Chloramphenicol CAS 56-75-7
Factory Supply Chloramphenicol CAS 56-75-7 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Chloramphenicol Supplier & Manufacturer
Chloramphenicol: The Complete Guide
Chloramphenicol for Sale
|Other Name:||Chloramphenicol powder; Chloramphenicol raw materials|
|Type:||Additives; Pharmaceutical raw materials; Organic raw materials; Pharmaceutical, pesticide and dye intermediates|
What is Chloramphenicol?
Chloramphenicol is a type of broad-spectrum antibiotic that can hinder the growth of bacteria generated by Streptomyces chloramphenicol. Natural chloramphenicol is L-body (additionally called levomycin). The artificial item is white or yellowish needle-like or half-cracked crystal, odorless, extremely bitter taste, slightly soluble in water, ether and also chloroform, quickly soluble in methanol, alcohol, acetone or ethyl acetate, insoluble in benzene and also petroleum ether. It is fairly secure in neutral or weakly acidic liquid option, and also it is very easy to fall short when it runs into alkali. The artificial item is a racemate, additionally referred to as Synmycin. Synthromycin is a blend of L- as well as D-forms of chloramphenicol. Due to the fact that the dextrorotary type has no anti-bacterial impact, the medicinal effect of synmycin is only half of that of all-natural products.
Chloramphenicol has inhibitory effects on Gram-negative microorganisms as well as Gram-positive microorganisms, as well as can be made use of to treat typhoid bacillary dysentery, urinary system infection, pertussis, pneumonia, blood poisoning as well as other diseases. Nevertheless, it is damaging to the liver, and also the dose and dose must purely comply with the medical professional’s recommendations. Chloramphenicol palmitate is insoluble in water, unappetizing when taken orally, additionally known as tasteless chloramphenicol. After consumption, chloramphenicol is launched by fat disintegration and enzymatic hydrolysis when going through the small intestine. Unsavory chloramphenicol has about 60% chloramphenicol, so the dose must be increased by 2/3 when taking it. Especially suitable for youngsters to take. Ointment consisting of chloramphenicol 1% can be made use of for the treatment of eye and also skin infections. In farming, it is mainly efficient against plant bacterial conditions, such as rice microbial curse, with strong systemic effect and also safe for plants.
Chloramphenicol has a wide range of activities and is effective against Gram-positive bacteria, including most drug-resistant Staphylococcus aureus, Gram-negative bacteria and anaerobic organisms. It does not work against Pseudomonas aeruginosa or Enterobacter species. For Burkholderia pseudomallei, it has little effect but has been replaced by ceftazidime and meropenem. In the West, the use of chloramphenicol is mainly limited to topical use because of its risk of causing aplastic anemia.
Initially, chloramphenicol was only used to treat typhoid fever, but now there are typhoid bacilli that can resist multiple drugs, showing that chloramphenicol can only inhibit certain bacteria. Chloramphenicol can also be used as second-line therapy for tetracycline-resistant cholera.
Because of its high permeability to CSF (much higher than that of cephalosporins), chloramphenicol is the first choice for treating brain abscesses caused by S. aureus. It is also used in the treatment of brain abscesses caused by various organisms or of unknown origin.
Chloramphenicol can effectively inhibit the three main bacteria causing meningitis: Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae. In the West, chloramphenicol is used to treat meningitis patients allergic to penicillins or cephalosporins. It is suggested that family doctors should be equipped with intravenous preparations of chloramphenicol. In some low-income countries, the World Health Organization also recommends the use of chloramphenicol oil as the first-line treatment of meningitis.
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Application of Chloramphenicol
Whole body application:
- It can be used as the first choice medicine for typhoid and paratyphoid.
- Severe diseases such as sepsis and lung infection caused by Rickettsia and other sensitive bacteria.
- Meningitis that is resistant to other drugs or has poor efficacy.
- Anaerobic infection, especially the infection involving the central nervous system.
It can be used for superficial infections of eyes and ears caused by Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, hemolytic streptococcus and other sensitive bacteria.
Chloramphenicol Side Effects
One of the most serious side effect of chloramphenicol therapy is aplastic anemia. This effect is rare, yet occasionally fatal. The danger of AA is high enough, and also choices must be thoroughly taken into consideration. Therapy is readily available but expensive. There is no chance to anticipate who may or will certainly not struggle with such negative effects. This impact typically occurs several weeks or months after the therapy is stopped, as well as may include genetic sensitivity. It is unclear whether monitoring the blood cell matter of people can protect against the advancement of aplastic anemia, however it is suggested that people should have a standard blood cell matter and also repeat the blood cell matter every couple of days throughout treatment. If the entire blood cell count decreases, chloramphenicol should be quit. The greatest threat is oral chloramphenicol (influencing one part of 24000– 40000), and the most affordable threat is eye decreases (impacting less than one part of 224716 prescriptions).
Thiamphenicol is a relevant substance with similar task spectrum, which is available for human use in Italy as well as China, and also has never been associated with aplastic anemia. Thifomycin can be used as a veterinary antibiotic in the USA as well as Europe, yet has actually not been accepted for usage in people.
- Chloramphenicol – WikiPedia
- Mulhall A, de Louvois J, Hurley R (November 1983). “Chloramphenicol toxicity in neonates: its incidence and prevention”. British Medical Journal.
Chloramphenicol Supplier and Manufacturer
As a chloramphenicol supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best chloramphenicol raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for chloramphenicol and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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