Empagliflozin CAS 864070-44-0
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Empagliflozin Supplement
Empagliflozin: The Complete Guide
Index of Empagliflozin Contents
Empagliflozin for Sale
Basic Info of Empagliflozin
What is Empagliflozin?
Empagliflozin, the trade name is “Jardiance”, the Chinese trade name is “Ou Tangjing” (Mainland), “Enpaitang” (Taiwan, China) or “Shitangda” (Hong Kong, China), which are brand-new The first-generation SGLT2 inhibitor (kind II sodium-glucose transporter prevention) was accepted by the united state Fda (FDA) in August 2014, and also was approved for advertising in landmass China in September 2017. In combination with diet regimen control and exercise, it is used to deal with type 2 diabetes in adults.
Empagliflozin, a kind 2 sodium sugar cotransporter (SGLT-2, sodium-dependent glucose cotransporter2) inhibitor collectively established by Boehringer Ingelheim and also Eli Lilly. SGLT-2 inhibitor is a new kind of hypoglycemic medication, mainly by inhibiting the expression of SGLT-2, reducing the kidney reabsorption of glucose, enhancing the discharging of sugar in the urine, therefore lowering the degree of plasma glucose, as well as its hypoglycemic result is independent of in beta cell feature as well as insulin resistance.
Empagliflozin decreases the capacity of the kidneys to reuse glucose right into the blood stream and also excrete it in the pee, assisting to considerably minimize blood sugar level degrees, threat of kidney and heart disease, obese and also blood pressure in individuals. Various from various other dental drugs currently utilized for the therapy of kind 2 diabetes, empagliflozin is the very first SGLT2 hypoglycemic medication to complete the cardiovascular prognosis research, as well as it is the only oral hypoglycemic drug that Four-fold effect of protecting the heart, safeguarding the kidney and weight loss.
- Individuals with kind 2 diabetes continue to have high blood sugar degrees since their SGLT2 is also energetic. “Engliqing” can decrease the capacity of the kidney to recover glucose right into the blood, and make the sugar excreted out of the body via the pee.
- Restraint of SGLT2 can decrease the amount of sugar reabsorbed right into the blood by proximal kidney tubules, and boost urinary system glucose discharging, warmth loss as well as osmotic diuresis. Therefore, restraint of SGLT2 can considerably boost blood sugar, body weight and high blood pressure.
- Empagliflozin is made use of to improve glycemic control in grownups with type 2 diabetes that have not accomplished ample glycemic control with diet and also workout. It should not be utilized to deal with clients with type 1 diabetes mellitus, people with raised blood or pee ketones (diabetic person ketoacidosis), individuals with severe renal problems, end-stage kidney condition, as well as individuals on dialysis.
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The Efficacy of Empagliflozin
Sugar control effect
By inhibiting SGLT2 protein in renal tubules, “engliqing” can block the recovery of sugar by the kidney, and the excess sugar will be excreted out of the body through urine, thus helping to manage blood glucose. Therefore, “engliqing” can significantly improve the blood glucose level and make the glycated heme (HbA1c) index reach an ideal level without insulin dependence.
- Efficacy in reducing cardiovascular and mortality risk
Different from the oral drugs currently used for the treatment of type 2 diabetes, “engliqing” has become the only oral hypoglycemic drug that has been proved to reduce cardiovascular risk in cardiovascular prognosis research.
According to large international research empa-reg output ® The results showed that in adult patients with type 2 diabetes with high risk of cardiovascular events, the addition of “englitazone” could significantly reduce the cardiovascular risk on the basis of standard treatment. Thus, “engliqing” has become the only oral hypoglycemic drug that has been proved to reduce cardiovascular risk in cardiovascular prognosis research.
- Diabetic heart
The average life expectancy of type 2 diabetes patients with high risk of cardiovascular events is shortened by 12 years, and nearly 50% of the death events of type 2 diabetes patients are caused by cardiovascular diseases. In fact, cardiovascular disease has always been the number one killer of patients with type 2 diabetes. This study confirmed that “engliqing” prevented one-third of cardiovascular death events, and it is the only hypoglycemic drug that can reduce cardiovascular risk and cardiovascular death at the same time in cardiovascular prognosis research.
- Efficacy in reducing the risk of kidney disease
In the aspect of kidney health “diabetic kidney”, studies have confirmed that “englitazone” can significantly reduce.
- Diabetic kidney
Diabetes patients have a much higher chance of suffering from kidney disease than non diabetes people, about half of which are affected by type 2 diabetes. In the late stage, kidney disease is more likely to lead to renal failure, and patients must receive dialysis treatment or kidney transplantation. In addition to being associated with a shorter than average life span, decreased renal function also increases the risk of other diabetes related complications, such as hypoglycemia and cardiovascular disease.
- Managing overweight outcomes
Studies have confirmed that “englitazone” can reduce the average weight of 2 to 3 kg and the waist circumference of 2 cm for patients with diabetes.