DMSO Dimethyl Sulfoxide Liquid CAS 67-68-5

Methane mercaptan reacts with dimethyl sulfoxide and catalyst under the conditions of corresponding temperature and pressure to generate dimethyl disulfide.

Its chemical reaction mechanism is as follows: 2CH3SH+(CH3)2SO=(CH3)2S+(CH3)2S2+H2O Methane mercaptan and dimethyl sulfoxide are fed into the reactor at a molar ratio of 2:0.95, and in the presence of an alumina catalyst Carry out the synthesis reaction, the reaction temperature is 250 ° C, the reaction pressure is 0.3 MPa, and the reaction products are dimethyl disulfide, dimethyl sulfide, and water. After the reaction product is condensed and cooled, it is left to stand for separation, and the crude product dimethyl dimethyl sulfide is obtained by separation. Sulfur, and then rectified to obtain qualified dimethyl disulfide finished product.

At a temperature of 60°C and a pressure of 0.5MPa, using ozone (15% by volume, the rest is oxygen) as the oxidant, dimethyl sulfoxide, ozone and solvent acetone were reacted in a molar ratio of 1:1:1 . The results of the reaction for 2 hours are as follows: the conversion rate of dimethyl sulfoxide is 74%; the effective utilization rate of ozone is 76%; the selectivity of dimethyl sulfone is 99%.

As an excellent solvent, dimethyl sulfoxide is widely used in petroleum, chemical industry, medicine, electronics, synthetic fiber, plastic, printing and dyeing and other industries, especially with the new quinolone antibiotics such as norfloxacin and forloxacin in the pharmaceutical industry With the development of the production of drugs and intermediates such as fluorochloroaniline, the demand for DM-SO is increasing year by year.

As a reaction solvent, dimethyl sulfoxide is widely used in the synthesis of pharmaceuticals and pharmaceutical intermediates. For example, 3,4-dichloronitrobenzene reacts with potassium fluoride in dimethyl sulfoxide to obtain fluorochloroaniline, the intermediate is the synthesis of the third generation quinolone antibacterial drug – norfloxacin (norfloxacin) , an important raw material of ciprofloxacin. Dimethyl sulfoxide is also used in the synthesis of 2,3,4,-trifluoronitrobenzene, and this intermediate can be used in the synthesis of third-generation quinolone antibacterial drugs—ofloxacin (ofloxacin), fluorine Synthesis of rofloxacin (dofloxacin), lomefloxacin hydrochloride and rufloxacin hydrochloride.

In addition, dimethyl sulfoxide has been used in the synthesis of levamisole hydroxy acid inositol ester, levamisole phosphate, berberine, sucrose fatty acid polyester and the extraction and production of traditional Chinese medicine. Dimethyl sulfoxide itself has anti-inflammatory, analgesic, promoting blood circulation and wound healing effects, and has diuretic and sedative effects, which can increase drug absorption and improve efficacy. At present, it has been widely used in external medicines such as Guyouling, athlete’s foot medicine, and Fuhydropine ointment produced in my country and in external preparations in major hospitals.

At present, dimethyl sulfoxide in my country is mainly used in the synthesis of pharmaceutical intermediates fluorochloroaniline and 2,3,4,-trifluoronitrobenzene in the pharmaceutical industry. In addition, a certain amount of drug synthesis, extraction of traditional Chinese medicines, and external medicines and ointments are also consumed. Dimethyl sulfoxide. Norfloxacin, ciprofloxacin and forloxacin are a new generation of fluoroquinolone synthetic antibacterial drugs, which have the characteristics of broad-spectrum, high efficiency, less toxic and side effects, and relatively cheap prices. In recent years, domestic production has developed very rapidly. , so the demand for the solvent dimethyl sulfoxide is also growing.

Dimethyl sulfoxide solvent is also consumed in the synthesis of ofloxacin, dofloxacin and intermediate – 2,3,4,-trifluoronitrobenzene; the synthesis of berberine, levamisole, mebendazole and other drugs requires approximately consumption of dimethyl sulfoxide. At present, the total demand for dimethyl sulfoxide in the pharmaceutical industry is about 3,500 tons. It is expected that the demand for dimethyl sulfoxide in the pharmaceutical industry will increase steadily in the future, and the demand in 2005 will reach about 4,500 tons.