Ethyl Methanesulfonate CAS 62-50-0

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  • Appearance: Colorless liquid
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Ethyl Methanesulfonate Supplier & Manufacturer

Basic Info

What is Ethyl Methanesulfonate?

Ethyl methanesulfonate (EMS) is a mutagenic, teratogenic, as well as cancer causing organic substance with the molecular formula C3H8SO3. It produces arbitrary mutations in hereditary product through nucleotide alternative; Particularly the G: C to A: T shift caused by guanine alkylation. EMS generally just creates point mutation. As a result of its strength and well-known anomaly range, EMS is the most generally utilized chemical mutagen genetics in experiments. After that anomalies brought on by EMS direct exposure can be studied in genetic screening or various other evaluations.

Ethyl methanesulfonate is a DNA ethylating agent with mutagenicity to pets and plants, and carcinogenicity to creatures. It has actually been used as a model alkylating agent in the research study of DNA repair service processes. EMS generates guanine cytosine (G/C) base alternative to adenine thymine (A/T). EMS likewise generates factor anomaly as well as solitary nucleotide polymorphisms in the genome. EMS is a potential chemical mutagen used to induce anomalies in rice, wheat and Arabidopsis.

Ethyl Methanesulfonate Uses

  1. Ethyl methanesulfonate is made use of as a mutagen in mammalian and plant cells. It is utilized as a model alkylating agent in the study of deoxyribonucleic acid (DNA) fixing procedures.
  2. Used as a research device for mutagenic and cancer causing research. It is taken into consideration a possible human male contraceptive pill. It is also thought about a relatively easy to fix male hemostatic for insect and also mammalian bugs.
  3. Ethyl methanesulfonate alkylation nucleophilic reagents, such as hydroxyl, amino, and thiol groups in models and biomaterials. Hydrolyzed by excessive alkaline water solution into non corrosive and non-toxic products. Hydrolyze into highly corrosive products when exposed to water.

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Application in Biological Research

EMS can induce mutations at a rate of 5×10-4 to 5×10-2 per gene without causing substantial damage. The mutation rate of each gene 5×10-4 observed in the typical EMS mutation experiment of the model organism Caenorhabditis elegans corresponds to the original mutation rate of about 7×10-6 mutations for each G/C base pair, or about 250 mutant gametes (including about 100 Mbp, 36% GC haploid genome) initially induced. Such mutagenic gametes will have approximately 9 different functional loss gene mutations, of which 1 to 2 mutations are located within essential genes and are therefore fatal. However, since the same essential genes are unlikely to mutate in independent gametes, and if the loss of essential genes does not kill the gamete itself, downstream gamete fusion typically allows the resulting zygote and organism to survive, as currently heterozygous non functional mutant alleles may be rescued by wild-type alleles provided by another gamete.


  1.  “Ethyl Methanesulfonate” (PDF)Report on Carcinogens, Fourteenth Edition. NIEHS.
  2. Yost HT Jr, Chaleff RS, Finerty JP. Induction of mitotic recombination in Saccharomyces cerevisiae by ethyl methane sulphonate. Nature. 

Ethyl Methanesulfonate Supplier and Manufacturer

As a ethyl methanesulfonate supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best ethyl methanesulfonate raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for ethyl methanesulfonate and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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