Estriol CAS 50-27-1
Factory Supply Estriol CAS 50-27-1 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Estriol Supplier & Manufacturer
Estriol: The Complete Guide
Estriol for Sale
|Pharmaceutical raw materials; Daily chemicals; Pharmaceutical intermediates
What is Estriol?
Estriol is a metabolite of estradiol in the body and is a natural estrogen mainly found in urine. However, abuse of antibiotics and hormones often exists in the aquaculture industry, resulting in a certain amount of estriol hormone remaining in animal-derived foods, which may cause human hormone-related diseases to easily occur after eating, such as breast, ovary, prostate tumors, Endocrine-related tumors, birth defects and birth defects, etc., will also have a serious impact on the growth and development of infants and adolescents.
Estriol (E3) belongs to 18-carbon steroid hormones and is a metabolite of estrone and estradiol (E2). It is mainly synthesized by the fetus-placenta and enters the maternal blood through the placenta. In normal pregnancy, E3 increases continuously with the increase of gestational age, and plays an important role in regulating fetal development and uterine muscle movement. Because 90% of E3 is excreted from the urine through the kidneys, unconjugated estriol (uE3) is not excreted through the kidneys of pregnant women, which is less disturbed and can more accurately reflect changes in fetal placental function. Reflect the growth and development of the fetus.
- Elevation of uE3 can be seen in fetal adrenal cortex activity enhancement, macrosomia, twins or multiple births, maternal heart disease and liver cirrhosis can also cause E3 elevation.
- Decreased uE3 can be seen in fetal death, anencephaly, placental steroid sulfatase deficiency, placental aromatase deficiency, fetal adrenal history-Len-Auer syndrome (a disorder of cholesterol biosynthesis, SLOS), lipoid adrenal cortex Hyperplasia (LAH), adrenocorticotropic hormone (ACTH) deficiency and ACTH insensitivity syndrome, etc., in addition to maternal intake of steroid food or drugs can also cause decreased.
- It works for leukopenia triggered by radiation treatment or radiotherapy, and also can also reduce the leaks in the structure and also fragility of capillary, as well as can be utilized for the treatment of numerous hemorrhages. It can promptly stop bleeding after menorrhagia, tonsillectomy or hysterectomy. It likewise has a particular result on prostate hypertrophy and prostate cancer.
- Estrogen drugs. For leukopenia, various menstrual illness, senescent vaginitis, ladies’s climacteric disorder, etc. There might be short-term bust swelling as well as lumps, as well as menstruation conditions, which can recuperate on their own about 1 month after quiting the medicine. Clients with breast hyperplasia, breast swellings, lumps that may be associated with women hormonal agents, aplastic anemia as well as liver illness must not utilize it.
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What are the Types of Estrogen?
Estrogen is primarily divided right into 3 kinds:
- Estrogen (E1): Individuals create this type of estrogen after menopause.
- Estradiol (E2): This is the most usual type of estrogen created by individuals.
- Estriol (E3): This is the main sort of estrogen in the blood of expectant women.
Clinical Significance of Estradiol and Estriol
- Physiological increase: For pregnant women, the placenta can secrete a large amount of estrogen.
- Pathological increase: Increased estrogen often causes female precocious puberty and irregular menstruation.
- Hypothalamic-pituitary hyperfunction: the secretion of gonadotropins increases, thereby promoting the increase of ovarian estrogen secretion. Such as pituitary tumors, brain tissue hyperplasia and so on.
- Hyperfunction of the ovaries: Causes increased secretion of estrogen, such as ovarian tumors.
- Tissues other than the pituitary gland secrete heterologous gonadotropins: lead to increased secretion of estrogen, such as lung cancer, thymus cancer and other cancerous tissues.
- Non-specific increase: For example, in hyperthyroidism and cirrhosis, the sex hormone binding protein increases, which often leads to an increase in the total estrogen content. In recent years, it is common to take too many health products and beverages containing sex hormones, which can also cause an increase in serum estrogen.
- Pathological reduction: Estrogen reduction often causes female sexual infantilism, delayed puberty, and secondary amenorrhea.
- Hypothalamic-pituitary hypofunction: decreased secretion of gonadotropins leads to decreased estrogen secretion from the ovaries, such as intracranial tumor compression, pituitary atrophy, and brain tissue ischemia.
- Hypofunction of the ovaries: Causes decreased estrogen secretion, such as congenital ovarian hypoplasia, ovariectomy, sex hormone synthase deficiency, etc.
- Non-specific reduction: For example, in hypothyroidism and severe malnutrition, the sex hormone binding protein decreases, which often leads to a decrease in the total estrogen content.
Estriol Supplier and Manufacturer
As a estriol supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best estriol raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for estriol and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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