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Diphenylacetonitrile CAS 86-29-3

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Diphenylacetonitrile Supplement

Basic Info of Diphenylacetonitrile

What is Diphenylacetonitrile?

Diphenylacetonitrile is a white to velvety or light yellow crystalline powder, which is soluble in ethanol as well as ether. It is acquired from phenylacetonitrile by Bromination as well as condensation. Diphenylacetonitrile is generally made use of as an intermediate in the manufacture of API for respiratory stimulant therapy. For the production of gastric amine, amine pentamine sulfate, diphenoxylate, diphenylacetaldehyde, doxapram, loperamide, methadone and other APIs.

Dehydration of the amide of diphenylacetic acid with phosphorus oxychloride can produce diphenylacetonitrile in high yield. Diphenylacetonitrile undergoes anhydrous condensation reaction with ethyl 4-bromobutyrate. Subsequent hydrolysis in alkaline medium was used for the quantitative determination of 3-cyano-3,3-diphenylpropionic acid.

Ingestion, intraperitoneal and intravenous routes of poisoning. The subcutaneous route is moderately toxic. Suspected carcinogen with experimental carcinogenicity and tumorigenicity data. When heated up and also decomposed, it will certainly launch harmful NOx as well as CN smoke. See likewise nitrile.

Diphenylacetonitrile Uses

  1. Diphenylacetonitrile can be made use of as a herbicide, utilized for lawn control of young turfs of turfs prior to appearance.
  2. Diphenylacetonitrile is used to synthesize isocyanates, and also further prepared right into UV layers, PU paints, transparent elastomers and also adhesives, etc. In addition, it is likewise used in the polyamide as well as epoxy material markets.
  3. Diphenylacetonitrile is natural synthesis intermediates. In medication, it is made use of to produce stomach amine, phenethyl piperidine, course Santong and also other medicines.
  4. Methadone (m225865) impurity. It is used to synthesize methadone, antispasmodic drugs and other drugs.
  5. Diphenylacetonitrile reacted with ethyl 4-bromobutyrate in anhydrous condensation. Then hydrolyzed in alkaline medium for quantitative determination of 3-cyano-3,3-diphenylpropionic acid.

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Chemical Synthesis of Diphenylacetonitrile

Add 250ml ethyl acetate into 500ml glass 3 mouth flask, start stirring, include 150g benzyl alcohol, include 80g sodium methoxide, stir at 70 ℃ for 2 hours, reduce to room temperature level, as well as include 120ml phenylacetonitrile. Warm to 110 ℃ as well as distill for 10h.

After the response, cool it to space temperature naturally, include 200ml ethyl acetate and also 200ml water for extraction, and also separate the lower water layer.

The top ethyl acetate layer is cleaned once with water and dried out with anhydrous salt sulfate. Ethyl acetate was eliminated by focus under decreased pressure. After that include a small amount of outright ethanol to the oil to cool the crystallization, as well as the condensation product is dried. The yield was 90% and the pureness was 99.0% (GC).

Reference

  1. Diphenylacetonitrile – ChemicalBook
  2. Diphenylacetonitrile – PubChem

Quality Control of Diphenylacetonitrile

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