Esmolol Hydrochloride CAS 81161-17-3
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Factory Supply Esmolol Hydrochloride CAS 81161-17-3 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Esmolol Hydrochloride Supplier & Manufacturer
Esmolol Hydrochloride: The Complete Guide
- Item 1: Basic Info of Esmolol Hydrochloride
- Item 2: What is Esmolol Hydrochloride?
- Item 3: Esmolol Hydrochloride Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Esmolol Hydrochloride
- Item 6: Preparation of Esmolol Hydrochloride
- Item 7: Quality Control of Esmolol Hydrochloride
- Item 8: Hot Sale Products
- Item 9: Get Esmolol Hydrochloride Quotation
Esmolol Hydrochloride for Sale
Basic Info of Esmolol Hydrochloride
Basic Info
Chemical Properties
Other Info
Basic Info
Chemical Name: | Esmolol Hydrochloride |
Other Name: | Esmolol Hydrochloride CAS 81161-17-3 |
CAS: | 81161-17-3 |
EINECS: | 636-017-0 |
Type: | Pharmaceuticals, pesticides, dye intermediates; Daily chemicals; Pharmaceutical raw materials |
Molecular Formula: | C16H26ClNO4 |
Molecular Weight: | 331.83 |
Chemical Properties
Melting point | 48-50°C |
density | 1.026 |
storage temp. | −20°C |
solubility | H2O: soluble12mg/mL |
form | buffered aqueous solution |
color | White to Off-White |
Water Solubility | Slightly soluble |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Esmolol Hydrochloride MSDS; Esmolol Hydrochloride COA |
What is Esmolol Hydrochloride?
Esmolol is an ultra brief acting heart Selective P receptor blocker with no innate supportive task. The capability of fast turnaround makes esmolol especially appropriate for the acute monitoring of supraventricular tachycardia and the control of high blood pressure and also heart rate in surgical procedure or various other cardiac emergency situations.
Esmolol hydrochloride HCl, chemical name (±)-3-4-[2-hydroxy-3-(1-methylethylamino) propoxy] phenyl propionate methyl ester hydrochloride, is a type of aryloxypropylamine with ultra short-term selectivity β 1 receptor blockers, which are primarily prevented by competition for catecholamine binding websites β 1 receptor chemialbook, which can reduce resting and also exercise heart price, lower high blood pressure as well as myocardial oxygen consumption. At the same time, it has the characteristics of quick start, high bioavailability, brief half-life, precise efficiency and reduced side effects. Presently, it is mainly utilized in the therapy of supraventricular arrhythmias and also severe myocardial anemia, and additionally has evident effects on acute myocardial infarction, unpredictable angina pectoris, postoperative hypertension and various other conditions.
Esmolol Hydrochloride Uses
- Antiarrhythmic drugs; Cardiac selectivity β1 receptor blocker; Cardiac selective – adrenergic blocker. Antiarrhythmic arrhythmia.
- Esmolol hydrochloride is suitable for paroxysmal supraventricular tachycardia, which can quickly control the ventricular rate of patients with atrial fibrillation or atrial flutter during perioperative period, postoperative period or other emergencies requiring short-term control of ventricular rate with short-term drugs. Esmolol hydrochloride is also applicable to non compensated sinus tachycardia. According to the doctor’s judgment, rapid heart rate requires special intervention. Esmolol hydrochloride is not suitable for chronic environments where transfer to another drug is expected.
- Esmolol hydrochloride. A cardiac selective and short acting β1 receptor blocker, which takes effect rapidly but lacks intrinsic sympathetic and membrane stabilizing properties, is used to treat supraventricular arrhythmia and control hypertension and tachycardia during surgery.
- Esmolol hydrochloride is mainly used for the treatment of supraventricular arrhythmia and acute myocardial ischemia. It has obvious effects on acute myocardial infarction, unstable angina pectoris, postoperative hypertension and other diseases.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Application of Esmolol Hydrochloride
Esmolol hydrochloride is a β 1 careful (heart careful) adrenergic receptor blocker, with fast onset and extremely short duration of action, has no considerable innate sympathetic or membrane layer stabilizing activity at the restorative dosage. The elimination half-life is about 9 minutes after intravenous mixture. Esmolol hydrochloride hinders the β 1 receptor, yet this preferential result is not absolute. At greater dosages, it begins to inhibit the β 2 receptors.
Esmolol hydrochloride is rapidly metabolized with the hydrolysis of ester bonds, primarily with esterases in the cytosol of erythrocytes, yet not through plasma cholinesterase or erythrocyte membrane acetylcholinesterase. The total clearance price of body has to do with 20 L/ kg/ HR, which is larger than the cardiac output; For that reason, the metabolic rate of esmolol hydrochloride is not restricted by the speed of blood circulation to metabolic tissues (such as liver), neither is it affected by liver or kidney blood circulation. The quick circulation half-life of esmolol hydrochloride has to do with 2 minutes, as well as the elimination half-life is about 9 mins.
Preparation of Esmolol Hydrochloride
An option of 17 g (0.1 mol) of 3 – (4-hydroxyphenyl) propionic acid in 500 ml of methanol as well as 2 ml of focused sulfuric acid was put in a Soxhlet extractor furnished with 3A molecular screen. The solution was refluxed for 72 hrs, and the filter was changed every 24 hr. The response medium was then vaporized to an oil, dissolved in 100 ml of toluene and extracted with 100 ml of water (3 times). The toluene stage was dried over magnesium sulfate, treated with turned on carbon and vaporized to acquire 15 g (80%) of a transparent oil. The NMR spectrum follows that of methyl 3 – (4-hydroxyphenyl) propionate.
The above oil is directly made use of for condensation response with epichlorohydrin. A blend of 0.1 mol of methyl 3 – (4-hydroxyphenyl) propionate, 0.2 mol of potassium carbonate as well as 0.4 mol of epichlorohydrin in 250 ml of acetone was heated at reflux for 24 hr. And then the response tool was filteringed system and evaporated. The deposit was dissolved in 100 ml of toluene as well as washed with 100 ml of 1.0 n NaOH as well as 100 ml of water (2 times). The toluene stage was then dried out over magnesium sulfate as well as evaporated to provide unrefined item as oil. Cleansed by vacuum cleaner distillation (156. degree. C./ 0.4 mm) as well as given methyl 3 – [4 – (2,3-epoxypropoxy) phenyl] propionate. NMR as well as IR ranges as well as essential analysis information followed the specified framework.
A mixture of 50 g (0.21 mol) of methyl 3 – [4 – (2,3-epoxypropoxy) phenyl] propionate and 100 ml of isopropylamine in 100 ml of methanol was heated at reflux for 4 hours. The reaction medium was after that evaporated, the resulting oil was soaked up in methanol and also treated with diethyl ether HCl and also crystals were offered, which were recrystallized in a similar way to provide 28 g (47%) of white crystals: melting point 85-86 ° C. NMR, IR ranges as well as important analysis information are consistent with the structure of methyl 4 – (2-hydroxy-3 – ((1-methylethyl) amino) propoxy) benzoate.
In practice, it is typically made use of in the form of hydrochloride.
Reference
Esmolol hydrochloride – PubChem
Esmolol Hydrochloride Supplier and Manufacturer
As a esmolol hydrochloride supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best esmolol hydrochloride raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for esmolol hydrochloride and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Service
FAQ
Shipping
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Esmolol Hydrochloride
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