Best selling 3-Pyridyl bromide 626-55-1

Best selling 3-Pyridyl bromide 626-55-1

Description

Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.

Physicochemical properties
Appearance and traits: transparent yellow to brown liquid
Density: 1.64 g/mL at 25 °C (lit.)
Melting point: -27°C
Boiling point: 173 °C (lit.)
Flash point: 125 °F
Refractive index: n20/D 1.571 (lit.)
Stability: Stable under normal temperatures and pressures.
Storage conditions: The warehouse ventilation is low temperature and dry, separate from the acid and oxidant.

Production method

Production method 1 Preparation of pyridine hydrobromide high bromine compound In a 500 mL three-neck flask, add 9.1 g (1 mol) of pyridine, and add dropwise 113 ml (2 mol) of 48% hydrobromic acid under stirring and cooling in ice water. Later changed to oil bath heating, dewatering under the pressure of the pump to reach the final temperature of 160 °C. The residue in the bottle should be completely dry pyridine hydrobromide. 240 g of glacial acetic acid was added to the bottle, and the mixture was heated to completely dissolve. The solution of 80 g (25.5 mL) of bromine and 80 mL of glacial acetic acid was gradually added from the dropping funnel while stirring at 50 to 60°C. The reaction was poured into a 1L beaker, covered with a glass surface, and allowed to crystallize. The needle-like crystals of a red-brown pyridine hydrobromide bromide were precipitated. After cooling to 10°C, the mixture was suction filtered, pressed dry, and air-conditioned. During drying, approximately 190 g of product was obtained with a yield of 59.4%. m·p·101~104°C. Preparation of 23-bromopyridine The dry pyridine hydrobromide high bromide compound prepared above was added to the obtained pyridine hydrobromide, and a reflux condenser was installed on the three-necked flask. The top of the condenser was connected with calcium chloride. The tube is then connected to a bottle filled with water to absorb hydrogen bromide and a thermometer is inserted in the other port. The remaining one is plugged with a stopper and the mixture is placed in an oil bath and heated to 235° C. (inside bottle temperature) and maintained. At this temperature of 8 h, the reaction started at 200° C., ie, hydrogen bromide evolved, and yellow crystals precipitated in the condenser tube. When no more bromine chloride evolved, the reaction was completed, heating was stopped, and cooling was performed. The cold-solidified reactants were subjected to steam distillation to remove the 3,5-dibromopyridine and 1500 mL of the distillate was distilled off. After filtration, 10.5 g of 3,5-dibromopyridine crystals were obtained.

USE

For organic synthesis

FAQ

Q1. Are you a manufacturer

Answer: Yes, we have our own factory called [ZhiShang Industry Group “, we export by ShandongZhishangchemical Co., Ltd. 

Q2. Do you have GMP or DMF

Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.

Q3. What information should I let you know if I want to get a quotation

Answer: -Quality you require, eg. Assay, Purity, or single impurity

-Quantity you need

-Standard you want, such as USP, EP, JP etc.

Q4. How to make the payment

Answer: Escrow and T/T in advance are highly recommended. We can accept Western Union, Money Gram and Paypal as well

Q5. When will you deliver the goods

Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment. 

Q6. How will you deliver the goods

Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping.

You also can choose your own shipping forwarder.

Q7. When will we receive the goods

Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most. 

Q8. What if we find your products unsatisfied

Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.

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