Best Price of High Purity 99.8% Acitretin/Etretin 55079-83-9

Basic Info

Model No.: LYN- 55079-83-9

Shelf Life: 2 Years

Form:: Powder

CoA: Available

Sample: Free

CAS: 55079-83-9

Name:: Acitretin, Acitretin

Additional Info

Packaging:  25kg/Drum

Productivity: 10000kg

Brand: zhishang

Transportation: Ocean,Land,Air

Place of Origin: Shandong, China (Mainland)

Supply Ability: in stock

Certificate: ISO CE

Port: Shanghai,Tianjin,Qingdao

Product Description

Best Price of High Purity 99.8% Acitretin/Etretin 55079-83-9 

Product Introduction

 

Acitretin ,Etretin CAS 55079-83-9

C A S : 55079-83-9

Chemical name : acitretin, etretin (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid

Quality Standard : EP2000
Package : 1,2kg kg/tin .

Storage : Preserve in tight containers, preferably under an atmosphere of an inert gas, protected from light, at a temperature between 2°C and 8°C.
Stock amount:10kg/month

Appearance:yellow crystalline powder

Solubility: practically insoluble in water,  sparingly soluble in tetrahydrofuran, slightly soluble in acetone and in alcohol, very  slightly soluble in cyclohexane. It is sensitive to air, heat and light, especially in  solution. Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis. It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin’s half-life is approximately 2 days. Because acitretin can be reverse metabolised into etretinate which has a long half life, women must avoid becoming pregnant for at least 2 years after discontinuing acitretin. Therefore, etretinate is generally not recommended for women of child bearing age with a risk of becoming pregnant. Acitretin is the least toxic systemic treatment for psoriasis. It is an oral retinoid of choice used in the treatment of severe resistant psoriasis. It binds to nuclear receptors that regulate gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer. If a patient has received the medication, he/she is advised against giving blood for at least 3 years due to the risk of birth defects. 

 

 Specification

  For the treatment of psoriasis (severe refractory cases, including erythrodermic andgeneralized pustular), severe refractory oral lichen planus, keratosis refractory severeintractable disorders (such as ichthyosis-like skin disease, congenital ichthyosis-likeerythroderma, lamellar ichthyosis and other ichthyosis), follicular keratosis, palmoplantarkeratosis, pityriasis rubra pilaris, palmoplantar pus fibromatosis.

Function                     

1.  Acitretinis widely applied in pharmaceutical field, mainly used for the cure of dermatonosus like acne, ichthyosis and psoriasis abnormal, etc..

2.  For skin keratinocytes-resistant drugs and cell-induced differentation drug.

Specification

Analysis contents

Analysis standard BP2010

Analysis results

Appearance

A yellow or greenish-yellow,
crystalline powder

White crystalline powder

Identification

Positive

Positive

Clarity of solution

Clear

Clear

Color of solution

≤BY7

< BY7

Assay

99.0-100.0%

99.9%

Loss on Drying

≤0.4%

0.03%

Residue on ignition

≤0.1%

0.03%

Sulphate Ash

≤0.1%

0.03%

Specific rotation

+20.5°~ +21.5°

+20.96°

PH(with 2% water solution)

2.4-2.8

2.55

PH(with 5% water solution)

2.1-2.6

2.30

Melting range

About 190°C

191°C

Heavy Metals

≤3ppm

<3ppm

Iron

≤2ppm

<2ppm

Copper

≤5ppm

<5ppm

Oxalic Acid

≤0.2%

<0.2%

Arsenic

≤1ppm

<1ppm

Lead

≤3ppm

<3ppm

Cadmium

≤1ppm

<1ppm

Organic volatile impurities

Meets the requirements

conform

 

 

Related Substance

 

Impurity C  ≤0.15%

Impurity D  ≤0.10%

Any other Unspecific Impurities Impurity≤0.10%

Total Impurity  ≤0.2%

 

 

Complies

Total Plate Count

≤1,000cfu/g

<1, 000cfu/g

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