4-Methyl-2-Pentanone CAS 108-10-1

Factory Supply 4-Methyl-2-Pentanone CAS 108-10-1 with Best Price

  • Appearance: Colorless liquid
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: 4-Methyl-2-Pentanone Supplier & Manufacturer

Basic Info of 4-Methyl-2-Pentanone

What is 4-Methyl-2-Pentanone?

4-methyl-2-pentanone (methyl isobutyl ketone) reagent is commonly used in chemical as well as pharmaceutical solvents, splitting up and also recuperation of nuclear fission products, and clinical research and test. The material of 4-methyl-2-pentanone sold on the marketplace is ≤ 99%, which includes a percentage of alcohol, acidic compounds, water as well as other pollutants.

4-methyl-2-pentanone is utilized as a solvent for nitrocellulose, paint and also some polymers as well as materials, and also as a reactant for the synthesis of 2 – (1-hydroxy-3-methylbutylene) – 1h-indene-1,3 (2H) – dione.

Methyl isobutyl ketone (MIBK) is a medium boiling point solvent and also chemical intermediate with excellent performance. It is generally utilized as state-of-the-art coating solvent in vehicle, aerospace, house decoration as well as various other areas, in addition to rubber anti-oxidant, lubricating substance dewaxing agent, organic synthetic extractant, diluent and also surfactant for aircraft and automobile tires. Methyl isobutyl ketone has a variety of application and also demand. Impacted by the development of terminal industry, the industry is currently in a stable growth phase.

4-Methyl-2-Pentanone Uses

  • Flavors. 4-Methyl-2-pentanone is mostly utilized to prepare rum, cheese and also fruit taste.
  • Solvent for nitrocellulose, material, periodontal, and so on. Extractants of certain inorganic salts. Organic synthesis.
  • 4-Methyl-2-pentanone is utilized as intermediate of medicine and also color. The chemical acaricin created by o-chlorobenzaldehyde can manage mites on dry crops as well as fruit trees. O-chlorobenzoxime can be obtained by oximation of o-chlorobenzaldehyde, as well as o-chlorobenzoxime can be acquired by further chlorination, both of which are pharmaceutical intermediates.
  • 4-Methyl-2-pentanone is a superb medium boiling solvent. It is utilized as mineral handling representative, solvent for oil dewaxing, coupler for shade movies, as well as solvent for tetracycline, pyrethroid and DDT, glue, rubber glue, mask paint for airplane and versions. It is also an efficient separating agent for some not natural salts. It can divide plutonium from uranium, niobium from tantalum, and zirconium from hafnium. Its peroxide is a really important initiator in the polymerization of polyester material. It is additionally made use of in the natural synthesis market. It can likewise be utilized as anticoagulant as well as diluent of plastic material.

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Application of 4-Methyl-2-Pentanone

CN201210221816.8 discloses a method for preparing 2-(4-oxyphenoxy) propionic acid, comprising the following steps: mixing 183 parts by weight of hydroquinone and 202.5 parts by weight of methyl S-2-chloropropionate Put it into the reaction kettle, add 100 parts by weight of sodium hydroxide in the first batch, heat the reaction kettle to 70-81 ° C and keep it for 8 hours, after the reaction is completed, lower the temperature of the reaction kettle to room temperature; then add 128 parts by weight of hydrochloric acid to the reaction kettle again , keep the pH value of about 5~6, in a weakly acidic environment, excess sodium hydroquinone reacts with hydrochloric acid to produce hydroquinone; add extractant 4-methyl-2-pentanone to the reactor, the solution Layering, the organic layer is hydroquinone and extractant, the water layer is intermediate A/B, methanol and salt solution; the organic phase mixture is separated, 4-methyl-2-pentanone is distilled under reduced pressure, and p-benzene is centrifuged. Diphenol crystals; 128 parts by weight of hydrochloric acid were added dropwise to the water phase after the dealcoholation, the pH value was adjusted to 1~2, the intermediate reacted under the acid precipitation condition, and 2-(4-oxyphenoxy group was precipitated after adding the acid) ) propionic acid. The invention has the advantages of simple operation, low cost and less pollution, and is suitable for large-scale industrial application.

CN201310265574.7 discloses a method for purifying tiamulin fumarate. The process steps are as follows: first, neutralize tiamulin base with methanol and fumaric acid to form a salt, and then centrifuge the obtained crude product into 4-methyl In -2-pentanone, keep the temperature at 40~60°C for 90~110min under stirring, then rapidly cool down to -20~-10°C, keep the temperature for 90~110min, and centrifuge again. The obtained fine product is put into a double cone rotary vacuum dryer, After drying until the moisture content of the material is less than or equal to 0.5%, it can be sieved and packaged. The invention simplifies the domestic conventional refined tiamulin fumarate production process, adopts MIBK (4-methyl-2-pentanone) to replace butyl acetate or acetone, reduces organic solvent consumption, improves safety factor, and reduces potential safety hazards; shortens production Cycle, improve crystallization quality and yield, reduce energy consumption, improve production efficiency, and have certain development prospects.

Preparation of 4-Methyl-2-Pentanone

A method for purifying high-purity organic solvent 4-methyl-2-pentanone, the steps are as follows:

  1. The raw material 4-methyl-2-pentanone (content is about 99%) is lifted to the top of the adsorption column, wherein the adsorption column is 1.2M in height, 3.0cm in diameter, and the amount of the acid alumina adsorbent inside is the column height 4/5, the raw material is adsorbed at a speed of 30mL/min; in the column, 4-methyl-2-pentanone is fully contacted with the adsorbent acidic alumina, so that a small amount of alcohol and acidic impurities are adsorbed, and the adsorption effluent is detected. The quality of the effluent to be adsorbed is qualified, that is, each index of the effluent is close to the technical index requirements of the chromatographic grade (see Table 1 for specific technical index requirements), enter the next step operation, and remove the pre-adsorption fraction with high impurities.
  2. The 4-methyl-2-pentanone flowing out of the above-mentioned adsorption column is entered into the drying column, the column height is 1.2M, the diameter is 3.0cm, and the anhydrous calcium sulfate dried by baking is loaded, and the 4-methyl sulfate after drying is measured. – The water content of 2-pentanone, the water content should be controlled at ≤0.05%, and the next step will be performed after the water content is qualified; if the water content is greater than 0.1%, it means that the desiccant has been saturated with water and must be replaced before drying.
  3. Above-mentioned 4-methyl-2-pentanone after drying is pushed into the glass rectifying still of 20L and carries out rectification, utilizes electric heating, controls about 200 ℃ of temperature at the bottom of the still, 4-methyl-2 – The liquid temperature of pentanone is about 120 °C, the liquid temperature is about 117 °C, and the reflux ratio is controlled to be 1:0.5 to 1:2. Bottled and sealed under nitrogen protection, a qualified chromatographic grade 4-methyl-2-pentanone product (purity ≥99.5%) is obtained, and the front fraction is further processed.


  1. Methyl isobutyl ketone – PubChem
  2. CN201010611454.4 A kind of purification method of high-purity organic solvent 4-methyl-2-pentanone

4-Methyl-2-Pentanone Supplier and Manufacturer

As a 4-methyl-2-pentanone supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best 4-methyl-2-pentanone raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for 4-methyl-2-pentanone and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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