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Boron Trifluoride-Acetic Acid Complex CAS 373-61-5

Factory Supply Boron Trifluoride-Acetic Acid Complex CAS 373-61-5 with Best Price

  • Appearance: Clear light yellow to yellow-brown liquid
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Boron Trifluoride-Acetic Acid Complex Supplier & Manufacturer

Basic Info

What is Boron Trifluoride-Acetic Acid Complex?

Boron trifluoride acetic acid, also known as boron trifluoride acetic acid complex, is a flammable acidic corrosion product, flammable, and decomposes when heated or exposed to water. It is a colorless liquid, and the commercial product is a gray-yellow to brown liquid containing about 40% boron trifluoride. It is corrosive and decomposes when it meets water.

Boron Trifluoride-Acetic Acid Complex Uses

  1. Boron trifluoride acetic acid is an acid by-product, primarily used as a stimulant for organic synthesis.
  2. Boron trifluoride acetic acid, also known as boron trifluoride acetic acid complex, is a chemical reagent that can be used in organic synthesis as an organic raw material.
  3. Boron trifluoride acetic acid complex  is an important raw material and intermediate for organic synthesis, medicine, pesticides and dyes. It is also used as a demethylsilylation agent. It is also used for the orthodemethylsilylation of phenyl as part of the conversion of dimethylphenylsilyl to hydroxy and the maintenance of configuration.

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Application of Boron Trifluoride-Acetic Acid Complex

  • Preparation of Furotriptan Succinate
    CN201410799863 discloses a preparation method of furatriptan succinate, which belongs to the technical field of drug synthesis and organic compound synthesis and preparation. Furotriptan was developed by Ireland’s Elan Pharm acutieallne, and was approved by the US FDA in November 2001 in the form of its succinate (1:1) for the acute treatment of migraine with or without aura. Frova. At present, this product is not registered for sale in China. The preparation method uses 4-cyanophenylhydrazine hydrochloride as the starting material, and N-methyl-1,4-dioxaspiro[4.5]decane-8-amine hydrochloride is cyclized in hydrochloric acid, and the After splitting L-pyroglutamic acid, use boron trifluoride acetic acid complex to catalyze hydrolysis, and then use succinic acid to form a salt to obtain the finished furovatriptan succinate. The method makes up for the deficiencies of the prior art, has simple synthesis process, stable yield and high purity, and is suitable for industrial production.

  • Synthesis of 2,4-dichlorobenzoic acid, an antimalarial drug aldipine hydrochloride drug intermediate
    2,4-Dichlorobenzoic acid is white to light yellow needle-like crystal or powder, which is used as an intermediate in the production of dyes, pesticides, fungicides, and pharmaceuticals. The pharmaceutical industry is used to manufacture the antimalarial drug Adipine hydrochloride. But existing synthetic method mostly adopts potassium permanganate and dichlorotoluene to do reactant reaction, and process is more complicated, and final yield is not very high, therefore, be necessary to propose a kind of new synthetic method, this is useful for further improving The quality and yield of the product and the reduction of by-product content are of great economic significance.

    CN201710157448.8 provides a kind of synthetic method of antimalarial drug aldipine hydrochloride pharmaceutical intermediate 2,4-dichlorobenzoic acid, comprising the following steps:

    (i) Add 4-5mol of N,N-dimethylacetamide solution and 3-4mol of boron trifluoride acetic acid powder into the reaction vessel, control the stirring speed at 90-110rpm, keep it for 30-40min, then add 2mol of 2,4-dichloro-6-amino-isobutylbenzene solution, raise the temperature of the solution to 40-50°C, keep it for 100-130min, continue to raise the temperature to 60-70°C, keep it for 30-40min, precipitate out, filter , the precipitate is washed with 1-chloro-2-methylpropane solution, the filtrate and washing liquid are combined, the oxalic acid solution is added to adjust the pH value to 4-5, the temperature of the solution is lowered to 10-15°C, crystals are precipitated, filtered, dehydrating agent is dehydrated, In the finished product 2,4-dichlorobenzoic acid.

References

  1. Boron trifluoride acetic acid complex – PubChem
  2. CN201410799863.X A preparation method of furatriptan succinate
  3. CN201710157448.8 A kind of synthetic method of antimalarial drug aldipine hydrochloride drug intermediate 2,4-dichlorobenzoic acid

Boron Trifluoride-Acetic Acid Complex Supplier and Manufacturer

As a boron trifluoride-acetic acid complex supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best boron trifluoride-acetic acid complex raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for boron trifluoride-acetic acid complex and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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