Best selling products 1 6-Dibromohexane CAS 629-03-8

Best selling products 1 6-Dibromohexane CAS 629-03-8

1,6-Dibromohexane is used as a reagent in the synthesis of novel benzo[b]xanthone derivatives which have potential antitumor activity. It is also used as a cross-linker for the cross-linking of glycuronans.

production method
1. Obtained from the bromination of hexanediol: In a 500 mL flask with a reflux condenser, 58 g of 1,6-hexanediol and 6.84 g of red phosphorus were added. The mixture was heated to 100-150°C with stirring, and 80 g of bromine was added dropwise. After the addition was complete, stirring was continued at this room temperature for 1 h. The reaction was cooled to room temperature and diluted with water. Add 100 mL of ether and filter off excess red phosphorus. The dibromide solution in diethyl ether was separated and washed sequentially with 10% sodium sulfate solution and water. Dry with anhydrous calcium chloride. Distilling off the ether, vacuum distillation, collecting 114 ~ 115 ° C (1.6kPa) fractions, to obtain the finished product 85g, the yield was 71%.
2. Method: In a reaction flask equipped with a stirrer, thermometer, reflux condenser, dropping funnel, add 1,6-hexanediol
(2) 59g (0.5mol), red phosphorus 6.84g, slowly added to 100 ~ 150 °C under stirring, bromine 80g (0.5mol) was added dropwise, after the addition was continued in this temperature range reaction 1h. Cool to room temperature, pour into cold water, filter unreacted red phosphorus. Extract three times with ether, combine the ether solution, wash sequentially with 10% sodium thiosulfate, water and dry over anhydrous calcium chloride. Distilled off the ether, vacuum distillation, collecting 114 ~ 115 °C / 1.6kPa fractions, to get 1,6- dibromohexane …
use
Organic synthesis intermediates for the production of hypotensive drugs hexamethamphetamine.

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1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture.

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