Calcium Gluconate CAS 299-28-5
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Factory Supply Calcium Gluconate CAS 299-28-5 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Calcium Gluconate Supplier & Manufacturer
Calcium Gluconate: The Complete Guide
- Item 1: Basic Info of Calcium Gluconate
- Item 2: What is Calcium Gluconate?
- Item 3: Calcium Gluconate Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Calcium Gluconate
- Item 6: Preparation of Calcium Gluconate
- Item 7: Quality Control of Calcium Gluconate
- Item 8: Hot Sale Products
- Item 9: Get Calcium Gluconate Quotation
Calcium Gluconate for Sale
Basic Info of Calcium Gluconate
Basic Info
Chemical Properties
Other Info
Basic Info
Chemical Name: | Calcium Gluconate |
Other Name: | calcium gluconate iv; ca gluconate; calcium gluconate bnf; calcium gluconate medscape; calcium d gluconate |
CAS: | 299-28-5 |
EINECS: | 206-075-8 |
Type: | Food additives; Pharmaceutical raw materials; Plant extracts; intermediates for pharmaceuticals, pesticides, dyes |
Molecular Formula: | C12H22CaO14 |
Molecular Weight: | 430.37 |
Chemical Properties
Melting point | 195°C |
alpha | 10.2 º (c=1, H2O 22 ºC) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Sparingly soluble in water, freely soluble in boiling water. |
form | Crystals or Crystalline Powder |
color | White |
PH | pH;6.0～8.0 |
Water Solubility | 3.3 g/100mL |
Hydrolytic Sensitivity | 0: forms stable aqueous solutions |
Stability: | Stable. Incompatible with strong oxidizing agents. |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Calcium Gluconate MSDS; Calcium Gluconate COA |
What is Calcium Gluconate?
Calcium gluconate (calcium gluconate) is the calcium salt of gluconic acid, the molecular formula is C12H22CaO14 H2O, the molecular weight is 448.40, the melting point is 201 ° C, it is a white crystal or powder, odorless and tasteless, soluble in cold water, easily soluble in hot water , Insoluble in absolute ethanol, chloroform or ether. Calcium gluconate is an important organic calcium. It is clinically used as a calcium supplement and a raw material for the production of other gluconates (zinc gluconate, iron gluconate, etc.) and glucono delta-lactone. It is an important chemical industry in my country. export product. Calcium gluconate is mainly used as calcium fortifier and nutrient, buffer, solidifying agent and chelating agent in food. Glucose and calcium carbonate were mixed together, glucose oxidase and catalase were added, and calcium gluconate was directly obtained by oxidation at 37°C.
Calcium gluconate is a mineral supplement and drug. As a drug, it is administered intravenously to treat hypocalcemia, hyperkalemia and magnesium poisoning intravenously. Supplements are usually needed only when calcium is insufficient in the diet. Supplementation can treat or prevent osteoporosis or rickets. It can also be taken orally, but injection into muscle is not recommended.
Side effects during injection include decreased heart rate, pain at the injection site and hypotension. Side effects of oral administration may include constipation and nausea. The blood calcium level should be measured when using, and those with a history of kidney stones should be extra careful . At normal doses, it is considered safe to use during pregnancy and lactation.
Calcium Gluconate Uses
- Calcium gluconate is an important organic calcium. It is mainly used as a calcium fortifier and nutrient, buffer, solidifying agent and chelating agent for food, and has a very broad application prospect.
- As a drug, calcium gluconate can reduce capillary permeability, increase density, maintain normal excitability of nerves and muscles, enhance myocardial contractility, and help bone formation.
- Calcium gluconate is indicated for allergic conditions such as urticaria; eczema; pruritus; contact dermatitis, and serum sickness; angioedema as adjunctive therapy. It is also used for the prevention and treatment of calcium deficiency.
- As a food calcium fortifier, calcium gluconate has better absorption effect than inorganic calcium. my country stipulates that it can be used in cereals and their products, and the dosage is 18-36g/kg; in milk beverages and drinking liquids, it is 4.5-9.0g/kg.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Medical Use of Calcium Gluconate
Hypocalcemia
10% calcium gluconate solution (intravenous administration) is the most widely used calcium agent in the treatment of hypocalcemia. This form of calcium is not absorbed like calcium lactate. It contains only 0.93% (930 mg / dl) calcium ions (defined as 1 g by weight of solute in 100 ml solution to make 1% solution w / V). Therefore, if hypocalcemia is acute and severe, calcium chloride should be given instead.Hyperkalemia
Calcium gluconate is used as a cardioprotective agent in people with high blood potassium levels. An alternative is to use calcium chloride. It is recommended when the potassium level is high (> 6.5 mmol / L) or the electrocardiogram (ECG) shows changes due to hyperkalemia.
Although it has no effect on the level of potassium in the blood, it can reduce the excitability of cardiomyocytes and reduce the possibility of arrhythmia.- Magnesium sulfate excess
It is also used to counteract excess Epsom magnesium sulfate, which is usually used in pregnant women to prevent seizures (such as patients with preeclampsia). Magnesium sulfate is no longer given to pregnant women undergoing preterm birth to slow or stop uterine contractions (due to better efficacy and side effects, other uterine contractions are now used instead). [need to quote] excessive magnesium sulfate can lead to magnesium sulfate poisoning, resulting in respiratory depression and loss of deep tendon reflex (hyporeflexia). - Hydrofluoric acid burn
Calcium gluconate gel is used to treat hydrofluoric acid burns. Calcium gluconate reacts with hydrofluoric acid to form insoluble and non-toxic calcium fluoride. In addition to using 2.5% calcium gluconate gel directly for chemical burns, patients may also receive calcium gluconate supplements because fluoride ions precipitate serum calcium, resulting in hypocalcemia. - Cardiac arrest
Although intravenous calcium has been used for cardiac arrest, it is not recommended for general use. Still recommended cases of cardiac arrest include hyperkalemia, hypocalcemia (e.g. that may occur after blood transfusion) and excess calcium channel blockers. General use may worsen the results. If calcium is used, calcium chloride is usually the recommended form.
Preparation of Calcium Gluconate
Method 1
Method 2
Method 1
- Neutralization reaction
Add gluconolactone to the batching tank, and at the same time add pure water or condensed water, so that the mass fraction of the gluconolactone solution is 15-22%, and the prepared gluconolactone solution is pumped into the neutralization barrel, Carry out stirring, slowly add CaCO3 or Ca(OH)2 in the stirring process, open the steam valve of the neutralization tank, use the jacket of the neutralization tank to slowly heat up, control the temperature to be 80-85 ℃, keep the temperature for 20-30 minutes, The pH is 6.5-7.5 to obtain calcium gluconate solution; - Decolorization and filtration
After the neutralization reaction is completed, add activated carbon to the neutralization barrel in an amount of 0.3-0.5% (mass fraction), stir, the rotating speed is 25-35 rpm, the temperature is 80-85 ° C, and the decolorization is 30-40 minutes. , to obtain calcium gluconate solution; add perlite, diatomite and water to the pre-coating tank for ingredients, the mass ratio of perlite, diatomite and water is 40:20:1000, stir for 10 minutes to obtain a pre-coating solution , use the precoating pump to drive the precoating liquid into the plate and frame filter press at a pressure of 0.2MPa to precoat the filter cloth. After the coating is completed, turn on the material pump to drive the neutralized and decolorized calcium gluconate solution into the plate and frame pressure. Filtration is carried out in the filter, the filtration pressure is 0.5MPa, and the plate and frame filtrate is obtained after filtration. When the transmittance is ≥99%, the plate and frame filtrate is injected into a precision filter with a precision of 0.1-0.5um; When the luminosity is less than 99%, return the plate and frame filtrate to the neutralization bucket, and return the pre-coating solution to the pre-coating tank; the plate and frame filtrate is filtered by the precision filter and then poured into the decolorizing solution storage tank; - Spray drying
Use a high-pressure screw pump to pump the calcium gluconate solution in the decolorizing liquid storage tank into the spray drying tower of the spray drying device for spray drying. During the spraying process, control the feeding pressure of the screw pump to be 0.3-0.6MPa; the air inlet of the spray drying tower The temperature is 150-180℃, and the air outlet temperature is 75-85℃; the moisture content of calcium gluconate after drying is ≤0.5%; - Packaging process
The dried calcium gluconate is separated by a cyclone and then enters the silo, and then goes through an automatic packaging line for finished product packaging.
Method 2
- Pretreatment of turmeric starch: Mix turmeric starch with water to make the mass percentage of starch in the starch milk 20% to 30%, stir and adjust the paste, and then put it into a high-pressure container, under a pressure of 0.1 MPa～ 0.15 MPa, boil at 120℃～125℃ for 20min～30min, after taking it out, add sodium hydroxide solution or saturated lime aqueous solution at 0.1mol/L～1mol/L to adjust the pH value of starch milk to 6.0～6.5, at 85℃ Ultrasonic vibration for 30min-60min at ~95℃;
- Enzymatic liquefaction: Add bacterial α-amylase to the starch milk according to the amount of enzyme required per gram of dry starch, 8U-15U, stir and mix for 10-30 minutes, and after mixing evenly, carry out at 80-100°C Steam jet liquefaction, after the steam jet liquefaction is completed, the temperature is further increased to 20°C to 30°C, and the temperature is kept for 20min to 30min to kill the enzyme to obtain a starch liquefaction solution;
- Enzymatic saccharification: Cool the starch liquefaction solution to 55℃～60℃, add sodium hydroxide solution or saturated lime aqueous solution to the starch liquefaction solution in the ratio of 0.1mol/L～1mol/L to adjust the pH value to 4.0～ 4.5, and add saccharification enzyme according to the required amount of enzyme per gram of dry starch, 150U~200U, keep saccharification for 40h~50h, after checking that there is no dextrin, adjust the pH value of the liquid to 4.8~5.0, and heat it to 80℃~85 ℃, keep the temperature for 20min～30min to kill the enzyme to obtain starch saccharification solution;
- Impurity removal and decolorization of the saccharified liquid: The starch saccharified liquid is filtered to remove insoluble impurities to obtain a clear saccharified liquid. 1.5% activated carbon was decolorized, stirred for 30min-60min, vacuum filtered, filtered off the activated carbon, and obtained a colorless saccharification solution;
- Glucose catalytic oxidation: measure the glucose content of the colorless saccharification solution, add Pd/C catalyst to the colorless saccharification solution according to the mass ratio of glucose and catalyst in the colorless saccharification solution of 10:1 to 50:1, and Introduce compressed air or oxygen, conduct water bath stirring, the temperature of catalytic reaction is controlled at 45℃～48℃, the amount of compressed air or oxygen is 40m3/h～50m3/h, and the stirring speed is 1500r/min～2000r/min. During the catalytic reaction process, add sodium hydroxide solution or saturated lime aqueous solution to the colorless saccharification solution at a ratio of 0.1 mol/L to 1 mol/L, control the pH value of the colorless saccharified solution to be 9.0 to 9.5, and sample and measure the colorless saccharified solution. When the residual glucose content is lower than 1%, the catalytic reaction is stopped, and the vacuum filtration is carried out. The filtrate is sodium gluconate or calcium gluconate solution, and the filter residue is a recovered catalyst, which is dried for the next use;
- Product refining: filter sodium gluconate or calcium gluconate solution to remove insoluble impurities to obtain a clear solution, control the temperature of the clear solution at 65°C to 75°C, and add 1.0% to 1.5% mass fraction of activated carbon to the clear solution to decolorize , stir for 30min～60min, vacuum filtration, filter out the activated carbon to obtain a colorless transparent sodium gluconate or calcium gluconate solution, then vacuum concentration and evaporation at 55℃～65℃, after crystallization or spray drying, white crystals or powders are obtained Calcium gluconate finished product.
Reference
- “Calcium gluconate Use During Pregnancy | Drugs.com”. www.drugs.com. Archived from the original on 18 January 2017. Retrieved 15 January 2017.
- British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 680, 694. ISBN 9780857111562.
- “Calcium Salts”. The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
Calcium Gluconate Supplier and Manufacturer
As a calcium gluconate supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best calcium gluconate raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for calcium gluconate and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Calcium Gluconate
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