Arachidonic acid CAS 506-32-1

Because the desaturase activity in infants and young children is very low, even if enough linoleic acid is taken in, the amount of AA required for growth and development cannot be synthesized. The fetus obtains AA from the mother through the placenta and accumulates it, and then obtains AA from breast milk and diet after birth. AA deficiency in fetuses and infants may be caused by low levels of AA in maternal blood or limited diets during artificial feeding. In view of the fact that AA is an essential nutrient for early human development and has special effects on fetal and infant central nervous system and retinal neurodevelopment, AA is mainly used in nutritional supplements for pregnant women and formula foods for infants and young children. AA is a natural component of breast milk. Decades of research in countries around the world have found that the average composition of breast milk is relatively consistent across the world, and the content of AA is between 0.5% and 0.7%. It is abundant in breast milk and almost absent in cow’s milk.

In 1994, in the report “Fats, Oils and Human Nutrition” submitted by joint experts of the United Nations Food and Oil Organization and the World Health Organization, new dietary guidelines were proposed, and it was recommended that infants and young children should consume AA through diet, and the recommended amount was “full-term”. 40mg per kilogram of body weight per day for infants and 60mg per kilogram per day for premature infants”. Since then, governments have successively approved AA as a nutritional fortifier to be added to baby food. In 1999, my country’s Ministry of Health officially recognized AA as a new type of nutritional fortifier. By the end of 2001, nearly 100 countries had approved the addition of AA to infant and young children’s food. In nutritional supplements for pregnant women, experts suggest adding a certain proportion of AA in addition to DHA (docosahexaenoic acid). The content in maternal blood and milk can not only bring good brain and optic nerve development to the fetus, but also reduce the incidence of prenatal eclampsia and postpartum depression in pregnant women, and also has a good regulatory effect on patients with gestational diabetes.

Because AA and its metabolites have strong biological activity in the human body, AA can be used as a functional active factor to make functional foods suitable for different groups of people or oral liquids suitable for special groups. Experts believe that it will become a functional food development. new growth point. AA has the functions of lowering blood sugar, blood lipids, preventing cardiovascular diseases, improving immunity, and increasing blood vessel elasticity. AA metabolites can also be used to relieve nervous tension, regulate central nervous system function, and play an important role in the prevention and treatment of cardiovascular and cerebrovascular diseases. , such as prostaglandins, leukotrienes, thromboxane. AA is the main essential fatty acid, which is closely related to lipid metabolism and is also important for cholesterol metabolism. Not only does it not cause hyperlipidemia and obesity like saturated fatty acids, on the contrary, it helps cholesterol transport and metabolism, preventing cholesterol deposition in the blood vessel wall and developing into atherosclerosis, which in turn plays a role in preventing hypertension and coronary heart disease. , myocardial infarction, cerebrovascular disease and other diseases prevention. Therefore, AA as a functional food has broad application prospects and great commercial value

In the past 20 years, the requirement of essential fatty acids in fish has been extensively studied at home and abroad. It is generally believed that the demand for arachidonic acid in fish is slow and can be met by the arachidonic acid contained in the feed (fish meat and fish oil), however, at a particular stage of the fish life cycle, high levels may be required. Arachidonic acid to adapt to the environment. AA is beneficial to fish growth, survival and resistance to stress; promote fish reproduction, improve the quality of eggs, sperm and seedlings; regulate fish immune function. Therefore, AA-rich fish feeds have broad market prospects.

In addition to being widely used in health food, AA is also widely used in cosmetics. AA is similar in function to γ-linolenic acid, but the skin care effect of AA is better than that of γ-linolenic acid; AA can replace or partially replace γ-linolenic acid to produce high-end skin care cosmetics; AA also has the functions of nourishing hair follicles and promoting hair regeneration , so it can also be used to develop hair care products, which can prevent and treat hair loss. Similar products have come out abroad. For example, Japan’s Shiseido has added AA to cosmetics to make skin care, hair care, anti-wrinkle and other beauty products to protect skin moisture. , delaying skin aging and treating chronic eczema. AA has a wide range of applications in the medical field. More than 90% of high-purity AA is very effective in treating hypertension, preventing pregnancy, induced abortion, relieving bronchial asthma, nasal congestion, and digestive system ulcers.