D-Erythrose CAS 583-50-6

1. Prepare a structural stabilizer solution; the structural stabilizer can be borax, or boric acid, other boron-containing compounds that can generate B(OH)4- in water, and acetone, which can match the two hydroxyl groups on glucose. A substance that forms a five-membered ring or a six-membered ring; the concentration of the structural stabilizer is 0.1-2.5 mol/L, and the pH is 7-14.
2. Dissolving saccharides in the above solution; the saccharides can be penta-carbon sugars, hexa-carbon sugars, disaccharides or other polysaccharides; the concentration of the saccharides is 1wt%～50wt%.
3. Selectively add an alkaline catalyst in the above-mentioned system; in the alkaline catalyst, the homogeneous alkaline catalyst can be phosphate, hydrogen phosphate, sodium hydroxide or other substances that can make the pH of the solution between 9-14. The basic substance, the solid-phase basic catalyst can be hydrotalcite or the like.
4. The above-mentioned reaction solution is placed in an oil bath, an oven or a microwave reactor to react at a temperature of 100 to 180°C; the reaction time: microwave radiation is 1 minute-3 hours, and the oil bath or oven heating time is 1-12 hours.
5. The above reaction solution is separated by a high performance liquid chromatography preparative column to obtain D-erythrose. The separation conditions of the high performance liquid chromatography preparative column are: the column temperature is 38-45°C, and the mobile phase concentration is 0.4-0.6 mmol dilute sulfuric acid. The preferred column temperature is 40°C, and the mobile phase concentration is 0.5 mmol dilute sulfuric acid.

A new method for the production of D-erythrose from gluconic acid or its salts using the chemical: route. An aqueous solution of a gluconate salt is contacted with hydrogen peroxide in the presence of a salt of a metal selected from cobalt, nickel and ruthenium. Gluconate is to be understood as gluconic acid in free form, in lactone form or as a mixture of the two forms, in the form of a salt or in the form of an ester.

Thus, for example, calcium gluconate, sodium gluconate and delta-gluconolactone are fully suitable. The catalyst consists of ions of metals selected from cobalt, nickel and ruthenium, which can be added in the form of any divalent or trivalent, nickel and ruthenium salts. Cobalt salts are preferably used: for example cobalt acetate, cobalt acetylacetonate , Cobalt halide, cobalt nitrate, cobalt sulfate, etc. are fully applicable. The amount of catalyst (cobalt, nickel or ruthenium salt) is 0.001-50%, preferably 0.002-20%, and more preferably 0.005-5%, for the gluconate used, in the D obtained according to the above method – Good results were obtained for erythrose, both in terms of yield and purity.