SHANDONG ZHISHANG CHEMICAL CO.LTD
Model No.: X-CAS 1134-47-0
Appearance:: White Powder
Packaging: 25kg/180kg iron drum
Productivity: 1000kg per Month
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
HS Code: 2922499990
High quality CAS 1134-47-0 Baclofen
Baclofen, sold under the brand name Lioresal, among others is a central nervous system depressant used as a skeletal muscle relaxant. It is primarily used to treat spasticity. It is also used as a muscle relaxant by compounding pharmacies in topical pain creams.
It is a GABA receptor agonist, specifically of the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. It is a derivative of γ-aminobutyric acid (GABA).
A beneficial property of baclofen is that tolerance to its muscle-related therapeutic benefits does not seem to occur to a significant degree - baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use. Newer studies, however, indicate that tolerance may develop in some people receiving intrathecal baclofen treatment. As of 2015 the cost for a typical course of treatment in the United States is less than 25 USD.
The ethyl methyl - diacetyl acetate was formed by condensation of chlorobenzaldehyde and ethyl acetoacetate. The hydrolysis of heated water is applied to the chlorphenyl glutaric acid. Chlorinated phenyl glutaric anhydride was formed by anhydride dehydration. In the end, the chlorophenyl-butyric acid was decomposed by using a strong ammonia amine. The final open loop and degradation are performed as follows: 42.25g beta - (for chlorphenyl) glutaramide, which is stirred and added to the 200ml aqueous solution containing 8.32g of sodium hydroxide. Mixture in 10 min 50 ℃ heating, cooling and 10-15 ℃, add 200 ml water solution containing 40.9 g of sodium hydroxide, after 20 min, add 38.8 g bromine, stir in 20 to 25 ℃ 8 h, will carefully with concentrated hydrochloric acid reaction liquid pH value to 7, then the settling of fine beta - (on) - gamma amino butyric acid crystallization, again by recrystallization in water, melting point 206-208 ℃.
1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.
2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.
3> Fragrance And Spices: Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.
4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, resins, Additives , and other intermediates.
5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion.
6> Pharmaceutical Intermediates: The so-called pharmaceutical intermediates, refers to the production of pharmaceutical products in the process, the use of raw materials, materials, accessories and other intermediate products.
7> Agricultural Chemicals: Research and agriculture related chemical, including pesticide, plant growth regulator, fertilizer, compound fertilizer, herbicide etc.
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