Model No.: X-CAS 154598-52-4
Exact Mass:: 315.02700
BP: 340.6ºC At 760 MmHg
Packaging: 25 kg in on fiber drum
Productivity: 100000kg per month
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE API
HS Code: 154598-52-4
1. p-Chloroaniline dissolved in chloroform and saturated aqueous sodium carbonate solution, dropping 2,2-dimethyl propionyl chloride. After adding, the mixture was stirred at room temperature, and the solid was collected by filtration. The filtrate was separated and the separated chloroform layer was washed with brine, dried and concentrated. The concentrated material was recrystallized from the boiled ethyl acetate-hexane with the solid obtained above to give N-2,2-dimethylpropionyl p-chloroaniline. The organic compound was separated from each other by adding hydrochloric acid and ethyl acetate. The organic layer was washed with brine, dried, and dried under reduced pressure, and the residue was dissolved in tetrahydrofuran.
The resulting material was refluxed in hydrochloric acid, cooled, added with ethyl acetate and adjusted to basic with concentrated ammonia. The organic layer was separated, washed with brine, dried and concentrated to give 2-trifluoroacetyl-4-chloroaniline. The cyclopropylacetylene is dissolved in tetrahydrofuran and the ethyl ether solution of ethyl magnesium bromide is added dropwise. After completion of the reaction, 2-trifluoroacetyl-4-chloroaniline is added and a saturated aqueous solution of ammonium chloride is added dropwise. Extracted with ethyl acetate.
The extracts were combined, washed with brine, dried and concentrated to give the alkylated product. And carbonyl diimidazole was dissolved in anhydrous tetrahydrofuran. The solvent was then distilled off under reduced pressure, and ethyl acetate and water were added. The aqueous layer was extracted with ethyl acetate. The extract and the organic layer were combined, washed with hydrochloric acid, saturated sodium bicarbonate and brine, dried and concentrated under reduced pressure to give racemic efavirenz. Reacting it with (-) camphyl chloride in methylene chloride and then adding hydrochloric acid in n-butanol to isolate the optically active efavirenz.
We strictly complying with ISO9001 and ISO 2000 standard in manufacturing process, our lab and workshop tightly in accordance with GMP standard.
1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the raw material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture.
2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.It is one substance or mixture during the medicine making period uut it can not be taken directly by patients.
3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.
4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, additives, and other intermediates.
5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid.
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