Cordycepin CAS 73-03-0

At present, it is known that most Cordyceps fungi contain cordycepin, which obviously plays an important role in the anti-tumor effect. Jagger believes that there are 3 reasons why cordycepin in Cordyceps fungi inhibits tumorigenesis:

1. The free alcohol group of cordycepin can be incorporated into the DNA of cancer cells to act.
2. Cordycepin can inhibit the phosphorylation of nucleosides or nucleotides to generate diphosphate and triphosphate derivatives, thereby inhibiting the synthesis of nucleic acid in tumor cells.
3. Cordycepin can block the amination of xantholylic acid to guanylic acid.

In 1977, Müller et al. found that cordycepin had a strong inhibitory effect on the proliferation of L5718Y cells, with an ED50 of 0.27 μg; this inhibitory effect could be canceled by adenosine, but 2′-deoxynucleoside could not be canceled; with tritium The labeled Cordyceps assay showed that cordycepin could penetrate into RNA but not DNA, and cordycepin could be phosphorylated to 3′-ATP in cells; 3′-ATP had effects on DNA-dependent DNA polymerase α and β activities in L5718Y cells It has no effect, but has a strong inhibitory effect on nuclear Poly(A) polysaccharides, which will inevitably lead to mRNA maturation obstacles, which can affect the formation of mRNA and protein synthesis. The anti-tumor effect of cordycepin may be related to this mechanism. In 1997, the United States has used cordycepin in phase III clinical trials for the treatment of patients with acute pre-B and pre-T lymphocytic leukemia. At the same time, cordycepin also showed strong antifungal, anti-HIV virus and selective inhibition of shuttle. Bacterial activity.

In 1985, Jiang Ping used in vitro experiments to observe the cytotoxic effects of Cordyceps sinensis and cultured mycelium (Qinghai) on ECA cells. Results For ECA cells cultured in vitro, the total staining rate was 100% and 80% at the lowest effective concentrations of 0.405mg/ml and 25mg/ml, respectively, indicating that the drugs have different cytotoxic effects on ECA. Comprehensive in vivo experiments speculate that the anti-tumor effect is related to the drug containing a certain amount of 3′-deoxynucleoside and Cordyceps polysaccharide, as well as the overall immune regulation of the drug and the maintenance of the relative balance of the body’s immune function. Cordyceps sinensis has a certain cytotoxicity, which is consistent with the reported strong cytotoxicity of cordycepin-resistant L1210.