Esmolol Hydrochloride CAS 81161-17-3

An option of 17 g (0.1 mol) of 3 – (4-hydroxyphenyl) propionic acid in 500 ml of methanol as well as 2 ml of focused sulfuric acid was put in a Soxhlet extractor furnished with 3A molecular screen. The solution was refluxed for 72 hrs, and the filter was changed every 24 hr. The response medium was then vaporized to an oil, dissolved in 100 ml of toluene and extracted with 100 ml of water (3 times). The toluene stage was dried over magnesium sulfate, treated with turned on carbon and vaporized to acquire 15 g (80%) of a transparent oil. The NMR spectrum follows that of methyl 3 – (4-hydroxyphenyl) propionate.

The above oil is directly made use of for condensation response with epichlorohydrin. A blend of 0.1 mol of methyl 3 – (4-hydroxyphenyl) propionate, 0.2 mol of potassium carbonate as well as 0.4 mol of epichlorohydrin in 250 ml of acetone was heated at reflux for 24 hr. And then the response tool was filteringed system and evaporated. The deposit was dissolved in 100 ml of toluene as well as washed with 100 ml of 1.0 n NaOH as well as 100 ml of water (2 times). The toluene stage was then dried out over magnesium sulfate as well as evaporated to provide unrefined item as oil. Cleansed by vacuum cleaner distillation (156. degree. C./ 0.4 mm) as well as given methyl 3 – [4 – (2,3-epoxypropoxy) phenyl] propionate. NMR as well as IR ranges as well as essential analysis information followed the specified framework.

A mixture of 50 g (0.21 mol) of methyl 3 – [4 – (2,3-epoxypropoxy) phenyl] propionate and 100 ml of isopropylamine in 100 ml of methanol was heated at reflux for 4 hours. The reaction medium was after that evaporated, the resulting oil was soaked up in methanol and also treated with diethyl ether HCl and also crystals were offered, which were recrystallized in a similar way to provide 28 g (47%) of white crystals: melting point 85-86 ° C. NMR, IR ranges as well as important analysis information are consistent with the structure of methyl 4 – (2-hydroxy-3 – ((1-methylethyl) amino) propoxy) benzoate.

In practice, it is typically made use of in the form of hydrochloride.