic solvents in processes such as reverse stage chromatography. The longer alkyl chain of HFBA makes it extra hydrophobic than TFA, so HFBA can be used for samples with stronger hydrophobicity.
  3. HFBA (0.1%) has been made use of as a mobile phase in the HPLC/LC-MS protocol for the detection of aquatic planktonic microbial side cells. LC/ESI-MS has been published to explore the impacts of numerous acids, consisting of HFBA, on the reverse phase separation of intact proteins. A modified version of the peptide ladder sequencing method making up allyl isothiocyanate and HFBA has been reported.
  4. Heptafluorobutyric acid is an ion pair reagent used in reverse phase HPLC. It is used for the sequencing, synthesis, and dissolution of proteins and peptides. It is used as a mobile phase modifier in HPLC analysis of histones to enhance selectivity. It is an effective additive for zinc electrodeposition.
  5. HFBA (0.1%) has been made use of as a mobile phase in the HPLC/LC-MS protocol for the detection of aquatic planktonic microbial side cells. LC/ESI-MS has been published to explore the impacts of numerous acids, consisting of HFBA, on the reverse phase separation of intact proteins. A modified version of the peptide ladder sequencing method making up allyl isothiocyanate and HFBA has been reported.
  6. Heptafluorobutyric acid is an ion pair reagent made use of backwards stage HPLC. It is utilized for the sequencing, synthesis, as well as dissolution of healthy proteins and also peptides. It is used as a mobile phase modifier in HPLC evaluation of histones to enhance selectivity. It is a reliable additive for zinc electrodeposition.
    Perfluorobutyric acid is made use of as a mobile phase modifier to improve the selectivity of histone HPLC analysis. It is used as an ion pair reagent in the prep work and evaluation of underivated peptides by retention stage HPLC.
  7. Perfluorobutyric acid and its by-products are a class of chemical intermediates that can be used as intermediates for new sorts of drugs, gunpowder, and also flavors, along with as resources or additives for the synthesis of brand-new natural polymer products. At the same time, they can likewise be utilized as organic solvents themselves.

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This is William, CEO of Zhishang Chemical Co., Ltd.

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Application of Heptafluorobutyric Acid

CN201610462283.0 discloses a kind of all-organic multiple fluorinated epoxy superhydrophobic composite coating and its preparation method and application method. The coating includes a coating system and a curing agent, wherein the components of the coating system include epoxy resin, polytetrafluoroethylene Particles, polyperfluoromethyl isopropyl ether and organic solvent, the curing agent is made by reacting diethylenetriamine and perfluorobutyric acid. The preparation method includes the preparation of the coating system and the preparation of the curing agent. Its use method is to dissolve the curing agent in the diluent, add the obtained curing agent solution into the coating system, mix it evenly, and apply it on the desired surface for curing. The all-organic multiple fluorinated epoxy superhydrophobic composite coating of the present invention has the advantages of good superhydrophobic performance, good wear resistance, water impact resistance, corrosion resistance, strong adhesion, wide application range, etc., and the preparation method is simple and easy implementation, suitable for large area use.

Preparation of Heptafluorobutyric Acid

In the electrolytic fluorination tank, 600 kg of n-butyryl fluoride and anhydrous hydrogen fluoride electrolytic liquid, the mass concentration of n-butyryl fluoride is 40%, and the electrolytic fluorination reaction is carried out under the following conditions, the electrolysis temperature is 10 ° C, and the voltage and current are respectively 7V and 2000A, current density 0.03A/cm2, reflux condensation temperature -45°C. Perfluorobutyryl fluoride accounted for 31% by weight of the mixed gas generated during the electrolysis process, entrained hydrogen fluoride accounted for 20% by weight, and other gases accounted for 49%. As the electrolysis proceeds, the electrolyte should be regularly replenished in the electrolytic cell, but the concentration of the electrolyte should be adjusted according to the current and voltage, and the adjustment range is between 23% and 45%.

Pass the electrolysis mixed gas into the reactor of n-butyric acid and n-butyric anhydride (molar ratio 1:4), and rectify the absorption liquid to obtain 12.3 kg of perfluorobutyric acid every 24 hours, with a content of 99% and a water content of 350PPm , The fluoride ion content is less than 40PPm. The yield of this process reaches 48%.

Reference

  1. Perfluorobutanoic acid – WikiPedia
  2. CN201610462283.0 All-organic multiple fluorinated epoxy superhydrophobic composite coating and its preparation method and application method

Heptafluorobutyric Acid Supplier and Manufacturer

As a heptafluorobutyric supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best heptafluorobutyric raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for heptafluorobutyric and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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