
Amino-2-Propanol CAS 78-96-6
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- Appearance: Colorless liquid
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Amino-2-Propanol Supplement



Amino-2-Propanol: The Complete Guide
- Item 1: Basic Info of Amino-2-Propanol
- Item 2: What is Amino-2-Propanol?
- Item 3: Amino-2-Propanol Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Amino-2-Propanol
- Item 6: Preparation of Amino-2-Propanol
- Item 7: Quality Control of Amino-2-Propanol
- Item 8: Hot Sale Products
- Item 9: Get Amino-2-Propanol Quotation
Amino-2-Propanol for Sale
Basic Info of Amino-2-Propanol
Chemical Name: | Amino-2-Propanol |
Other Name: | 2 Amino 2 methyl propanol; 1-Amino-2-propanol; DL-IsopropanolaMine; (±)-1-Amino-2-propano; 1-Aminopropan-2-ol |
CAS: | 78-96-6 |
EINECS: | 201-162-7 |
Type: | Pharmaceutical raw materials; Organic raw materials |
Molecular Formula: | C3H9NO |
Molecular Weight: | 75.11 |
Melting point | -2 °C (lit.) |
Boiling point | 160 °C (lit.) |
density | 0.973 g/mL at 25 °C (lit.) |
vapor density | 2.6 (vs air) |
vapor pressure | <1 mm Hg ( 20 °C) |
refractive index | n20/D 1.4478(lit.) |
Fp | 165 °F |
storage temp. | 2-8°C |
pka | 12.92±0.35(Predicted) |
form | Liquid |
color | Clear |
Odor | slt ammonia odor |
PH | 11.3 (10g/l, H2O, 20℃) |
explosive limit | 1.9-10.4%(V) |
Water Solubility | freely soluble |
FreezingPoint | 1.4℃ |
Sensitive | Hygroscopic |
Stability: | Stable. Substances to be avoided include strong oxidizing agents. Combustible. Hygroscopic. |
Brand Name: | Zhishang Chemical |
Provide: | Amino-2-Propanol MSDS; Amino-2-Propanol COA |
What is Amino-2-Propanol?
1-Aminopropan-2-ol is an organic compound with the chemical formula CH 3 CH (OH) ch2nh 2. It is an amino alcohol. The term isopropanolamine can also refer more generally to other homologues diisopropanolamine (Dipa) and triisopropanolamine (TIPA).
1-Aminopropan-2-ol is chiral. It can be prepared by adding ammonia water to propylene oxide.
Amino-2-Propanol Uses
1-Amino-2-propanol (MIPA, Amino-2-Propanol) is an essential great chemical resources with a large range of uses. It is commonly utilized as surfactants, metal functioning fluids, paints and finishes, fabric printing as well as dyeing, individual treatment items, water treatment representatives, and also intermediates of pharmaceuticals and pesticides. One of the raw materials of the body. The main uses of 1-amino-2-propanol (isopropanolamine) are as complies with:
- The response with fat produces fatty acid isopropanolamide (alkyl isopropanolamide) and also ester, due to its excellent lathering buildings, foam stability as well as the capability to dissolve grease, it can be made use of as industrial artificial detergent.
- The item gotten from thioglycolic acid can be made use of as a cosmetic base.
- Because of its good hygroscopicity and also weak alkalinity, it can be utilized as a raw material for surfactants, and can be made use of as improving agents, antistatic representatives, dyeing accessories as well as fiber wetting agents in the fiber industry.
- Its phosphate and also nitrite can be made use of as anti-oxidants for numerous lubricating oils as well as cutting oils.
- The reaction items with numerous acids and greater aliphatic ketones can be used as plasticizers, emulsifiers and solvents. The isopropanolamine mix has a specifically strong dissolving capacity to hydrocarbons. Mix kerosene, halogenated hydrocarbons, naphtha, and so on together with isopropanolamine (4%) as well as oleic acid (15%) in water to get a secure solution. The salts formed with long-chain fats can be made use of as emulsifiers for vinyl acetate resins, with good solution stability and secure shade.
The Manager has Something to Say

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Application of Amino-2-Propanol
CN201310281153.3 discloses a new process for synthesizing tenofovir disoproxil, using (R)-(-)-1-amino-2-propanol as raw material to react with p-toluenesulfonyloxymethyl diethyl phosphate, Then through hydrolysis and condensation to obtain (R)-2-O-[bis(isopropoxycarbonyloxymethyl)phosphono-methyl]-1-amino-2-propanol (IV), the obtained formula (IV) ) compound is condensed with 5-amino-4,6-dichloropyrimidine, and tenofovir disoproxil is obtained by ring closure and aminolysis. The invention provides a new tenofovir disoproxil synthesis process, which has low production cost, process safety, good product quality and is suitable for industrialized production.
Preparation of Amino-2-Propanol
Propylene oxide and ammonia water with a concentration of 95wt% in a molar ratio of 1:1.0 were respectively input into the mixer with a metering pump, and the temperature in the mixer was controlled to be 0°C and the pressure was 3.0MPa; the mixture was continuously fed into the microchannel for reaction In the reactor, the material reacts in the channel of the reaction section of the reactor, the temperature is 60 °C, the pressure is 3.0 MPa, and after staying for 0.1 s, it enters the cooling section of the microchannel reactor to rapidly cool down to terminate the reaction, the outlet temperature is 0 °C, and the temperature is 0 °C. The time is 2S, and the specific cooling rate is controlled at about 1800-2000°C/min.
Then, the low boilers are removed through a stripping tower to obtain the product 1-amino-2-propanol with a content of 99.2%. In this embodiment, the microchannel reactor is specifically made of stainless steel, wherein the inner diameter of the microchannel is 0.05mm, and the length of the microchannel is 0.8m.
A preparation method of (S)-1-amino-2-propanol, specifically comprises the steps:
Dissolve sodium tert-butoxide (230g, 2.39mol) in tetrahydrofuran (2L), slowly add trifluoroacetamide (226g, 2mol) under ice bath, stir for 30min; then add (S)- Propylene oxide (128 g, 2.2 mol) was naturally heated to room temperature, continued to stir for 10 h, and was stirred for 2 h at 35 °C; after the reaction, 2N (equivalent) hydrochloric acid was added dropwise to the system for a total of 1 L for neutralization, and then replenished 1 L of water was added, the layers were left to stand, the aqueous phase was extracted with dichloromethane, the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain a total of 318 g of intermediate product I with a yield of 93%. 1H-NMR (CDCl3, 400MHz) of intermediate product I:
δ 1.08 (d, 3H), 3.37 (m, 2H), 4.0 (m, 1H), 7.12 (brs, 1H).
The intermediate product I (310 g, 1.81 mol) obtained in step (1) was dissolved in methanol (1.5 L), 200 mL of water and potassium carbonate (550 g, 4 mol) were added, stirred at room temperature for 6 h, filtered, and concentrated to dryness, The obtained product was dissolved in dichloromethane, filtered to remove insoluble matter, dried over anhydrous sodium sulfate, concentrated, and distilled under reduced pressure to obtain the target product (S)-1-amino-2-propanol, a total of 122 g, with a yield of 90%. .
1H-NMR (CDCl3, 400MHz): δ 1.15 (d, 3H), 2.43 (dd, 1H), 2.64 (dd, 1H), 3.53-3.64 (m, 1H), 3.77 (brs, 3H).
A preparation method of (R)-1-amino-2-propanol, specifically comprises the steps:
Dissolve sodium tert-butoxide (300g, 3.12mol) in tetrahydrofuran (2L), slowly add trifluoroacetamide (294g, 2.6mol) under ice bath, stir for 30min; then add (R) under ice bath – Propylene oxide (166g, 2.96mol) was naturally heated to room temperature, continued to stir for 10h, and then stirred for 2h at 35°C; after the reaction, a total of 1.3L of 2N (equivalent) hydrochloric acid was added dropwise to the system for neutralization, Then 1.3 L of water was added, the layers were left to stand, the aqueous phase was extracted with dichloromethane, the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain a total of 423 g of intermediate product I with a yield of 95%.
1H-NMR (CDCl3, 400 MHz) of intermediate I: δ 1.07 (d, 3H), 3.36 (m, 2H), 3.99 (m, 1H), 7.11 (brs, 1H).
Dissolve the intermediate product I (420g, 2.45mol) obtained in step (1) in methanol (2L), add 350mL of water and potassium carbonate (744g, 5.4mol), stir at room temperature for 6h, filter, and concentrate to dryness, The obtained product was dissolved in dichloromethane, filtered to remove insoluble matter, dried over anhydrous sodium sulfate, concentrated, and distilled under reduced pressure to obtain the target product (R)-1-amino-2-propanol, a total of 171 g, with a yield of 93% .
1H-NMR (CDCl3, 400 MHz): δ 1.17 (d, 3H), 2.45 (dd, 1H), 2.66 (dd, 1H), 3.54-3.67 (m, 1H), 3.76 (brs, 3H).
Reference
- 1-Aminopropan-2-ol – PubChem
- [Chinese invention] CN201810777252.3 A kind of preparation method of 1-amino-2-propanol
Quality Control of Amino-2-Propanol

