Avobenzone CAS 70356-09-1
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Factory Supply Avobenzone CAS 70356-09-1 with Best Price
- Appearance: White to pale yellow powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Avobenzone Supplier & Manufacturer
Avobenzone: The Complete Guide
Avobenzone for Sale
Basic Info
Basic Info
Chemical Properties
Other Info
Basic Info
| Chemical Name: | Avobenzone |
| Other Name: | 4-Tert-butyl-4′-methoxy-dibenzoylmethane; UV ABSORBER TRUELICHT UV 1789 |
| CAS: | 70356-09-1 |
| EINECS: | 274-581-6 |
| Type: | Cosmetic raw materials; Pharmaceutical raw materials; Organic raw materials |
| Molecular Formula: | C20H22O3 |
| Molecular Weight: | 310.39 |
Chemical Properties
Melting point | 81-84 °C |
Boiling point | 463.6±35.0 °C(Predicted) |
density | 1.079 |
vapor pressure | 0Pa at 25℃ |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
pka | 9.74±0.13(Predicted) |
form | neat |
color | White to Pale Yellow |
Water Solubility | 27μg/L at 20℃ |
Other Info
| Brand Name: | Zhishang Chemical |
| Provide: | Avobenzone MSDS; Avobenzone COA |
What is Avobenzone?
Sunlight is an indispensable substance for the survival of all things in the world. A moderate amount of ultraviolet radiation is beneficial to human health and enhances human physique. The 400 nm long-wave ultraviolet rays can cause harm to the human body. Therefore, in order to protect the human body from the damage of ultraviolet radiation, we widely use ultraviolet absorbers with safe and efficient ultraviolet absorption in textiles, paints, sunscreens, cosmetics and other products.
There are many kinds of ultraviolet absorbers, among which benzophenone ultraviolet absorbers are widely used, and this kind of absorbers has great practical research value. Avobenzone [chemical name: 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione] belongs to benzophenone UV absorbers, and is also A very important organic synthesis intermediate.
Avobenzone, Chinese name: butylmethoxydibenzoylmethane, is a rare organic sunscreen that can absorb UVA1, and UVA1 has the largest span in ultraviolet rays, and it is also a band area that most ultraviolet absorbers cannot prevent: 340-400 nm.
The significance of UVA protection is quite large, which may be more important than sun protection: UVA reaching the surface of the earth has reached 95% of the total ultraviolet rays, and until recently scholars have discovered that UVA is not only the main cause of skin photoaging, but also involved in cancer caused by sunlight process. Compared with only 10% of UVB can reach the uppermost dermis, 20%-30% of UVA can reach the dermis.
Avobenzone Uses
Avobenzone is an artificial ultraviolet absorber, an excellent UV-A (> 320nm) type ultraviolet absorber, which can block UVA in the entire band (320-400nm), as well as is a reliable broad-spectrum oil-soluble UVA Light filter, Intensified with other UVB sunscreens, can give full UVA as well as UVB defense for the prevention of photoinduced skin cancer.
The study found that avobenzone can significantly disrupt the interaction between the two proteins PHB and c-Raf1, and confirmed for the first time that avobenzone can significantly inhibit the metastasis of colon cancer cells through molecular biology experiments and cytology experiments. The scope of application of avobenzone has been expanded, and its application value has been improved. Compared with traditional chemotherapeutic drugs, avobenzone has high tumor specificity, less side effects and clearer countermeasures for side effects.
Compared with the existing tumor-targeted drugs, avobenzone does not target a single gene or protein, but targets the interaction of two proteins, and does not exert continuous drug pressure on specific molecules or single proteins in cancer cells. It leads to mutations, which greatly reduces the emergence of clinical drug resistance.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
Contact Us
- Email: sales002@sdzschem.com
- Phone: +86 176 5311 3209
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If you want to buy avobenzone, pls contact us to get a free quote.
Avobenzone Functions and Side Effects
Features
Security Measures/Side Effects
Features
An oil-soluble sunscreen. Identified as a “chemical” sun block due to the fact that it functions by absorbing a broad wavelength of UV rays, converting them into less dangerous infrared radiation (heat energy). It is marketed as a “broad-spectrum” sunscreen due to the fact that it stands up to the complete series of UVA rays. It is one of minority sunscreens with a wide variety of UV defense, so it is extensively utilized in sun block products. It is utilized in cosmetics to also protect against various other components from weakening in the sun.
The examination results showed that avobenzone often tends to break down dramatically with raising sun direct exposure time, thereby minimizing its sunlight defense capacity. For this reason, many sunscreens containing this ingredient include photostabilizers such as octocrylene. Lots of firms have actually developed innovations to assist maintain this component (eg Helioplex ™, Active Image Obstacle Complicated ™), nevertheless, the full threats of long-lasting use of avobenzone have actually not been established.
Security Measures/Side Effects
Avobenzone seems relatively nontoxic and also nonirritating to the skin. Nevertheless, because it is commonly used with photostabilizers, there is a danger of skin inflammation as well as low poisoning. Some researches have revealed that it can be absorbed by the body and excreted in the pee, so it is not advised for kids and expectant ladies. Some skin experts believe it is as hazardous as PABA, and some researches have actually revealed that this active ingredient acts like the hormonal agent estrogen; nonetheless, the European Payment for Cosmetics as well as Inedible Products refuted the latter claim.
Both the U.S. Fda and also the EU Cosmetic Directive take into consideration the ingredient risk-free, accepting its secure use at focus of 3 percent and also 5 percent, specifically.
Stability
Avobenzene is sensitive to the properties of solvents, relatively stable in polar proton solvents, and unstable in non-polar environments. In addition, when it is exposed to UVA light, it will produce a triple excited state in the form of ketone, which will lead to the degradation of Avobenzene or transfer energy to biological targets and cause harmful effects.
Avobenzene has been shown to degrade significantly under light, resulting in reduced protection over time. In a mild climate, UV-A light in sunlight is enough to break down most compounds. The data submitted to the Food and Drug Administration by the Association of Cosmetics, Toiletries and perfume shows that the ultraviolet absorption rate of avobenzone has changed by – 36% after one hour of exposure to sunlight. This degradation can be reduced by the use of light stabilizers, such as Octalin.
The photostability of Avobenzene can also be improved by compounding it with cyclodextrin. Avobenzone and hydroxypropyl- β- The formulation of cyclodextrins shows a significant reduction in photo induced degradation and a reduction in the transdermal penetration of UV absorbers when used at high concentrations.
When sunscreens contain antioxidant compounds, the photostability of avobenzone will be further improved. Mangiferin, glutathione, ubiquinone, vitamin C, vitamin E β- Carotene and trans resveratrol have been proved to have the ability to protect avobenzone from photodegradation. The stability and efficacy of avobenzone seem to continue to increase as more antioxidants are added to the sunscreen.
According to some studies, “the most effective sunscreens contain Avobenzene and titanium dioxide.” When Avobenzene is used in combination with mineral ultraviolet absorbers (such as zinc oxide and titanium dioxide), it can degrade faster under light, but if the correct mineral particle coating is used, this reaction can be reduced. Manganese doped titanium dioxide may improve the stability of Avobenzene more than undoped titanium dioxide.
Reference
- Avobenzone – WikiPedia
- Yang J, Wiley C, Godwin D, Felton L (June 2008). “Influence of hydroxypropyl-β-cyclodextrin on transdermal penetration and photostability of avobenzone”. European Journal of Pharmaceutics and Biopharmaceutics.
Avobenzone Suppliers and Manufacturers
As a avobenzone supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best avobenzone raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for avobenzone and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Service
FAQ
Shipping
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Avobenzone
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