Model No.: CAS NO 475207-59-1
Usage:: Pharm Intermediates
Packing:: 25kg/net Drum
Molecular Weight: 636.10600
Boiling Point: 523.3ºC At 760 MmHg
CAS No:: 475207-59-1
Packaging: 25kg/net drum
Productivity: 100000kg per Month
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
HS Code: 475207-59-1
Sorafenib tosylate is a new multi-targeted anti-tumor drug developed by Bayer AG in Germany that can act on both tumor cells and tumor blood vessels. It has a dual antitumor effect: it can directly inhibit the proliferation of tumor cells by blocking the cell signaling pathway mediated by RAF / MEK / ERK, and can also inhibit the growth of tumor cells by inhibiting VEGF and platelet-derived growth factor (PDGF) receptors Blocking the formation of neovascularization, indirectly inhibiting the growth of tumor cells.
Extensive antitumor activity has been demonstrated in preclinical animal studies. In a phase III randomized clinical trial of advanced renal cell carcinoma in the United States and Europe, 903 patients with advanced renal cell carcinoma who had failed a systemic therapy (bioimmunization or chemotherapy) were randomly assigned to receive either tosylate tosylate Rafampin (Sorafenib for short) and the other for placebo. Twenty-two deaths occurred during the interim analysis. The objective and objective outcomes for both groups were 10% and 2%, respectively, and 74% and 53% of the patients had stable tumors.
1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.
2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.It is one substance or mixture during the medicine making period uut it can not be taken directly by patients.
3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. .
4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates.
5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid.