Denatonium Benzoate Anhydrous CAS 3734-33-6

Factory Supply Denatonium Benzoate Anhydrous CAS 3734-33-6 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Denatonium Benzoate Anhydrous Supplier & Manufacturer

Basic Info

What is Denatonium Benzoate Anhydrous?

The most common sense of taste in human beings is “sour, sweet, bitter, spicy and salty”, and “bitter” is the most sensitive one in the sense of taste, and many people understand it as an unpleasant or unacceptable feeling. The bitter food in life is mainly bitter gourd and Coptis chinensis. In fact, many substances such as quinine, nicotine, caffeine, cocaine, etc. also have bitter taste. Too bitter taste usually makes people or animals reject this kind of food, so the alkaloids contained in many deadly plants have strong bitter taste. From this point of view, bitter taste undoubtedly plays an important role in protecting life. In order to measure the degree of bitterness, similar to the concepts of acidity, sweetness, and spiciness, people use “bitterness” as a measure. Taking quinine, which is famous for its bitter taste, as the benchmark 1, and taking this as a reference standard, denatonium benzoate (also known as “bitter essence”), an artificial substance with a bitterness of 1,000, is the most bitter compound known so far.

Denatonium Benzodiazem is actually more or less an accidental discovery in the experiment. In 1958, Scottish scientist Macfarlan Smith discovered the substance while studying local anesthetics, and a 10 ppm solution of denatonium benzyl was too bitter for the vast majority of people. Endure, even if the concentration is only 50 ppb (parts per billion, 1 ppm = 1000 ppb), the human taste can perceive bitter taste. Perhaps due to keen business intuition, Smith registered it under the trade name Birex, which was subsequently widely used in industrial alcohol, Antifreeze, animal dispersants, daily chemical products.

Denatonium benzyl is a quaternary ammonium salt composed of a quaternary ammonium salt cation and an inert anion, such as benzoate ion or saccharin anion, in which the structure of the cationic part is particularly similar to that of the local anesthetic Lidocaine . In fact, lidocaine only needs to be alkylated and then anion-exchanged to produce denatonium benzyl. The preparation of lidocaine is also quite easy, using 2, 6-dimethylaniline as the raw material, firstly acylation, and then replacing the halogen with diethylamine.

Denatonium Benzoate Anhydrous Uses

  1. Denatonium Benzoate is the most bitter compound known in the world. If the bitterness of quinine is set as the benchmark 1, the bitterness of this product is 1000, and the concentration of the solution is 10ppm. For most people It is already unbearably bitter, and most of its applications are related to its bitter taste. It is a cheap and efficient substitute for sambarine, picariin, quinine, koji glycoside and naringin.
  2. Denatonium benzoate (THS-839) is the most bitter compound known, commonly used as an aversive (bitter) to prevent inappropriate ingestion, used in denatured alcohol, antifreeze, nail biting prevention, respirator mask fit testing , animal repellent, liquid soap and shampoo.
  3. Denatonium benzoate is often used as an aversive agent to prevent people from accidentally ingesting other toxic but tasteless substances. For example, it is added to denatured alcohol, ethylene glycol or methanol with a taste similar to ordinary alcohol, antifreeze, paint, toilet cleaners, animal repellants, liquid soaps and shampoos, in addition to special nail polishes. In medicine, it is used to avoid the bad habit of biting children’s nails, and to drive away large beasts. The effects on human health of prolonged exposure to this substance are uncertain.

The Manager has Something to Say


This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Contact Us
  • Email:
  • Phone: +86 176 5311 3209
  • WhatsApp: +86 176 5311 3209
  • WeChat: Zhishang17653113209
  • Skype: +86 176 5311 3209
If you want to buy denatonium benzoate anhydrous, pls contact us to get a free quote.

Application of Denatonium Benzoate Anhydrous

Bitters are currently used as aversive agents, denaturants, anti-food agents and flavoring agents. Bittersweet as an inactive ingredient is included in the United States Pharmacopeia USP32 NF27 edition. However, there are no reports on the use of bitter receptor antagonists or inverse agonists in the preparation of medicines, nor in the preparation of medicines for the treatment and/or prevention of obesity, diabetic peripheral neuropathy and neuropathic pain. Use reports. Benzammonium benzoate (bitter) is the most bitter substance known to man. Because of its low toxicity, no pollution to the environment, and no influence on other properties of the added substances, it has been used in many developed countries such as Britain, the United States, France, and Japan. Adding it to the toxic chemicals that people come into contact with in daily life and production can prevent people from accidentally ingesting them and causing poisoning.

The United Kingdom and France have published the application patents of this compound as an alcohol denaturant; in recent years, the application patents of this compound have gradually increased. For example, the Japanese patent JP 02127496 uses it as a bitter agent for alcohol-containing solid fuels, and the French patent 2726832 uses it as a refrigerant. However, benzammonium benzoate (bitter) is not used in many patents as methanol, pesticides, fungicides, plant growth regulators, rodenticides, sodium nitrite and other toxic chemicals that people come into contact with in daily life of bitters. Some studies have carried out research on benzylammonium benzoate as a bittering agent for toxic chemicals such as methanol, pesticides, fungicides, plant growth regulators, rodenticides, and sodium nitrite that people are exposed to in daily life. 30ppm) benzyl ammonium benzate amide can make the above chemicals have a bitter taste, which can effectively prevent people from accidentally ingesting the mouth.

Preparation of Denatonium Benzoate Anhydrous

Method 1: A method for synthesizing benzammonium benzoate (picro), using lidocaine, benzyl halide, benzoic acid, and metal hydroxide as raw materials, and characterized in that a two-pot method is used to synthesize benzammonium benzoate (picro) ), the two-pot synthesis process is:

Add the benzyl halide to the lidocaine-filled reactor under stirring and a certain temperature. After the reaction is complete, stop the reaction. After the obtained benzyl lidocaine ammonium halide intermediate product is purified, add the solvent and stir under stirring. Add benzoic acid, after the reaction is completed, the resulting benzammonium benzoate (picro) solution is filtered, washed, concentrated and washed to obtain the product benzammonium benzoate (picro), the reaction temperature range: room temperature to 130 ℃ , wherein the reaction temperature of the first step is preferably 50 to 105°C, and the reaction temperature of the second step and the third step is preferably room temperature to 90°C. The ratio of reaction raw materials: the ratio of lidocaine and benzyl halide is 1:1~1:2; the ratio of lidocaine, benzyl halide and benzoate is equimolar concentration, and its reaction formula is: In the formula, X=Cl, Br; M=Na, K.

Method 2: The synthetic method of benzylammonium benzoate (bitterin) comprises the following steps:

  1. Add the benzyl halide to the reactor containing the raw material lidocaine under stirring and a certain temperature, the reaction temperature is from room temperature to 130°C, and the ratio of lidocaine and benzyl halide is 1:1~1: 2;
  2. After the reaction is complete, add solvent and metal hydroxide;
  3. Add benzoic acid, after the reaction is completed, the generated benzylammonium benzoate (picro) is filtered, washed, concentrated and washed to obtain the product benzammonium benzoate (picro).


  1. Denatonium benzoate – PubChem
  2. Wang Yulan. Synthesis method of benzylammonium benzoate (bitterin). CN98100785.6
  3. Wang Yulan. Application of benzylammonium benzoate as bittering agent. CN98101236.1

Denatonium Benzoate Anhydrous Supplier and Manufacturer

As a denatonium benzoate anhydrous supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best denatonium benzoate anhydrous raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for denatonium benzoate anhydrous and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

Quality Control of Denatonium Benzoate Anhydrous

Hot Sale Products

Get Denatonium Benzoate Anhydrous Quotation

Scroll to Top