CAS NO 22457-89-2 Nootropic Benfotiamine

Basic Info

Model No.: X-CAS 22457-89-2

Appearance:: White Powder

CAS:: 22457-89-2

MF:: C19H23N4O6PS

MW:: 466.45

EINECS:: 245-013-4

Melting Point: 165 C

Storage Temp.: 2-8°C

Additional Info

Packaging:  25kg/180kg iron drum

Productivity: 1000kg per Month

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

HS Code: 22457-89-2

Port: Shanghai,Qingdao,Tianjing

Product Description

CAS NO 22457-89-2 Nootropic Benfotiamine 

Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It has been licensed for use in Germany since 1993 under the trade name Milgamma. (Combinations with pyridoxine or cyanocobalamin are also sold under this name.) Benfotiamine is a fat-soluble derivative of vitamin B1, which improves the low bioavailability of water-soluble vitamin B1 and improves the concentration of thiamine in blood and tissue, thus improving the curative effect.

Benfotiamine has been widely used in the United States, Japan, Europe and other countries around the world, its formulations are tablets, granules and other formulations It is prescribed there for treatment sciatica and other painful neck conditions.     


Benfotiamine Basic information
Product Name: Benfotiamine
Synonyms: benzoylthiamineo-monophosphate;berdi;betivina;bietamine;biotamin;btmp;neurostop;nitanevril
CAS: 22457-89-2
MF: C19H23N4O6PS
MW: 466.45
EINECS: 245-013-4
Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals
Mol File: 22457-89-2.mol


(1) for the prevention and treatment of vitamin B1 deficiency;

(2) for the increase in vitamin B1 demand, inadequate intake of food from the food (fatigue, hyperthyroidism, pregnancy, lactation, severe physical labor, etc.);

(3) for the treatment of non-alcoholic Weinick encephalopathy;

(4) for the treatment of beriberi;

(5) for the following diseases, presumably associated with vitamin B1 deficiency and metabolic disorders related to treatment, such as: neuralgia; muscle pain, joint pain; peripheral neuritis, peripheral nerve palsy; myocardial metabolic disorders; constipation and other gastrointestinal motor function obstacle.



insecticide vitamins, mineral 

circulation (cardiovascular) 

system drugs

Benfotiamine Powder to Prevent Diabetes


Test  Item

Analysis  Specification



White to almost white crystal

White to almost white crystal


A: IR spectra shows the similarity between sample and standard

B: The retention time of the major peak corresponds with it of the reference standard




Solution color and clearness

Colorless to pale-yellow clear solution



Not more than 0.053%



Not more than 0.011%


Loss on drying

Not more than 1.5%


Heavy metals

Not more than 0.002%


Related Substances

TMP :Not more than 0.15%

Benzoic acid :not more than0.1%

Amide: not more than 0.40%

Single unknown impurity: not more than0.1%

Thiamine: not more than0.1%

Total impurities: Not more than 1.5%


No detectable



No detectable


Residual solvents

Dichloromethane: not more than 600ppm

Isopropanol: not more than300ppm

No detectable


Microbial limits

Total bacteria: not more than100cfu/g

Yeast and mould: not more than50cfu/g

Escherichia coli: no detectable

<10 cfu/g

<10 cfu/g

No detectable

Assay(Dry Basis)




Complies with company Standard.

Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.

3> Fragrance And Spices: Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion.

6> Pharmaceutical Intermediates: The so-called pharmaceutical intermediates, refers to the production of pharmaceutical products in the process, the use of raw materials, materials, accessories and other intermediate products. In fact, some of the chemical synthesis process for the chemical raw materials or chemical products.

7> Agricultural Chemicals: Research and agriculture related chemical, including pesticide, plant growth regulator, fertilizer, compound fertilizer, herbicide etc.

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