
Cetrimide CAS 1119-97-7 Tetradecyl Trimethyl Ammonium Bromide



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- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
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Basic Info of Cetrimide
Chemical Name: | Cetrimide |
Other Name: | Tetradecyl trimethyl ammonium bromide; Myristyltrimethylammonium bromide; Alkyltrimethylammoniumbromide |
CAS: | 1119-97-7 |
EINECS: | 214-291-9 |
Type: | Quaternary ammonium salt; cosmetic raw material; Pharmaceutical raw materials; Organic raw materials |
Molecular Formula: | C17H38BrN |
Molecular Weight: | 336.39 |
Melting point | 245-250 °C(lit.) |
density | 1.1328 (rough estimate) |
refractive index | 1.5260 (estimate) |
storage temp. | Store below +30°C. |
solubility | H2O: 10 % (w/v) |
form | Fine Crystalline Powder |
color | White |
PH | pH (50g/l, 25℃ : 4.0~6.0 |
Water Solubility | 20 g/100 mL |
Sensitive | Hygroscopic |
λmax | λ: 240 nm Amax: ≤0.08 |
Merck | 14,6336 |
BRN | 3633227 |
Stability: | Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
Brand Name: | Zhishang Chemical |
Provide: | Cetrimide MSDS; Cetrimide COA |
What is Cetrimide?
Cetrimide or alkyl trimethylammonium bromide is a chemical, which is a blend of 3 quaternary ammonium compounds: tetraammonium bromide (TTAB or MITMAB), cetric ammonium bromide (CTAB) and also lauryl ammonium bromide (DTAB or LTAB). It was initially uncovered and also created by ICI as well as introduced under the Cetavlon brand. It is utilized as 1-3% option to clean roadside mishap injuries. ICI additionally presented Savlon, which is a combination of Xiqumite and Xibitai. ICI later on marketed the Savlon brand name OTC to Johnson & Johnson in May 1992. Cetrimide is utilized in a range of applications, such as chemicals, diagnostic screening and analysis, topical preparations and also oral treatment.
Myristyl trimethylammonium bromide is a cationic/zwitterionic surfactant.
N. N, N-trimethyl-1-tetradecyl ammonium bromide, also called tetradecyl trimethylammonium bromide, is a quaternary ammonium salt and also a type of cationic surfactant. High pureness quaternary ammonium salt is an excellent stage transfer driver, which plays a crucial role in natural synthesis. Among them, the halogenated quaternary ammonium salt (R1R2R3R4N+X -) series substances are extensively used in day-to-day chemical market, textiles, printing and also dyeing, mining, asphalt, building, plastic processing, oil mining, petrochemical industry as well as various other areas, playing a crucial function.
Cetrimide Uses
- Cetrimide is used in ion pair chromatography, anion detergent, deodorant, catalyst, emulsifier, disinfectant, bactericide, antistatic agent and experiment.
- N, N-trimethyl-1-tetradecyl ammonium bromide can be utilized as cationic surfactant. High pureness quaternary ammonium salt is an excellent phase transfer stimulant, which plays a crucial role in organic synthesis.
- Myristyl trimethylammonium has actually been used in a study to evaluate a surfactant controlled synthesis technique to obtain mesoporous zirconia solid service nanoparticles containing cationic defects in the crystal structure. It has likewise been utilized to establish the reduced molecular weight of natural acids in dirt as well as plants by capillary area electrophoresis.
- CN201811216468.9 provides a surfactant composition applied to in vitro diagnostic reagents, belonging to the technical field of surfactants, and the components include: sucrose-glucose-6-sodium carboxylate-fructose-6-sodium carboxylate-1-(N – dodecylformamide), sodium perfluorooctanoate, N,N,N-trimethyl-1-tetradecylammonium bromide and Gemini surfactant 12-2-12, of which sucrose-glucose-6-carboxylate The content of sodium-fructose-6-carboxylate-1-(N-dodecylformamide) is 5-80mM, the content of sodium perfluorooctanoate is 10-100mM, the content of tetradecyltrimethylammonium bromide is The content is 10-100 mM, and the content of Gemini surfactant 12-2-12 is 0.1-2 mM. The invention can optimize the reaction system of the in vitro diagnostic kit, improve the performance indicators such as repeatability, inter-batch difference, accuracy, stability and the like of the kit, and help prolong the validity period of the in vitro diagnostic reagent.
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Application of Cetrimide
Chemical disinfectants are usually used to inactivate Listeria monocytogenes and other Listeria that still exist in the food processing environment after cleaning. In this study, harmless Listeria monocytogenes cultures were exposed to acid, heat, cold and starvation stresses, and then evaluated for sensitivity to the quaternary ammonium compound cetrimide. The culture without pressure and under pressure was exposed to cetrimide for 3 minutes, neutralized, and then spread on trypsin soybean agar with yeast extract to determine the percentage of survivors.
Compared with the control group, Linnocua exposed to acid and starvation was less sensitive to sitramide, while heat and cold stress increased the sensitivity of sitramide (P<0.05). The reduced sensitivity of Linnocua under acid stress and starvation stress to sitlurea suggests that these stressors may increase the persistence of this organism in food manufacturing facilities. In contrast, the increased sensitivity of L innocua to sitramide after cold and heat stress indicates that these interventions may improve the health effect.
Two types of potential electrodes were constructed for the determination of sittrazide. These sensors demonstrate advanced performance with fast response times, a lower detection limit of 4.0×10 – 6 M, and potential response M in the range 5.0×10 – 6 – 1.0×10 – 3 The sensor realizes the measurement of sittrazide in drug formulation. The sensor responds based on the ion exchange mechanism.
Compared with the Cetrimide tetraphenylborate ion pair, Cetrimide phophotoungrate has a better and more stable response. After a series of experiments, PVC membrane electrode was made. The best performance of PVC membrane electrode is achieved by a membrane composition of 30% PVC, 60% DBP and 10% ion pairs. Compared with many common exotic inorganic and organic substances, the electrode has good selectivity for cetiridine.
Preparation of Cetrimide
Weigh 400 kilograms of tetradecyl dimethyl tertiary amine and place it in 1000 liters of enamel reaction kettles, and pump 263 kilograms of hydrobromic acid, 125 kilograms of methanol and 0.4 kilograms of ionic liquid 1-ethyl- The mixture of 3-methylimidazole hydrobromide was stirred and reacted at 50° C., the reaction time was 3 hours, and the reaction was carried out under normal pressure in a nitrogen atmosphere.
After the reaction product was vacuum-dried (the drying temperature was controlled at 80° C.), it was added to the 1000L autoclave, and after the reaction kettle was flushed with nitrogen three times, 168 kilograms of dimethyl carbonate and 80 kilograms of dimethyl carbonate were pumped in at a flow rate of 20 kilograms/hour. The methanol mixture was reacted in a closed manner, the reaction temperature was 175° C., the reaction pressure was 1.7 MPa, and the reaction was carried out under stirring for 12 hours. The reaction product was vacuum dried (the drying temperature was controlled at 80°C) to obtain about 553 kg of N,N,N-trimethyl-1-tetradecylammonium bromide with a yield of 99.1% and a purity of 99.1%.
Weigh 1000g of tetradecyldimethylamine and place it in a beaker, add concentrated hydrochloric acid dropwise (HCl adds a total amount of about 151g), stir with magnetic force, and remove about 80% of the water with a constant temperature water bath after the neutralization reaction. Vacuum drying to obtain the product tetradecyl dimethyl ammonium chloride; weigh 1000g tetradecyl dimethyl ammonium chloride and 330g dimethyl carbonate respectively, add them to the 10L reactor in turn, and drive them away with nitrogen purging After the air in the kettle, the reaction is carried out in a closed state. The reaction temperature is 170 ° C. After the reaction temperature reaches 160 ° C, the stirring is started, and the reaction time is 20 hours. After the reaction is completed, N,N,N-trimethyl-1-tetradecane is prepared. ammonium bromide is about 1040g.
A preparation technique of ion-pair chromatography grade tetradecyl trimethyl ammonium bromide, the steps are as follows:
Put 180g of tetradecyltrimethylammonium bromide raw material into 720mL of solvent (the solvent is prepared from 540mL of anhydrous acetone and 180mL of anhydrous methanol); the obtained mixture is heated to 55°C, stirred for not less than 1h, and stopped Heating, adding 9 g of pretreated activated carbon with a particle size of 100 mesh to the obtained solution in batches under stirring (the activated carbon was soaked in hydrogen peroxide with a mass concentration of 30% for 8 hours, and after separation, soaked in a 6N nitric acid solution for 5 hours, and the solid-liquid separation was carried out. Washed with ionized water until neutral, vacuum dried at 100°C for 4h, vacuum degree was 0.001MPa), then heated to reflux and fully stirred for 3h, stopped heating, filtered under reduced pressure, the filtrate was cooled to room temperature, transferred to a crystallizer, left to stand and analyzed The crystallization temperature was -20 °C; the white crystals precipitated were separated by filtration, the filter cake was pressed dry, the crystals were collected, dried in vacuum, the drying time was 5 h, the temperature was 90 °C, and the vacuum degree was 0.001 MPa to obtain ion-pair chromatography grade N,N ,N-trimethyl-1-tetradecylammonium bromide 142g, can be sealed and packaged under nitrogen protection.
The obtained product was made into an aqueous solution with a concentration of C=10%, and its ultraviolet absorption value at each wavelength λ was measured:
When λ=240nm, A=0.06;
When λ=250nm, A=0.02;
When λ=260nm, A=0;
When λ=500 nm, A=0.01.
Reference
- Cetrimide – WikiPedia
- Faridbod F, Khamseh-Nejad M, Ganjali M R, et al. Cetrimide potentiometric PVC membrane sensor[J]. Int. J. Electrochem. Sci, 2012, 7(3): 1917-1926.
- Moorman M, Nettleton W, Ryser E, et al. Altered sensitivity to a quaternary ammonium sanitizer in stressed Listeria innocua[J]. Journal of food protection, 2005, 68(8): 1659-1663.
Cetrimide Supplier and Manufacturer
As a cetrimide supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best cetrimide raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
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We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
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Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
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