Benzethonium Chloride CAS 121-54-0
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Benzethonium Chloride Supplement
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Benzethonium Chloride: The Complete Guide
- Item 1: Basic Info of Benzethonium Chloride
- Item 2: What is Benzethonium Chloride?
- Item 3: Benzethonium Chloride Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Benzethonium Chloride
- Item 6: Synergistic Bactericidal Effect of Benzethonium Chloride and Polyhexamethylene Biguanide
- Item 7: Quality Control of Benzethonium Chloride
- Item 8: Hot Sale Products
- Item 9: Get Benzethonium Chloride Quotation
Benzethonium Chloride for Sale
Basic Info of Benzethonium Chloride
Basic Info
Chemical Name: | Benzethonium Chloride |
Other Name: | Benzethonium chloride español; benzethonium chloride usp; haiamine |
CAS: | 121-54-0 |
EINECS: | 204-479-9 |
Type: | Pharmaceutical raw materials; Pharmaceutical, pesticide, dye intermediates; Cosmetic raw materials |
Molecular Formula: | C27H42ClNO2 |
Molecular Weight: | 448.08 |
Chemical Properties
Melting point | 162-164 °C (lit.) |
density | 0.998 g/mL at 20 °C |
vapor pressure | < 0.001 hPa @ 2°C |
refractive index | 1.5650 (estimate) |
storage temp. | 2-8°C |
solubility | H2O: 0.1 M at 20 °C, clear, colorless |
form | Liquid |
color | White |
Odor | Odorless |
PH | 5.5-7.5 (25℃, 0.1M in H2O) |
PH Range | 5.5 – 7.5 |
Water Solubility | 1-5 g/100 mL at 18 ºC |
Sensitive | Hygroscopic |
Stability: | Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents, soap, anionic detergents, nitrates, acids. Light sensitive. |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Benzethonium Chloride MSDS; Benzethonium Chloride COA |
What is Benzethonium Chloride?
Benzethonium chloride is a brand-new sort of quaternary ammonium antibacterial agent, which is commonly made use of in everyday chemicals and also cosmetics sectors. Additionally, as an antiseptic as well as antibacterial agent, it additionally has important applications in the field of medication and also wellness. For instance, it has actually been extensively made use of in Western nations as a bacteriostatic element of eye decreases or as a bacteriostatic element of injection. In the production of heparin sodium products, benzethonium chloride is a vital intermediate.
Benzalkonium chloride, additionally known as haiamine, is an artificial quaternary ammonium salt. The substance is an odorless white strong, soluble in water. It has the characteristics of surfactant, preservative and anti infection, and is used as a local anti-bacterial agent in emergency situation chemicals. It also exists in cosmetics as well as toiletries, such as soap, mouth wash, antipruritic lotion and also antibacterial wipes. Benzalkonium chloride is additionally made use of as a difficult surface disinfectant in the food sector.
Benzethonium Chloride Uses
- Benzethonium chloride with surfactant, preservative as well as anti infective homes. It has microbicidal activity versus a variety of microorganisms, fungi, molds and viruses. It was likewise located to have considerable broad-spectrum anticancer task.
- In the daily chemical sector, benzethonium chloride is additionally extensively utilized in anti-bacterial wipes as an antiseptic ingredient, with a yearly dose of tens of lots, and the demand for benzethonium chloride in the entire day-to-day chemical market is rapidly increasing, and the dosage will certainly increase swiftly. In the field of cosmetics and also ecological disinfection, benzethonium chloride is also very popular, and the range of promo and application as well as the marketplace prospect are really wide.
- Benzethonium chloride as a preservative in cosmetics; Cationic surfactant. As an anti-bacterial for milk products as well as food industry. Scientific reagent for identifying healthy protein in cerebrospinal liquid; Pharmaceutical additives (chemicals).
- Benzethonium chloride are quickly soluble in water and also other solvents, Can be developed as a powder or liquid household or commercial fungicide disinfectant. It can likewise be made use of as a disinfectant or anti-bacterial agent for topical vet and also specialty drugs, used according to the directions for use, and also is not corrosive to ecological surfaces. Phenylethylammonium chloride used in studies to analyze minimum inhibitory concentrations of methicillin-resistant Staphylococcus aureus (MRSA) separated from Malaysia; made use of in research studies to prepare biocomposite membranes using sodium alginate as well as changed clays Benzalkonium chloride is a chemical, which can resist algae, germs and fungis. In skin care products, 0.5% focus is safe.
- Hyamine (R) 1622 crystals is an FDA approved topical component. It can be made use of as a bactericide, antiperspirant or preservative for a range of applications, including individual treatment, vet and also pharmaceutical.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Application of Benzethonium Chloride
Antibacterial
Benzalkonium chloride has broad-spectrum microbicidal task versus bacteria, fungi, molds and also infections. Independent tests revealed that benzalkonium chloride worked versus methicillin-resistant Staphylococcus aureus, Salmonella, Escherichia coli, Clostridium difficile, liver disease B virus, liver disease C virus, herpes simplex virus (HSV), human immunodeficiency infection (HIV), breathing syncytial virus (RSV) and also norovirus.The USA Fda (FDA) states that the secure and also efficient focus of benzalkonium chloride in emergency products is 0.1-0.2%. The aqueous solution of benzalkonium chloride is not soaked up by the skin. It is not accepted as a preservative in the USA as well as Europe. As a quaternary ammonium salt, it is much more hazardous than adversely billed surfactants. However, in a two-year rat study, there was no evidence of carcinogenic task.
Its trade names consist of salanine, BZT, diapp, quatrachlor, polymer D, phemithyn, antiseptol, disilyn, phermerol, and so on. It likewise exists in a number of grapefruit seed remove prep work and also can be used as chemicals, such as the anesthetics ketamine and also afaxadone.
Various other usages
Along with its high anti-bacterial activity, benzalkonium chloride additionally includes a favorably charged nitrogen atom, which is covalently adhered with 4 carbon atoms. This positive cost attracts it to the skin and also hair. This assists to produce a soft, grainy feel on the skin and hair after usage, in addition to enduring task versus microorganisms. On top of that, this favorably charged hydrophilic part of the molecule makes it a cationic detergent.Benzalkonium chloride is additionally used to titrate the quantity of sodium dodecyl sulfate in the mixture of salt dodecyl sulfate, sodium chloride as well as sodium sulfate, utilizing brominated diimide sulfur blue as an indicator.
It precipitates into turbidity with anionic polymers in liquid solution, that makes it feasible to estimate the quantity of such polymers in the example. This examination is utilized for commercial and also commercial water therapy, in which polyacrylates, polymaleates and also sulfonated polymers are typically used as dispersants.
- Methyl benzyl ammonium chloride
Relevant compounds (25155-18-4) are utilized to treat extreme Leishmania infection.
Synergistic Bactericidal Effect of Benzethonium Chloride and Polyhexamethylene Biguanide
Benzethonium Chloride Sterilization
- Benzethonium chloride has good bactericidal effect on Escherichia coli and Staphylococcus aureus.
- When the mass fraction of benzethonium chloride is 0.02%, the bactericidal rate of the two bacteria is close to 100%. Therefore, when benzethonium chloride is used alone, an appropriate content (0.02% is sufficient) can be selected accordingly.
- The bactericidal effect of benzethonium chloride on Staphylococcus aureus is slightly better than that on Escherichia coli.
PHMB sterilization
- PHMB also has a strong bactericidal effect on the above two bacteria.
- When the mass fraction of PHMB is lower than 0.01%, the bactericidal rate of fungicides against Staphylococcus aureus increases faster. When the mass fraction of PHMB reaches 0.01%, the sterilization rate of both bacteria has exceeded 90%, which has reached the sterilization standard of general hygiene products (90%). When the mass fraction of PHMB is 0.02%, the bactericidal effect can be considered. Therefore, when PHMB is used alone, the quality fraction of 0.02% can be selected.
- Both PHMB and benzethonium chloride are high-efficiency fungicides. In daily use, these two fungicides do not need to use high content for sterilization, and can achieve good sterilization effect at lower content (0.02%).
Synergistic sterilization of benzethonium chloride and PHMB
- When benzethonium chloride and also PHMB are used alone, the sterilization rate is lower than that of mixed usage, that is, the two fungicides have a collaborating sanitation result. As well as when the mass fraction of benzethonium chloride is about 50%, the antiseptic rate gets to the greatest value, the bactericidal rate of the combined bactericide versus Escherichia coli is close to 80%, and also the antiseptic price against Staphylococcus aureus is close to 90%. That is, when both fungicides are configured in a proportion of 1:1, the best synergistic impact can be put in. Both fungicides revealed a synergistic bactericidal impact. The possible reason is that both of them are cationic surfactants, however the relative molecular weights of both fungicides are fairly various. The family member molecular mass of benzethonium chloride is little, and also the relative molecular mass of polyhexamethylene biguanide is high, so the sterilization device of both might be different. For th at reason, when they are made use of in combination, the bacteria will certainly be ruined according to their particular sterilization systems, as well as the general mortality of the microorganisms will certainly increase.
- The above discovers the collaborating impact of the mixed bactericide with an overall mass portion of 0.0005%. When the ratio of benzethonium chloride and PHMB is 1:1, the bactericidal price of Escherichia coli and also Staphylococcus aureus can get to 80% respectively ., 90%. In the actual manufacturing of hygienic items, the sterilization requirement is 90%. Therefore, it is needed to discover the synergistic effect of the overall mass fraction of combined fungicides higher than 0.0005%.
- Benzethonium chloride and also PHMB are configured in a proportion of 1:1 to accomplish the best synergy, so the proportion of both in the combined fungicide is figured out to be 1:1, and the overall mass portion of the evaluated combined fungicide is 0.001% and 0.005%.
When benzethonium chloride and PHMB are utilized alone, the antiseptic rates of the two versus Escherichia coli and Staphylococcus aureus are both near 100% when the mass fraction is 0.02%; the other 2 have collaborating bactericidal effect, as well as when the two are 1 : 1: The best sanitation impact can be accomplished when the percentage of 1 is used in a combined arrangement. Under the optimal proportion of the two (1:1), the sanitation price of the above two microorganisms is close to 100% when the The total mass fraction of the mixed bactericide is 0.005%.
Reference
- Benzethonium chloride – WikiPedia
- Benzethonium chloride – PubChem
- “Evaluation of the synergistic bactericidal effect of benzethonium chloride and polyhexamethylene biguanide”
Quality Control of Benzethonium Chloride
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