D-Mannitol CAS 69-65-8
Previous
Next
Factory Supply D-Mannitol CAS 69-65-8 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: D-Mannitol Supplier & Manufacturer
D-Mannitol: The Complete Guide
D-Mannitol for Sale
Basic Info of D-Mannitol
Basic Info
Chemical Properties
Other Info
Basic Info
Chemical Name: | D-Mannitol |
Other Name: | Mannitol; D-Mannitol CAS 69-65-8 |
CAS: | 69-65-8 |
EINECS: | 200-711-8 |
Type: | Food additives; Pharmaceutical raw materials; Organic raw materials; Sweeteners; Plant Extracts; Pharmaceuticals, Pesticides, Dye Intermediates |
Molecular Formula: | C6H14O6 |
Molecular Weight: | 182.17 |
Chemical Properties
Melting point | 167-170 °C(lit.) |
Boiling point | 295°C |
alpha | 141 º (c= USP-directives) |
density | 1.52 |
refractive index | 1.3330 (estimate) |
Fp | 290-295°C/3.5mm |
storage temp. | 2-8°C |
solubility | H2O: 1 M at 20 °C, clear, colorless |
form | Crystalline Powder |
pka | 13.5(at 18℃) |
color | White |
PH | 5.0-6.5 (25℃, 1M in H2O) |
optical activity | [α]25/D +23.3 to +24.3°(lit.) |
Water Solubility | soluble |
λmax | λ: 260 nm Amax: 0.04 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | D-Mannitol MSDS; D-Mannitol COA |
What is D-Mannitol?
D-Mannitol is a hexavalent alcohol that is extensively dispersed in plants or plant secretions. It can be removed from kelp or seaweed; it can likewise be gotten by catalytic hydrogenation of sugar or sucrose. D-mannitol is an isomer of sorbitol, an important distinction between both is: sorbitol is extremely hygroscopic, while D-mannitol is entirely non-hygroscopic, so it is a helpful Dehydrator. It can also be utilized as a diuretic, and as a sugar, flavoring representative and leavening representative in the food industry. In microbiological researches, mannitol can be used as one of the nutrients required for the development of particular microbes. It can be used to manage intracellular osmotic stress in cell biology research study.
D-Mannose can be prepared by hydrolysis of D-mannose-rich glycans (ivory palm seeds, yeast mannan, and so on). It can also be synthesized from D-mannitol (a spin-off of the iodine market from kelp) in the presence of ferrous ions by hydrogen peroxide. It can additionally be prepared by epimerization of D-glucose, or by raising the carbon chain of D-arabinose, and so on.
Mannose is not well metabolized in the human body. As a result, it is not apparent that mannose enters the carb metabolic rate process after oral management. Even if g mannose goes into from the outside, it will certainly be detected by the cells in the body. Making use of radioactive markers in mammals, 90% of consumed mannose is excreted via the urethra undamaged within 30-60 mins. 99% of the rest will certainly be secreted within the next 8 hours. During this process, the blood glucose focus does not boost significantly.
D-Mannitol Uses
- Mannitol is a good diuretic in medication, lowering intracranial stress, intraocular stress and also dealing with kidney, dehydrating agent, sugar replacement, as well as additionally made use of as an excipient for tablet computers and also a diluent for strong and liquid.
- As a hyperosmotic antihypertensive medicine, mannitol shot is a generally used medication in medical rescue, specifically in brain condition rescue. As an excipient for tablets, mannitol has no hygroscopicity, quick drying out, good chemical stability, and also has the attributes of revitalizing taste and great granulation. It is made use of in anticancer drugs, anti-bacterial medicines, antihistamines and vitamins Part of the tablet computer. In addition, it is also utilized in chewable tablets such as hangover medicine and also dental air conditioning representative.
- In regards to food, mannitol has the least water absorption amongst sugars and also sugar alcohols, and also has a rejuvenating sweet taste. It is utilized for anti-sticking of maltose, eating periodontal, rice cakes and various other foods, and as anti-sticking powder for general pastries. It can additionally be utilized as a low-calorie, low-sugar sweetener such as food for diabetic individuals and also healthy food.
- In industry, mannitol can be used in the plastics sector to make rosin esters and also man-made glycerin resins, explosives, detonators (nitromannitol), etc.
- It is used for the decision of boron in chemical analysis, and it is utilized as a microbial society agent in organic testing. Although mannitol can be taken in by the human gastrointestinal system, it does not build up in the body. After being taken in, part of it is metabolized in the body, and also the other part is secreted in pee; dibromomannitol can be obtained by the response of hydrobromic acid.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
Contact Us
- Email: sales002@sdzschem.com
- Phone: +86 176 5311 3209
- WhatsApp: +86 176 5311 3209
- WeChat: Zhishang17653113209
- Skype: +86 176 5311 3209
Facebook
Twitter
LinkedIn
Pinterest
Email
WhatsApp
If you want to buy d-mannitol, pls contact us to get a free quote.
Application of D-Mannitol
Application
Pharmacology
Application
Mannitol is a osmotic diuretic, inert to human metabolism, as well as naturally exists in vegetables and fruits in the form of sugar or sugar alcohol. Mannitol boosts plasma osmotic pressure, causing raised circulation of water from cells (consisting of mind and also cerebrospinal fluid) into interstitial liquid as well as plasma. Therefore, mind edema, enhanced intracranial stress, cerebrospinal fluid quantity and pressure might reduce. Mannitol can additionally be made use of to promote diuresis prior to irreversible kidney failure takes place; Promote urinary system excretion of toxic compounds; As an anti glaucoma representative; And as a diagnostic help for renal feature.
On October 30, 2020, mannitol was approved by FDA as an added upkeep treatment to control the pulmonary signs associated with cystic fibrosis in grown-up individuals. It is presently marketed under the name of D-Mannitol, which is odor-free white crystalline powder or free flowing bits.
Pharmacology
Molecular characteristics simulation was accomplished in the strong state as well as option state of D-Mannitol polymorph to recognize the nucleation process of spontaneous water from the tiny point of view. It is found that the molecular structure of D-Mannitol in solution is not directly pertaining to the solid state, and the type of dimer in solution may be related to the final nucleation outcome under various supersaturation. Particularly, according to the experiment, H-dimer generally shows up in the remedy with supersaturation of 1.27, where β Type nucleation. At the same time, when the supersaturation was raised to 1.90, i-dimer was discovered, as well as the δ Polymorphs. Although there was no H-dimer or i-dimer in the solution at the highest supersaturation of 2.92, as well as 2 different t-dimers were observed.
Preparation of D-Mannitol
- Using kelp as raw material, through 95% ethanol extraction, vacuum concentration, repeated column chromatography separation, petroleum ether-ethyl acetate recrystallization, and removal of residual solvent to prepare D-mannitol. Its chemical structure was identified by elemental analysis, optical rotation analysis, infrared spectroscopy, mass spectrometry and nuclear magnetic resonance. The homogeneity, stability and cooperative certification of 8 laboratories were systematically tested by high performance liquid chromatography and evaporative light scattering detector.
- Archaeal hyperthermostable mannitol dehydrogenase: a promising industrial enzyme for D-mannitol synthesis:. In particular, metabolic engineering of D-mannitol is considered to be one of the most promising approaches to produce D-mannitol on an industrial scale. To date, chemical processes have not been ideal for large-scale production due to their multi-step mechanism and high cost involving hydrogenation.
Reference
- Mannitol – PubChem
- D-Mannitol, a naturally occurring alcohol – ChemicalBook
D-Mannitol Supplier and Manufacturer
As a d-mannitol supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best d-mannitol raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for d-mannitol and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Service
FAQ
Shipping
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of D-Mannitol
Previous
Next
