Creatine Monohydrate CAS 6020-87-7

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Creatine Monohydrate Supplier & Manufacturer

Basic Info

What is Creatine Monohydrate?

Creatine monohydrate is a specific kind of creatine especially fit for usage as a nutritional supplement. Creatine monohydrate is fairly secure and also secure, and is easily taken in by the body. Taking creatine often helps restore your body’s creatine books. Until now, researchers have actually not located any kind of creatine that is a lot more efficient than creatine monohydrate.

Creatine in the body is formed from amino acids during a chemical procedure in the liver, and afterwards sent from the blood to muscle mass cells where it is exchanged creatine. The motion of human muscular tissues counts on the disintegration of adenosine triphosphate (ATP) to give power. Creatine can automatically readjust the water going into the muscle, broaden the cross-sectional muscular tissue of the muscle, and raise the explosive power of the muscle mass.

Creatine monohydrate is a pharmaceutical basic material as well as health product additive. It can prevent the generation of muscle fatigue elements, reduce tiredness and also tension, recover physical conditioning, speed up human protein synthesis, make muscle mass stronger, improve muscle flexibility, minimize cholesterol, blood fat, and also blood glucose degrees, improve muscle atrophy in middle-aged and elderly people, and also hold-up aging. Creatine monohydrate can be used as preservative, cosmetic surfactant, feed additive, beverage additive, pharmaceutical resources and health and wellness product additive, and also can likewise be directly made right into pills as well as tablets for oral management. Creatine monohydrate has a wide range of uses, however it varies in actual chemical synthesis, yet there is no high-purity and also high-efficiency synthesis technique. For that reason, the standard synthesis technique has wonderful downsides and also wastes a lot of materials.

Creatine Monohydrate Uses

The motion of human muscle mass depends on the disintegration of adenosine triphosphate (ATP) to supply energy. Creatine can instantly change the water going into the muscular tissue, increase the cross-sectional muscle of the muscle mass, and also boost the explosive power of the muscular tissue. A lot of in vivo and also artificial insemination experimental research studies have confirmed that creatine has multiple effects on the body:

  1. Increase the content of creatine in skeletal muscle mass and boost energy reserves.
  2. Control the sugar metabolism path as well as lower the production of lactic acid.
  3. Increase intramuscular glycogen shops.
  4. Rise antioxidant feature.

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The Mechanism of Action of Creatine Monohydrate in the Human Body

  1. Increase creatine content in skeletal muscle and improve energy reserve
    A large number of in vivo and in vitro experimental studies have confirmed that supplementing creatine or creatine monohydrate can increase the content of creatine in skeletal muscle and increase energy reserves. The study found that supplementing creatine monohydrate 12.5, 25, 50 g/d head for 5 days could increase the creatine content in the serum of Duroc and Landrace pigs in a dose-dependent manner, and increase the creatine phosphate content in the skeletal muscle of Duroc pigs. This shows that supplementary feeding of creatine monohydrate to livestock and poultry can improve energy metabolism of skeletal muscle by increasing the content of creatine and phosphocreatine in skeletal muscle, thereby increasing energy reserves, which is conducive to muscle growth and development, and also helps to reduce glycogen Glycolytic energization reduces lactic acid production.
  2. Regulate sugar metabolism pathway and reduce lactic acid production
    Meat color, pH and water retention are important indicators in the quality evaluation system of livestock and poultry meat. Studies have found that pH is closely related to meat color and water retention, and the rapid drop in pH is related to the lactic acid content produced by glycogenolysis. In vitro cell tests show that creatine can activate AMPK, shift basal glucose metabolism to aerobic metabolism, reduce lactic acid production, and the expression of glucose transporters and monocarboxylic acid transporters. Supplementation of creatine monohydrate can reduce lactic acid production, help alleviate the rapid drop in pH after slaughter and improve general meat quality traits, and this mechanism is different from its reduction of lactic acid by increasing energy reserves and reducing glycogenolysis produce.
  3. Increase intramuscular glycogen stores
    Increasing skeletal muscle glycogenolytic potential (glycogen level at slaughter) decreased endpoint pH and increased meat color brightness and drip loss. Muscles with low levels of glycogen and high levels of lactic acid exhibited lower pH, whereas Muscles with low levels of glycogen and lactate showed normal rates of post-mortem glycogenolysis and meat quality traits. The effect of glycogen content in skeletal muscle on the quality of livestock and poultry meat mainly depends on the ability and rate of lactic acid produced by its fermentation. Short-term high-dose creatine supplementation increased glycogen storage in rat skeletal muscle, and the improvement in oxidized muscle was more obvious than in glycolytic muscle. Creatine monohydrate regulates the increase in glucose absorption rate mainly due to the concentration of creatine phosphate rather than the ratio of creatine phosphate to creatine content. However, in another study, it was found that supplementation with creatine monohydrate did not change the content of creatine, phosphocreatine and ATP in skeletal muscle, but significantly increased the expression level of GLUT4 and the content of glycogen, which indicated that a Creatine water may increase glycogen content in skeletal muscle, and its regulation mechanism may be independent of the influence of energy metabolism regulation.
  4. Increase antioxidant function
    Creatine monohydrate has the function of protecting cells in the event of oxidative stress. Creatine monohydrate was added to in vitro stress model cells (exposed to H2O2 and tert-butyl hydroperoxide), and it was found that creatine monohydrate protected cells by directly scavenging reactive oxygen species (especially carboxyl groups) and reactive nitrogen species. Creatine can activate creatine kinase, and mitochondrial creatine kinase can reduce the production of oxygen free radicals through the ADP recycling mechanism and exert antioxidant effects. Studies have reported that creatine can significantly improve the protection of mitochondrial DNA gene activity under oxidative stress damage, which helps to maintain the stability of the mitochondrial genome, normalize mitochondrial mutations, and ensure its normal function.

Creatine and the Treatment of Muscle Diseases

Creatine supplements has actually long been taken into consideration a sensible option for the treatment of muscular, neuropathic, or neuromuscular problems. Including the treatment of arthritis, persistent congestive heart failure, disuse atrophy, annular degeneration, muscle mass phosphorylase deficiency, Huntington’s disease, varied neuromuscular illness, mitochondrial conditions, muscular dystrophy as well as neuroprotection, etc.

Two scientific researches have revealed that creatine may be valuable for neuromuscular conditions. In the initial, M. Flint Beal of Cornell University Medical Facility, an MDA-sponsored detective, demonstrated the effect of creatine, a currently prescribed medication, in prolonging liver life in mice with amyotrophic lateral sclerosis. two times the amount of riluzole. He likewise believes that the neuroprotective result of creatine in mice with ALS is mostly because of two reasons.

One is that the power available to injured nerve cells is raised, and the various other is blocking Chemical paths causing cell death. Second, a research study by 2 Canadian researchers, Mark Tarnopolsky and Joan Martin, at McMaster College Medical Center located that creatine generated moderate increases in toughness in people with various neuromuscular conditions. The most current paper was published in the March 1999 problem of Neurology.


  1. Creatine monohydrate – PubChem
  2. Schroeder C; et al. The effects of creatine dietary supplementation on anterior compartment pressure in the lower leg during rest and following exercise.

Creatine Monohydrate Suppliers and Manufacturers

As a creatine monohydrate supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best creatine monohydrate raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for creatine monohydrate and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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