4-tert-Octylphenol CAS 140-66-9

p-T-octylphenol can induce the apoptosis of brain neural progenitor cells in spawn computer mice, and as an endocrine disruptor, this material can be used as an estrogen medicine. In the production of great chemicals, p-tert-octylphenol is extensively made use of in the manufacture of oil-soluble octylphenol-formaldehyde resins, surfactants, medications, pesticides, additives, adhesives, and also ink fixatives. In organic artificial chemistry, p-tertoctylphenol can undertake nucleophilic alternative reaction with alkyl iodides under alkaline conditions to obtain matching alkyl ether by-products.

In a dry response flask, p-tert-octylphenol (3.72 g, 17.5 mmol) was liquified in anhydrous pyridine (15 ml) under argon ambience. The mix was cooled down in an ice-water bathroom, as well as trifluoroacetic anhydride (6 mL, 35 mmol) was gradually added dropwise by means of syringe to the resulting response combination, and also the ice-water bath was gotten rid of. The blend was permitted to mix over night and also the resulting yellow solution was poured into a separatory channel including a 1:1 diethyl ether/water mixture (100 mL). After mixing, the yellow aqueous phase was separated and also the natural phase was cleaned with water (50 ml) and 5% v/v hydrochloric acid remedy (2 x 50 ml). All water washes were integrated and also the liquid service was drawn out with 50 mL diethyl ether, the natural layer was separated and also dried over Na2SO4. The liquid service was filteringed system and evaporated to dryness. The resulting deposit was dissolved in a 20% diethyl ether/n-hexane mixture, and also the resulting reaction blend was slowly filtered through a pad of silica gel and eluted with 200 mL of the same combined solvent. The resulting anemic filtrate was evaporated to dry skin to acquire the target item molecule.