Clindamycin Phosphate CAS 24729-96-2

Clindamycin phosphate, trade name Cleocinphosphate, chemical name 6-(1-methyl-trans-1-propyl-L-2-pyrrolidinecarboxamido)-1-thio-7( S)-Chloro-6,7,8-trideoxy-L-threo-α-D-galactopyranoside-2-dihydrogen phosphate, a semi-synthetic derivative of clindamycin, It rapidly hydrolyzes clindamycin in vivo and exhibits pharmacological activity.

Clindamycin phosphate is a chemical semi-synthetic derivative of clindamycin. It is a white or off-white crystalline powder at room temperature, odorless, bitter in taste and hygroscopic. It has no antibacterial activity in vitro, and can be rapidly hydrolyzed into clindamycin after entering the body to exert its pharmacological effect.

Its mechanism of action, antibacterial spectrum, indications, and therapeutic effects are the same as those of clindamycin, but its lipid solubility and permeability are better than those of clindamycin. It can be administered orally or intramuscularly and intravenously, mainly in the liver. Metabolized, excreted in bile and feces, partially excreted in urine. Compared with lincomycin, clindamycin phosphate has 4 to 8 times stronger antibacterial effect, good absorption, high bone tissue concentration, and strong antibacterial activity against Gram-positive cocci and anaerobic bacteria. Its antibacterial spectrum is: Gram-positive cocci include penicillin G-resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus (except Streptococcus phosphate), Streptococcus pneumoniae, Micrococcus, etc.; Gram-positive bacilli include Clostridium spp. Bacillus, diphtheria, etc.; anaerobic bacteria include Clostridium, Bacteroides, Clostridium, Propionibacterium, Eubacterium, anaerobic coccus, etc.

Clinically, clindamycin phosphate is mainly used to treat tonsillitis, suppurative otitis media, sinusitis, acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia, lung abscess, bronchiectasis complicated infection and skin and soft tissue infection, such as furuncle, carbuncle , abscess, cellulitis, wound infection, burn infection, postoperative infection, etc., as well as acute urethritis, acute pyelonephritis, prostatitis, etc. of the urinary system, also used for osteomyelitis, sepsis, peritonitis, oral infection, etc.