CAS 1445-45-0 Trimethyl Orthoacetate

Basic Info

Model No.: X-CAS 1445-45-0

Appearance: Liquid

Source: Organic Synthesis

Name:: Trimethyl Orthoacetate

CAS:: 1445-45-0

MF:: C5H12O3

MW:: 120.14700

Density:: 0.944 G/mL At 25 °C(lit.)

Boiling Point:: -58ºC

FP:: 62 °F

Bp:: 107-109 °C(lit.)

Refractive Index:: N20/D 1.388(lit.)


Additional Info

Packaging: 25kgs packaging Fiber drum outside

Productivity: 10000kg per month

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: IN STOCK

Certificate: ISO CE

HS Code: 2915390090


Product Description

Production method

The preparation method comprises the following steps of: adding anhydrous acetonitrile, methanol and solvent carbon tetrachloride into a reaction kettle, cooling to -10 DEG C, adding metered dried HCl gas into the reaction kettle, gradually warming to 0 ~ 5 ℃, stirring was continued at this temperature for 12h to obtain a crude imino ether hydrochloride reaction mixture, the reaction solution was neutralized with 28% sodium methoxide in methanol to pH = 6.5, additional pre-cooled methanol was added Alcoholysis, the temperature is controlled at 5 ℃, and then heated to 35 ~ 40 ℃, stirring was continued for 10h, then cooled to 0 ~ 5 ℃, ammonium chloride was removed by suction filtration, the filtrate was neutralized with 28% sodium methoxide in methanol to adjust the pH = 8, and then filtered, and then distilled to remove the solvent carbon tetrachloride, and then collected 107 ~ 110 ° C fraction of trimethyl orthoacetate, the yield of up to 90%.



Testing Item



99% Min


Colorless transparent liquid

Color (APHA)


Methyl acetate content( ppm)

50 Max.

Methanol content( ppm)

200 Max.

Water Content( ppm)

500 Max.


It is used in the production of pharmaceutical and pesticide intermediates, as well as the main raw materials for food additives, coatings and paints as organic synthetic reagents.

Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.

3> Fragrance And Spices: Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, resins, additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion.

6> Pharmaceutical Intermediates: The so-called pharmaceutical intermediates, refers to the production of pharmaceutical products in the process, the use of raw materials, materials, accessories and other intermediate products.

7> Agricultural Chemicals: Research and agriculture related chemical, including pesticide, plant growth regulator, fertilizer, compound fertilizer, herbicide etc.

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