Cordycepin CAS 73-03-0

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  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Cordycepin Supplier & Manufacturer

Basic Info of Cordycepin

What is Cordycepin?

In 1951, German scientist Cunningham purified a crystal from Cordyceps militaris and named it Cordycepin. Since then, the anti-tumor, anti-virus, extraction and purification of cordycepin reported in foreign literatures have all been taken from cordyceps, rather than cordyceps containing only trace amounts of cordycepin.

Cordyceps sinensis is the main active component in Cordyceps sinensis (especially nucleoside). It belongs to nucleoside drugs, purine alkaloids, and is also the first nucleoside antibiotic isolated from fungi. It has become one of the leaders of modern biomedicine due to its special efficacy in repairing cells and protecting the genetic code of life. Cordycepin is a natural drug, which has many pharmacological effects, such as anti-tumor, anti-bacterial, anti-virus, immune regulation, scavenging free radicals, and has good clinical application prospects. At present, the study of cordycepin is becoming a very active field in the field of pharmaceutical chemistry.

As a structural analog of adenosine, cordycepin can inhibit Bacillus subtilis, Mycobacterium avium and Ehrlich ascites tumor cells, inhibit the RNA and DNA synthesis of cancer cells, so it has a strong inhibitory effect on human nasopharyngeal carcinoma. KD) cells. The cordycepin used in clinical practice is mostly used as an adjunctive therapy for malignant tumors, and more than 91.7% of patients have improved clinical symptoms; It is mainly used for the treatment of patients with malignant tumors such as nasal cancer, laryngeal cancer, lung cancer, leukemia and brain cancer.

Cordycepin is extracted from Cordyceps sinensis, and is the active substance with the most nutrients in Cordyceps sinensis. Its main components are cordyceps polysaccharide, cordyceps acid and cordyceps SOD, which are natural nutrients with high health functions. It can activate dormant cells, repair diseased cells, reproduce new living cells, remove dead cells, and has important value in improving immunity, anti fatigue and improving body energy.

Cordycepin Uses

  1. Antibacterial and antiviral effects
    Cordycepin is a nucleoside antibiotic with good antibacterial and antiviral effects. Cordycepin has inhibitory effects on Bacillus subtilis, Mycobacterium avium and Mycobacterium bovis. Studies have found that cordycepin can inhibit the growth of pathogenic bacteria such as Streptococcus, Bacillus pseudomallei, Bacillus anthracis, Hemorrhagic septicaemia and Staphylococcus. In addition, cordycepin also has inhibitory effects on dermatophyte pathogenic fungi such as Phytophthora gypsum and Phytophthora pedis. At the same time, cordycepin also has an inhibitory effect on the infection of human immunodeficiency virus HIV-I and its reverse transcriptase activity.
  2. Enhance immune regulation and prevent cardiovascular disease
    Cordycepin can strongly inhibit lymphocytes and monocytes, thereby preventing the body from excessive immune pathological damage, so cordycepin can regulate its own immunity.

    In addition, cordycepin can inhibit protein kinase activity and resist the cleavage of sugar groups by nucleoside phosphorylase. It has a regulating effect on humoral immunity, can increase the weight of the spleen, and accelerate the renewal rate of nucleic acid and protein in the liver; it has the functions of anti-hypoxia, increasing the blood flow of cardiac nutrient and reducing serum cholesterol, and can significantly increase the blood flow of coronary arteries and reduce coronary and cerebral blood flow. and peripheral vascular resistance, and has inhibitory effect on nucleic acid methylation, which can prevent cerebral thrombosis and cardiovascular disease.

  3. Anticancer effect
    Cordycepin has obvious anticancer effects on leukemia, lymphoma, melanoma, colon cancer, breast cancer, small cell lung cancer, pancreatic cancer, hepatocellular carcinoma, astrocytoma, pineal tumor, etc.
  4. Free radical scavenging, anti-aging effect
    Free radicals will make people more prone to aging, and cordycepin has a strong scavenging effect on free radicals. The SOD component contained in Cordyceps militaris is a typical antioxidant, which can play an antioxidant role by scavenging free radicals in the body and inhibiting lipid peroxidation. Cordyceps militaris contains a large amount of flavonoids with antioxidant and anti-aging effects, and its antioxidant activity is high and its in vitro antioxidant activity is stronger.

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Application of Cordycepin

At present, it is known that most Cordyceps fungi contain cordycepin, which obviously plays an important role in the anti-tumor effect. Jagger believes that there are 3 reasons why cordycepin in Cordyceps fungi inhibits tumorigenesis:

  1. The free alcohol group of cordycepin can be incorporated into the DNA of cancer cells to act.
  2. Cordycepin can inhibit the phosphorylation of nucleosides or nucleotides to generate diphosphate and triphosphate derivatives, thereby inhibiting the synthesis of nucleic acid in tumor cells.
  3. Cordycepin can block the amination of xantholylic acid to guanylic acid.

In 1977, Müller et al. found that cordycepin had a strong inhibitory effect on the proliferation of L5718Y cells, with an ED50 of 0.27 μg; this inhibitory effect could be canceled by adenosine, but 2′-deoxynucleoside could not be canceled; with tritium The labeled Cordyceps assay showed that cordycepin could penetrate into RNA but not DNA, and cordycepin could be phosphorylated to 3′-ATP in cells; 3′-ATP had effects on DNA-dependent DNA polymerase α and β activities in L5718Y cells It has no effect, but has a strong inhibitory effect on nuclear Poly(A) polysaccharides, which will inevitably lead to mRNA maturation obstacles, which can affect the formation of mRNA and protein synthesis. The anti-tumor effect of cordycepin may be related to this mechanism. In 1997, the United States has used cordycepin in phase III clinical trials for the treatment of patients with acute pre-B and pre-T lymphocytic leukemia. At the same time, cordycepin also showed strong antifungal, anti-HIV virus and selective inhibition of shuttle. Bacterial activity.

In 1985, Jiang Ping used in vitro experiments to observe the cytotoxic effects of Cordyceps sinensis and cultured mycelium (Qinghai) on ECA cells. Results For ECA cells cultured in vitro, the total staining rate was 100% and 80% at the lowest effective concentrations of 0.405mg/ml and 25mg/ml, respectively, indicating that the drugs have different cytotoxic effects on ECA. Comprehensive in vivo experiments speculate that the anti-tumor effect is related to the drug containing a certain amount of 3′-deoxynucleoside and Cordyceps polysaccharide, as well as the overall immune regulation of the drug and the maintenance of the relative balance of the body’s immune function. Cordyceps sinensis has a certain cytotoxicity, which is consistent with the reported strong cytotoxicity of cordycepin-resistant L1210.

Preparation of Cordycepin

Cordycepin (3′-deoxyadenosine), also known as cordycepin, cordycepin. It was first obtained by Cunningham et al. in 1951 in Cordycepsmilitaris (Link.) protoplasmic liquid, and this component has a variety of bioactive functions. Cordycepin currently mainly has the following production processes:

  • Fermentation extraction
    The production of cordycepin in the original strain is not high, and the production of cordycepin can be increased by optimizing the cultivation conditions and cultivation methods in combination with a suitable medium.
  • Biosynthesis
    Based on the genome research of Cordyceps militaris, potential synthetic gene clusters were obtained by using bioinformatics analysis method. The gene functions of the four proteins encoded by this gene cluster were studied to produce cordycepin by mediating adenosine 3′-OH phosphorylation, dephosphorylation and redox reactions.
  • Chemical synthesis
    Using adenosine as the starting material, a mild green and environmentally friendly method is used to obtain high-purity cordycepin (HPLC purity reaches 99%).


  1. Cordycepin – PubChem
  2. Cordycepin – more capable than you think – ChemicalBook

Cordycepin Supplier and Manufacturer

As a cordycepin supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best cordycepin raw materials to customers all over the world.

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