Calcium Levulinate CAS 591-64-0

A new method for the preparation of fructonate. Add 1 times ethyl acetoacetate (II), 1.2 times (molar ratio) and 5-10 times (mass ratio) of ethanol to the reactor, and stir evenly. Add 0.5-0.55 times (molar ratio) of calcium haloacetate in batches, heat up to 60 ° C after the addition, continue stirring for 4-6 hours, and obtain a mixed solution that meets calcium salts after the reaction, which can be directly used in the next step without purification. step. The calcium haloacetate is calcium chloroacetate or calcium bromoacetate.

Then most of the solvent ethanol was removed by distillation under reduced pressure, and 6-12 times (mass ratio) of 10% aqueous sodium hydroxide solution was added to the mixture, and the temperature was raised to 30 ° C after stirring evenly, and the stirring reaction was continued for 5-8 hours. To room temperature, adjust the pH of the reaction mixture to 4 with 5% dilute hydrochloric acid, then heat to 60 ° C and stir for 2 hours. During the stirring reaction, gas is generated and overflowed. The reaction is performed until no gas overflows. After cooling to room temperature again, the insolubles are removed by filtration. The obtained filtrate was distilled to remove most of the water, then a small amount of seed crystals was added, and it was left to stand for crystallization for 24 hours, and the precipitated solid was collected by filtration.

A new method for preparing calcium nephritonic acid by supplementing calcium, characterized in that the product is obtained by directly reacting fructonic acid (L-levulinic acid or levulinic acid) with calcium hydroxide. Production process: add the metered calcium hydroxide into the reactor, add water, dissolve it under stirring, add fructonic acid dropwise at room temperature (20 ~ 25 ℃), make the reaction complete PH=6.7, then decolorize, filter, Freeze, crystallize at low temperature (0～5℃), filter, wash with water and dry to obtain finished product.

The application of this new calcium-supplementing preparation calcium fructonate is characterized in that: it can be used as a food nutrition fortifier, fortified calcium nutrition, and can be used in soy sauce, condiments, beer, beverages, soft drinks, milk and milk products, soy milk and soy products . It can be used alone or compounded with calcium lactate, calcium chloride and other calcium agents. For medicine, it can be made into tablets, capsules, injections or compounded into injections.