4-Fluorobenzaldehyde CAS 459-57-4
Factory Supply 4-Fluorobenzaldehyde CAS 459-57-4 with Best Price
- Appearance: Colorless liquid
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: 4-Fluorobenzaldehyde Supplier & Manufacturer
4-Fluorobenzaldehyde: The Complete Guide
4-Fluorobenzaldehyde for Sale
|Other Name:||p-Fluorobenzaldehyde; 4-Fluoro-benzaldehyd; Benzaldehyde, p-fluoro-|
|Type:||Pesticide raw materials; Pesticide intermediates; Pharmaceutical raw materials; Organic raw materials|
What is 4-Fluorobenzaldehyde?
p-Fluorobenzaldehyde (4-fluorobenzaldehyde) is a very important class of fine chemicals, which have important uses in medicine, pesticides, new materials, polymers, etc. For example, haloperol, droperid, rosuvastatin calcium and other important drugs in medicine, among them, it is the key raw material used to manufacture rosuvastatin calcium core, and has very important value.
P-Fluorobenzaldehyde is an important intermediate in organic synthesis, which can be used in the synthesis of medicines, such as antihypertensive drugs, antipyretic, analgesic and anti-inflammatory drugs, anticancer drugs, muscle relaxants, etc. The earliest synthesis methods of p-fluorobenzaldehyde include the oxidation of p-fluorotoluene, the oxidation of p-fluorobenzyl alcohol or p-fluorophenylacetic acid, and the reduction of p-fluorobenzonitrile. Due to the instability of the intermediates used, the poisonous raw material hydrogen fluoride, and many synthetic steps, these methods have made little progress in industrial development and research, and seem to be unable to be used in large-scale industrial production.
In recent years, Japan, the United States, etc. have realized the importance of p-fluorobenzaldehyde, vigorously carried out the development and research of new synthetic methods, made major breakthroughs, and developed some economical and reasonable synthetic methods that can be used in large-scale production.
4-Fluorobenzaldehyde is a kind of fluorobenzaldehyde, which has inhibitory activity on mushroom tyrosinase.
4-Fluorobenzaldehyde is used to prepare pyrazopyridine derivatives and as mitogen-activated protein kinase (MAPK) inhibitor.
It is used in the preparation of weakly acidic bright yellow 2G and weakly acidic bright yellow 5G in dyes, and is also used in the preparation of rice JFF, plant growth regulators, etc.
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Preparation of 4-Fluorobenzaldehyde
- 110.5g of p-fluorotoluene is added to 500ml of difluorotoluene, and chlorine gas is continuously fed into the middle to carry out chlorination reaction, and the progress of the reaction is controlled by GC tracking method, so that the content of monochlorobenzyl product is less than 2%, and the content of trichlorobenzyl product is less than 2%. less than 10%.
- Add 6.9g of FeCl3+ZnCl2 catalyst to it, then heat up to 130°C, add 1.7ml of water to initiate the reaction for hydrolysis, and control the temperature to reflux at 130°C.
- Add water dropwise in the there-necked flask, make the complete hydrolysis of dichlorobenzyl product.
- After the reaction finishes, adjust the pH value to 8.0～9.0 with a concentration of 30% sodium hydroxide solution, then leave to stand for stratification.
- Adding 10% hydrochloric acid to adjust the pH value to 5.0-7.0, adding toluene to extract the organic layer.
- Finally, the solvent was spin-dried, the product was dried, and the organic layer was rectified to obtain p-fluorobenzaldehyde.
The yield of p-fluorobenzaldehyde was 80%.
- 4-Fluorobenzaldehyde – PubChem
- [Chinese invention] CN201910835870.3 A new method for preparing p-fluorobenzaldehyde by catalytic oxidation of hydrogen peroxide
4-Fluorobenzaldehyde Supplier and Manufacturer
As a 4-fluorobenzaldehyde supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best 4-fluorobenzaldehyde raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for 4-fluorobenzaldehyde and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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