Esmolol Hydrochloride CAS 81161-17-3
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Esmolol Hydrochloride Suppiler
Esmolol Hydrochloride: The Complete Guide
Esmolol Hydrochloride for Sale
Basic Info of Esmolol Hydrochloride
Esmolol Hydrochloride CAS 81161-17-3
Pharmaceuticals, pesticides, dye intermediates; Daily chemicals; Pharmaceutical raw materials
What is Esmolol Hydrochloride?
Esmolol is an ultra brief acting heart Selective P receptor blocker with no innate supportive task. The capability of fast turnaround makes esmolol especially appropriate for the acute monitoring of supraventricular tachycardia and the control of high blood pressure and also heart rate in surgical procedure or various other cardiac emergency situations.
Esmolol hydrochloride HCl, chemical name (±)-3-4-[2-hydroxy-3-(1-methylethylamino) propoxy] phenyl propionate methyl ester hydrochloride, is a type of aryloxypropylamine with ultra short-term selectivity β 1 receptor blockers, which are primarily prevented by competition for catecholamine binding websites β 1 receptor chemialbook, which can reduce resting and also exercise heart price, lower high blood pressure as well as myocardial oxygen consumption. At the same time, it has the characteristics of quick start, high bioavailability, brief half-life, precise efficiency and reduced side effects. Presently, it is mainly utilized in the therapy of supraventricular arrhythmias and also severe myocardial anemia, and additionally has evident effects on acute myocardial infarction, unpredictable angina pectoris, postoperative hypertension and various other conditions.
Esmolol Hydrochloride Uses
- Antiarrhythmic drugs; Cardiac selectivity β1 receptor blocker; Cardiac selective – adrenergic blocker. Antiarrhythmic arrhythmia.
- Esmolol hydrochloride is suitable for paroxysmal supraventricular tachycardia, which can quickly control the ventricular rate of patients with atrial fibrillation or atrial flutter during perioperative period, postoperative period or other emergencies requiring short-term control of ventricular rate with short-term drugs. Esmolol hydrochloride is also applicable to non compensated sinus tachycardia. According to the doctor’s judgment, rapid heart rate requires special intervention. Esmolol hydrochloride is not suitable for chronic environments where transfer to another drug is expected.
- Esmolol hydrochloride. A cardiac selective and short acting β1 receptor blocker, which takes effect rapidly but lacks intrinsic sympathetic and membrane stabilizing properties, is used to treat supraventricular arrhythmia and control hypertension and tachycardia during surgery.
- Esmolol hydrochloride is mainly used for the treatment of supraventricular arrhythmia and acute myocardial ischemia. It has obvious effects on acute myocardial infarction, unstable angina pectoris, postoperative hypertension and other diseases.
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Application of Esmolol Hydrochloride
Esmolol hydrochloride is a β 1 careful (heart careful) adrenergic receptor blocker, with fast onset and extremely short duration of action, has no considerable innate sympathetic or membrane layer stabilizing activity at the restorative dosage. The elimination half-life is about 9 minutes after intravenous mixture. Esmolol hydrochloride hinders the β 1 receptor, yet this preferential result is not absolute. At greater dosages, it begins to inhibit the β 2 receptors.
Esmolol hydrochloride is rapidly metabolized with the hydrolysis of ester bonds, primarily with esterases in the cytosol of erythrocytes, yet not through plasma cholinesterase or erythrocyte membrane acetylcholinesterase. The total clearance price of body has to do with 20 L/ kg/ HR, which is larger than the cardiac output; For that reason, the metabolic rate of esmolol hydrochloride is not restricted by the speed of blood circulation to metabolic tissues (such as liver), neither is it affected by liver or kidney blood circulation. The quick circulation half-life of esmolol hydrochloride has to do with 2 minutes, as well as the elimination half-life is about 9 mins.
Preparation of Esmolol Hydrochloride
An option of 17 g (0.1 mol) of 3 – (4-hydroxyphenyl) propionic acid in 500 ml of methanol as well as 2 ml of focused sulfuric acid was put in a Soxhlet extractor furnished with 3A molecular screen. The solution was refluxed for 72 hrs, and the filter was changed every 24 hr. The response medium was then vaporized to an oil, dissolved in 100 ml of toluene and extracted with 100 ml of water (3 times). The toluene stage was dried over magnesium sulfate, treated with turned on carbon and vaporized to acquire 15 g (80%) of a transparent oil. The NMR spectrum follows that of methyl 3 – (4-hydroxyphenyl) propionate.
The above oil is directly made use of for condensation response with epichlorohydrin. A blend of 0.1 mol of methyl 3 – (4-hydroxyphenyl) propionate, 0.2 mol of potassium carbonate as well as 0.4 mol of epichlorohydrin in 250 ml of acetone was heated at reflux for 24 hr. And then the response tool was filteringed system and evaporated. The deposit was dissolved in 100 ml of toluene as well as washed with 100 ml of 1.0 n NaOH as well as 100 ml of water (2 times). The toluene stage was then dried out over magnesium sulfate as well as evaporated to provide unrefined item as oil. Cleansed by vacuum cleaner distillation (156. degree. C./ 0.4 mm) as well as given methyl 3 – [4 – (2,3-epoxypropoxy) phenyl] propionate. NMR as well as IR ranges as well as essential analysis information followed the specified framework.
A mixture of 50 g (0.21 mol) of methyl 3 – [4 – (2,3-epoxypropoxy) phenyl] propionate and 100 ml of isopropylamine in 100 ml of methanol was heated at reflux for 4 hours. The reaction medium was after that evaporated, the resulting oil was soaked up in methanol and also treated with diethyl ether HCl and also crystals were offered, which were recrystallized in a similar way to provide 28 g (47%) of white crystals: melting point 85-86 ° C. NMR, IR ranges as well as important analysis information are consistent with the structure of methyl 4 – (2-hydroxy-3 – ((1-methylethyl) amino) propoxy) benzoate.
In practice, it is typically made use of in the form of hydrochloride.