Best selling products Ethyl 2-bromopropionate cas 535-11-5

Best selling products Ethyl 2-bromopropionate cas 535-11-5

Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.

production method
1. Obtained from the bromination of hexanediol: In a 500 mL flask with a reflux condenser, 58 g of 1,6-hexanediol and 6.84 g of red phosphorus were added. The mixture was heated to 100-150°C with stirring, and 80 g of bromine was added dropwise. After the addition was complete, stirring was continued at this room temperature for 1 h. The reaction was cooled to room temperature and diluted with water. Add 100 mL of ether and filter off excess red phosphorus. The dibromide solution in diethyl ether was separated and washed sequentially with 10% sodium sulfate solution and water. Dry with anhydrous calcium chloride. Distilling off the ether, vacuum distillation, collecting 114 ~ 115 ° C (1.6kPa) fractions, to obtain the finished product 85g, the yield was 71%.1. Prepare bromoacetic acid by reacting bromine with acetic acid and acetic anhydride in pyridine, and then react with bromoacetic acid and ethanol in the presence of sulfuric acid to form ethyl bromoacetate. It is generally prepared in two steps. 1 Preparation of bromoacetic acid: 3L glacial acetic acid and 100mL acetic anhydride were added to the flask, and 15g of red phosphorus or 70g of phosphorus tribromide was added, heated to 100°C with stirring, and 300mL (900g, 5.6mol) was slowly dropped from the separating funnel. ) Bromide, the reaction has an induction process, do not add too fast, so as to avoid sudden reactions. After the start of the reaction (with HBr released), maintain a temperature between 90°C and 100°C, and slowly add 2.0L of bromine (2.3L in total, 41 mol). After the addition, continue stirring and heating to turn the brown-red liquid into orange red. Since then, it has rarely been released. Unreacted acetic acid was recovered to a distillation temperature of 140°C and approximately 1L was recovered for the next synthesis. 2Esterification: The crude bromoacetic acid was poured into another 10L flask, 5L of industrial ethanol and 200 mL of sulfuric acid were added, refluxed on a boiling water bath for 12 hours, ethanol was recovered, washed with saturated brine three times, and dried after drying over anhydrous sodium sulfate. , collect 154 ~ 158 ° C distillate, get 2.4 ~ 2.6kg.production method
The preparation method comprises the following steps: propionic acid and red phosphorus are put into a reaction bottle; bromine is added dropwise at 60° C. for about 3 hours, heated up to 100-120° C., stirred for 6 hours in heat preservation, cooled, filtrated, filtrate is heated and distilled, and then fractionated to obtain 2 – Bromopropionyl bromide, the product of 2-bromopropionyl bromide reacted with absolute ethanol. The reaction equation is as follows: CH3CH2COOH+Br2[P]→CH3CHBrCOBr+H2OCH3CHBrCOBr+C2H5OH→CH3CHBrCOOC2H5+HBr
use
Ethyl α-bromopropionate is the herbicides quizalofop, oxazoloxaprofen, thiazoxapolfarin, flupiracin, pirfenoxadol, chlorfluazuron, metolachlor , Napropamide and bactericide metalaxyl, benalaxyl, procymidone and other intermediates. For organic synthesis intermediates and solvents.

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Q1. Are you a manufacturer

Answer: Yes, we have our own factory called [ZhiShang Industry Group “, we export by ShandongZhishangchemical Co., Ltd. 

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Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.

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Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment. 

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Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping.

You also can choose your own shipping forwarder.

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Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.It is one substance or mixture during the medicine making period, it can not be taken directly by patients.

3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid.