Ethoxylated Hydrogenated Castor Oil CAS 61788-85-0

1. Naproxen controlled-release tablets
   Immediate release granules secret formula: naproxen 300mg, whey protein 880mg, PVP 18mg, tapioca starch 30mg, sodium carboxymethyl tapioca starch 18mg, magnesium stearate 1.2mg;
   Controlled release granules recipe: naproxen 450mg, hydrogenated castor oil 171mg, ethyl cellulose 54mg;
   The above two kinds of granules are stirred, and the candy is prepared by tableting.

2. High-efficiency potassium chloride tablets
   Take the prescription amount of potassium chloride crystals and float in the molten cetyl alcohol, hydrogenated castor oil and polyether, and make particles according to a 20-mesh sieve when mixing until it is close to coagulation. grain. After the indoor temperature is dry, add a lubricating hydraulic core, and finally get the sugar coating.
3. N-(a hydroxyethyl) nicotine nitrate frame sheet
   Take 90 g of hydrogenated castor oil, disperse it into particles with a diameter of 1.5 μm with a micropowder mill, and immediately mix it with 8 g of hydroxypropyl methylcellulose. The compound is granulated by mixing 20 g of 10% hydroxypropyl methyl cellulose and 43 g of water at 50°C. Dry and prepare granules A; take 2.5 g of compound A, add 7.5 g of the main drug to make granules B; take 5.9 g of whey protein, 3 g of microcrystalline cellulose, 0.1 g of magnesium stearate and 1 g of the main drug and mix Make granules C; mix granules A, B, and C into tablet candies.
4. Raw material of retarding film coating layer
   Special drugs need to achieve the actual effect of retardation according to the film coating layer. Hydrogenated castor oil is one of the common retardation raw materials, and the general use amount is 5.0%-20.0% of the total weight of the coating layer.

Hydrogenated castor oil can be used as a sheet-like lubricant. Although its moisturizing effect is not as good as that of magnesium stearate, hydrogenated castor oil is the best choice for very few sheets that cause stickiness during the whole process of tableting candies. For example, clopidogrel hydrogen sulfate tablets need to use hydrogenated castor oil as a lubricant.

Specifically, most of the drugs with strong optical activity (strong water absorption) and drugs that are very likely to cause spots in the whole process of tableting candy can use hydrogenated castor oil as a lubricating fluid, which can not only have a moisturizing effect, but also It can prevent the effect of sticking and flushing, and also has the effect of hydrophobicity, which is not easy to cause spots.

Hydrogenated castor oil is generally used as a lubricant, and the amount used is generally 0.2%-2%.

Various vegetable oils such as castor oil, salad oil, edible oil and its camellia oil are often used as organic solvents or oil-phase cultivation substrates in the pharmaceutical preparation profession, but the long-term reliability of the pharmaceutical preparation profession is affected by the easy air oxidation and deterioration of edible oils. , according to the problem that edible oil is easy to be oxidized and deteriorated by air, it is found that after the edible oil is esterified, the commodity is not easy to be oxidized and deteriorated by air, and its vegetable oil characteristics do not change significantly.

Therefore, in the types of creams and suppositories, hydrogenated castor oil can be used for edible oil or liquid paraffin, because hydrogenated castor oil is a crystalline solid, and the consistency of the mortar after melting is very large, which can greatly reduce vegetable oils or fats. The amount of oil phase used, and the paste is smoother and more delicate.