CAS NO 14508-49-7 2-Chloropyrazine

Production methods: feed ratio (mass) 2 – hydroxy pyrazine: phosphorus oxychloride = 1: (8 ~ 10) in the glass-lined chlorination kettle into the 2 – hydroxy – pyrazine and phosphorus oxychloride, open the stirring, steam heating And exhaust hydrogen chloride absorption system, slowly warmed to reflux, and maintain a smooth return. After completion of the reaction, the vacuum distillation phosphorus oxychloride recovery, the residual liquid is cooled to below 40 ℃, slowly added dropwise to pre-crushed ice water treatment kettle, followed by addition of stone ether extraction 2 or 3 times, and combined extraction Phase, dried over anhydrous sodium sulfate, and then filtered, the filtrate was vacuum distillation, the first recovery of petroleum ether extractant, and finally collected 3.73kpa 59 ~ 62 ° C fraction, that is, 2-chloropyrazine. Yield ≥ 80%.
Uses: used for the synthesis of sulfasalazine.

Product expansion
1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture.
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3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.
4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates.
5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid.